Cell and cell-derivative-based therapy for liver diseases: current approaches and future promises

Zahmatkesh, Ensieh; Rad, Niloofar Khoshdel; Mohamadnejad, Mehdi; Gramignoli, Roberto; Najimi, Mustapha; Malekzadeh, Reza; Hassan, Moustapha; Vosough, Massoud

doi:10.1080/17474124.2023.2172398

Cited by 3 publications

(1 citation statement)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These challenges encourage scientists to develop novel therapeutic approaches to overcome these impediments. Cell therapy is a novel therapeutic approach based on transplantation of intact, living cells with the ability of differentiation and secretion of beneficial molecules [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

Arki,

Moeinabadi-Bidgoli,

Hossein-Khannazer

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis, detoxification, and numerous other necessary functions. Various acute, chronic, and neoplastic disorders affect the liver and hamper its biological functions. Most of the untreated liver diseases lead to inflammation and fibrosis which develop into cirrhosis. The human amniotic membrane (hAM), the innermost layer of the fetal placenta, is composed of multiple layers that include growth-factor rich basement membrane, epithelial and mesenchymal stromal cell layers. hAM possesses distinct beneficial anti-fibrotic, anti-inflammatory and pro-regenerative properties via the secretion of multiple potent trophic factors and/or direct differentiation into hepatic cells which place hAM-based therapies as potential therapeutic strategies for the treatment of chronic liver diseases. Decellularized hAM is also an ideal scaffold for liver tissue engineering as this biocompatible niche provides an excellent milieu for cell proliferation and hepatocytic differentiation. Therefore, the current review discusses the therapeutic potential of hAM and its derivatives in providing therapeutic solutions for liver pathologies including acute liver failure, metabolic disorders, liver fibrosis as well as its application in liver tissue engineering.

show abstract

Section: Introductionmentioning

confidence: 99%

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

Arki,

Moeinabadi-Bidgoli,

Hossein-Khannazer

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

Hepatocyte-like cells and liver organoids: the application of iPSCs and their derivants for treating liver diseases

Ju,

Tian,

Shang

et al. 2024

Mater. Adv.

View full text Add to dashboard Cite

show abstract

Development of Liver Cancer Organoids: Reproducing Tumor Microenvironment and Advancing Research for Liver Cancer Treatment

Li,

Ren,

et al. 2024

Technol Cancer Res Treat

View full text Add to dashboard Cite

Liver cancer a leading cause of cancer-related deaths worldwide, yet understanding of its development mechanism remains limited, and treatment barriers present substantial challenges. Owing to the heterogeneity of tumors, traditional 2D culture models are inadequate for capturing the complexity and diversity of tumor biology and understanding of the disease. Organoids have garnered considerable attention because of their ability to self-renew and develop functional structures in vitro that closely resemble those of human organs. This review explores the history of liver organoids, their cellular origins, techniques of constructing tumor microenvironments that recapitulate liver cancer organoids, and the biological and clinical applications of liver and liver cancer organoids and explores the current challenges related to liver cancer organoid applications and potentially valuable solutions, with the aim of facilitating the construction of in vitro clinical models of liver cancer therapeutic research.

show abstract

Cell and cell-derivative-based therapy for liver diseases: current approaches and future promises

Cited by 3 publications

References 155 publications

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

Amniotic Membrane and Its Derivatives: Novel Therapeutic Modalities in Liver Disorders

Hepatocyte-like cells and liver organoids: the application of iPSCs and their derivants for treating liver diseases

Development of Liver Cancer Organoids: Reproducing Tumor Microenvironment and Advancing Research for Liver Cancer Treatment

Contact Info

Product

Resources

About