Cell Adhesion to PEEK Treated by Plasma Immersion Ion Implantation and Deposition for Active Medical Implants

Awaja, Firas; Bax, Daniel V.; Zhang, Shengnan; James, Natalie L.; McKenzie, David R.

doi:10.1002/ppap.201100034

Cited by 62 publications

(54 citation statements)

References 24 publications

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“…Human bone morphogenetic protein, for example, covalently bound to titanium using anchor molecules, significantly increases osteoinduction . PIII treatment of PEEK can produce this bioactivity without the need for anchor molecules and at the same time prevent adverse stress shielding associated with the use of metallic implants that result from a mismatch of material moduli . Despite the advantages, this process has not been optimised and fully characterised for PEEK.…”

Section: Introductionmentioning

confidence: 99%

Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model

Wakelin

Kondyurin

Wise

et al. 2014

Plasma Process. Polym.

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Plasma immersion ion implantation (PIII) is used in this study to improve the surface bioactivity of polyether ether ketone (PEEK) by modifying the chemical structure and introducing radicals. The kinetic properties of the treated surface are characterised here, allowing for tuning of the PIII process in order to produce PEEK with optimised bioactivity. The optimum PIII ion fluence for PEEK is determined to be 1 × 1016 ions/cm2. A model is proposed that accounts for the decay of radicals, nitrogen loss, oxygen incorporation and changes in surface energy within the structure. The model is based on the premise that there is a distribution of local chemical environments produced by PIII. The distribution of chemical environments results in a bioactive surface that has a long shelf life, compatible with clinical needs.

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Section: Introductionmentioning

confidence: 99%

Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model

Wakelin

Kondyurin

Wise

et al. 2014

Plasma Process. Polym.

Self Cite

View full text Add to dashboard Cite

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“…It must be noted that PEEK is a hydrophobic material. As such, it does not actively bond to tissue, creating potential issues in regards to anatomical integration as bone cells will not bond to the implants [59]. Whilst there are a number of coatings which can alleviate these concerns [53,58], un-coated PEEK remains at a disadvantage in regards to achieving stable fixation in a short timeframe.…”

Section: Discussionmentioning

confidence: 99%

“…For cranioplasty applications, PEEK tends to be manufactured with a smooth surface. In addition, its hydrophobic properties are such that concerns exist in regards to the materials anatomical integration potential [53,58,59], as such, both the ISF and TAB ranking can be considered to be 0.…”

Section: Polyetheretherketone (Peek)mentioning

confidence: 99%

Cranioplasty and Craniofacial Reconstruction: A Review of Implant Material, Manufacturing Method and Infection Risk

et al. 2017

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Background: Analysis of current literature highlights a wide variation in reported infection risk for different materials in cranial repair. The purpose of these composite materials are to mimic natural bone and assist in restoring function (structurally and aesthetically) to the human skull. This review aims to examine the meta-data in order to provide an amalgamated overview of potential trends between implant material, manufacturing method and infection risk, in order to provide a core reference point for future studies surrounding emerging biomedical materials in the fields of cranioplasty by providing base point for understanding the capabilities and limitations of current technologies. Methods: A search for articles was conducted, with the following criteria seen as fundamental in providing an accurate picture of the current landscape: publication in the last decade, provision of a numerical value for both number of implants and infection cases, patient sample of 10+, adult patients, and cranioplasty/cranial repair. Results: A total of 41 articles were seen to meet the author's inclusion criteria. Average infection rates per material ranged between 2.04% and 10.98%. The results indicate that there is variation between materials in regards to total infection risk, however, depending on the materials compared, this value may be insignificant. Alternative risk factors associated with infection, including surgical time, revisions and previous infection, have a greater impact on infection potential than material variation. Comparison of fabrication methods did highlight a notable effect on average infection rate. Trends can be observed showing that materials with greater levels of surface interaction and active support of tissue ingrowth presented greater infection resistance. Such characteristics are due to the physical structures of the implants. Conclusions: It can be said that the manufacturing methods can influence biomedical materials to assist in minimizing implant infection risk.

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“…Spinal fusion cages are hollow cylindrical or square-shaped prosthetics that are placed in between two problematic vertebrae to allow bone growth, leading to fusion of the two 62 Osteoblast proliferation, alkaline phosphate activity, and mineralization activity using osteoblastlike cell line (MG-63) Nakahara et al 33,34 Implantation of CFRPPEK acetabular cup and femoral stem in sheep Awaja et al 37 Cell attachment analysis test using MG63 cells on PEEK samples Zhao et al 38 Cell adhesion test by seeding the mouse MC3T3-E1 preosteoblast on 3D porous network on PEEK surface Implantation of SPEEK-WA,SPEEK-W, And PEEK cylindrical samples in distal femur of rat…”

Section: Peek In Spine Implantsmentioning

confidence: 99%

Biomechanical and bioactivity concepts of polyetheretherketone composites for use in orthopedic implants—a review

Abdullah

Goharian

Kadir

et al. 2015

J Biomedical Materials Res

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The use of polyetheretherketone (PEEK) composites in the trauma plating system, total replacement implants, and tissue scaffolds has found great interest among researchers. In recent years (2008 afterward), this type of composites has been examined for suitability as substitute material over stainless steel, titanium alloys, ultra high molecular weight polyethylene, or even biodegradable materials in orthopedic implant applications. Biomechanical and bioactivity concepts were contemplated for the development of PEEK orthopedic implants and a few primary clinical studies reported the clinical outcomes of PEEK-based orthopedic implants. This study aims to review and discuss the recent concepts and contribute further concepts in terms of biomechanical and bioactivity challenges for the development of PEEK and PEEK composites in orthopedic implants.

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Cell Adhesion to PEEK Treated by Plasma Immersion Ion Implantation and Deposition for Active Medical Implants

Cited by 62 publications

References 24 publications

Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model

Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model

Cranioplasty and Craniofacial Reconstruction: A Review of Implant Material, Manufacturing Method and Infection Risk

Biomechanical and bioactivity concepts of polyetheretherketone composites for use in orthopedic implants—a review

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