Cell and Cell-Matrix Interactions in Breast Carcinoma: The Present State of Problems

Мнихович, М В

doi:10.17816/pavlovj20142152-161

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…However, according to modern studies, extracellular matrix of breast tissue is very sensitive to the changes in the structure of epithelial cells parenchyma that forms lobules and ducts. As the result of epithelial cells mutation and their growth inside stroma, the parenchymal-stromal relation also changes leading to alterations in the structure of collagen fibers and elastin [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Сергеева¹,

Kirillin²,

Dudenkova³

et al. 2019

Sovrem Tehnol Med

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The goal of the study is to develop the approach for the express analysis of ex vivo biopsy specimens of breast tissue based on twophoton microscopy (TPM). Materials and Methods. We studied breast tissue samples obtained by trephine biopsy procedure. TPM images of breast stroma obtained from the ex vivo biopsy specimens were compared with TPM images of the unstained deparaffinized 10-μm thick histological sections of breast tissue. The study included samples of patients with fibroadenoma (2 cases), in situ carcinoma (1 case), and invasive carcinoma of non-specific type I-II grade (4 cases). In the frames of numerical processing of TPM images, collagen disorganization factor maps based on spatial Fourier analysis were constructed. Results. We have demonstrated the feasibility of the TPM technique in detecting stroma remodeling in breast biopsy specimens in the development of benign and malignant changes. Typical images of biopsy specimens and histological sections were obtained for normal breast tissue, fibroadenoma and various types of carcinomas. Distinction between typical images of benign and malignant tumors was demonstrated. Changes in collagen fibers structure and the presence/absence of elastin fibers in the considered pathological cases were revealed. Differences in TPM images of biopsy specimens and histological sections are shown, which may originate from the distortion of fiber shape in the course of histological sample preparation. The proposed algorithm for quantitative TPM image processing allows objectifying the results of imaging, which is an essential step towards automated express diagnostics. Conclusion. Two-photon microscopy has high potential as the express biopsy technique for the primary diagnosis of breast tissue, as well as for intraoperative use.

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Section: Discussionmentioning

confidence: 99%

Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Сергеева¹,

Kirillin²,

Dudenkova³

et al. 2019

Sovrem Tehnol Med

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Clinical case of torpid course of metastatic triple negative breast cancer

Куликов¹,

Golovkin

Александрович

et al. 2022

Sib. onkol. ž.

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Background. Breast cancer is the most common cancer and the leading cause of cancer death in women worldwide. The presence of an unfavorable molecular biological subtype significantly worsens the prognosis, making it necessary to individualize treatment strategy for each patient.The aim of the study was to demonstrate the achievement of long-term remission in the treatment of metastatic triple-negative breast cancer. Case description. A 42-year-old patient presented to Ryazan Oncologic Dispensary in October 2006 with complaints of lump in her left breast. She was diagnosed with stage cT2N0M0 triple-negative carcinoma of the left breast. She underwent radical mastectomy for left breast cancer (October, 2006). Disease progression (metastases to lungs and mediastinal lymph nodes) occurred in June 2009. The patient received 6 courses of polychemotherapy according to the FAC regimen with a favorable response. In February 2011, the patient was found to have metastatic lesion in the brain, which was surgically removed in March, 2011. She received metronome chemotherapy. Recurrence of brain metastasis occurred 6 months after chemotherapy. The patient received external beam radiation therapy, which resulted in tumor regression, and metronomic chemotherapy was continued with a positive effect. The patient was followed up for 6 years with no evidence of disease progression. In July 2019, the follow-up examination revealed stage cT2N0M0 triple-negative cancer in the right breast. The patient underwent radical mastectomy for the right breast and 8 courses of adjuvant polychemotherapy (4 courses of AC + 4 courses of paclitaxel). The patient is alive with no signs of disease progression.Conclusion. This clinical case demonstrated personalized approach to the treatment of patients with triple-negative breast cancer. Fifteen years had passed since the detection of the primary tumor. During this time, the disease progressed three times, and breast cancer was diagnosed on the opposite side. Combined modality treatment including chemotherapy, surgery and radiotherapy allowed satisfactory results to be achieved. The patient is still alive with no signs of disease progression.

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Cell and Cell-Matrix Interactions in Breast Carcinoma: The Present State of Problems

Cited by 2 publications

References 23 publications

Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Clinical case of torpid course of metastatic triple negative breast cancer

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