Cell and Molecular Biology of Thyroid Disorders

Grimm, Daniela

doi:10.3390/ijms20122895

Cited by 14 publications

(17 citation statements)

References 35 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thyroid cancer (TC) is the most common endocrine malignancy [1,2]. According to National Cancer Institute surveillance, epidemiology, and end results (SEER), the yearly TC incidence has nearly tripled since 1975.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma

Póvoa

Teixeira

Bella

et al. 2020

Cancers

View full text Add to dashboard Cite

Papillary thyroid cancer (PTC) has an indolent nature and usually excellent prognosis. Some PTC clinicopathological features may contribute to the development of aggressive metastatic disease. In this work, we want to evaluate PTC clinicopathological features that are presurgical prognostic predictors of patients’ outcomes and find which indicators are more adequate for tailoring surgical procedures and follow-up. We studied a series of 241 PTC patients submitted to surgery. All patients’ files and histological tumor samples were reviewed. The 8th edition AJCC/UICC (American Joint Committee on Cancer/Union for International Cancer) Controlstaging system and the 2015 American Thyroid Association risk stratification system were used. Total thyroidectomy was performed in 228 patients, lymphadenectomy in 28 patients. Gross extrathyroidal extension (ETE) was present in 10 patients and 31 tumor resection margins were incomplete. Cervical lymph node metastases (LNMs) were present in 34 patients and distant metastases at diagnosis in four patients. In multivariate analysis, male gender (OR = 15.4, p = 0.015), venous invasion (OR = 16.7, p = 0.022), and lateral compartment LNM (OR = 26.7, p = 0.004) were predictors of mortality; psammoma bodies (PBs) (OR = 4.5, p = 0.008), lymph vessel invasion (OR = 6.9, p < 0.001), and gross ETE (OR = 16.1, p = 0.001) were predictors of structural disease status; male gender (OR = 2.9, p = 0.011), lymph vessel invasion (OR = 2.8, p = 0.006), and incomplete resection margins (OR = 4.6, p < 0.001) were predictors of recurrent/persistent disease. Our study supports that the factors helping to tailor patient’s surgery are male gender, presence of PBs, gross ETE, and lateral compartment LNM. Together with pathological factors, lymph vessel invasion, venous invasion, necrosis, and incomplete surgical resection, should be taken into consideration regarding treatment and follow-up of patients.

show abstract

Section: Introductionmentioning

confidence: 99%

“…PTC is the most common malignancy originating from the thyroid (80-90% of all TC types [1]). Treatment includes surgical resection of the thyroid gland with radioiodine (RAI) ablation in selected cases.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma

Póvoa

Teixeira

Bella

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…It may occur in genetically predisposed individuals who are exposed to certain exogenous factors, such as iodine, selenium, smoking, bacterial and viral infections, allergies, radiotherapy or emotional stress. Endogenous factors such as age, sex, pregnancy, hormones and birth weight are also important [1,2,3,4]. GD develops due to a loss of immunological tolerance and reactivity to thyroid autoantigens, mainly directed against the thyrotropin receptor.…”

Section: Introductionmentioning

confidence: 99%

“…GD develops due to a loss of immunological tolerance and reactivity to thyroid autoantigens, mainly directed against the thyrotropin receptor. This leads to the infiltration of this gland by T lymphocytes and B lymphocytes that produce antibodies specific for this disease entity, with a clinical manifestation of hyperthyroidism in the form of GD [1,2,3,4]. Recent studies have confirmed the importance of toll-like receptors (TLRs) and proinflammatory cytokines in the etiopathogenesis of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…They participate in the induction and effector phase of the immune and inflammatory response, thus playing a key role in the pathogenesis of the disease. Within inflammatory cells and the thyroid, follicular cells increasing expression of many cytokines has been detected, including interleukin (IL)-1 alpha, IL-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-14, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) [1,3,4,5]. Studies have shown that gene polymorphisms for cytokines or their abnormal secretion may not only increase the risk of developing GD but may also affect the course of the disease and prognosis [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toll-Like Receptors-2 and -4 in Graves’ Disease—Key Players or Bystanders?

Polak

Grywalska

Klatka

et al. 2019

IJMS

View full text Add to dashboard Cite

Graves’ disease (GD) is an autoimmune disease that affects the thyroid. The development of autoimmunity is associated with innate immune responses where the prominent role plays Toll-like receptors (TLRs). The aim of our study was to assess the relationship between the expression levels of TLR-2 and TLR-4 on CD4+ and CD8+ T as well as CD19+ B lymphocytes in patients with GD and selected clinical parameters. The study group consisted of 32 women with GD, the control group consisted of 20 healthy women. Immunophenotyping was performed using the flow cytometry and cytokines concentrations were assessed using ELISA assay. The mean percentage of CD4+/TLR-2+ and CD8+/TLR-2+ T cells in patients with GD was higher than in the control group (p < 0.0001). After obtaining euthyroidism, the mean percentage of CD4+/TLR-2+ T cells in patients with GD decreased (p < 0.0001). The expression level of TLR-2 on CD4+ T lymphocytes correlated with serum FT3 concentration in patients with GD (r = 0.47, p = 0.007). The mean percentage of CD8+/TLR-2+ T cells in patients with GD before treatment compared to patients with GD after obtaining euthyroidism was higher (p = 0.0163). Similar findings were found for TLR-4. Thus the TLR-2 and TLR-4 can be a prognostic marker for Graves’ disease.

show abstract

Analysis of factors associated with the prognosis of papillary thyroid cancer and the construction of a survival model

et al. 2022

View full text Add to dashboard Cite

Objective: To study the survival prediction value of lymph node ratio (LNR) and preoperative thyroglobulin (Tg) in the prognosis of thyroid papillary carcinoma (PTC).Methods: A total of 495 patients with PTC and lymph node metastasis treated at the Cancer Hospital of Xinjiang Medical University were selected for a retrospective study. The disease-free survival (DFS) of patients was the follow-up endpoint. DFS was calculated for all patients. The Cox proportional risk regression model and nomogram were used to predict the survival prognosis of PTC with lymph node metastasis by index. LNR and preoperative Tg level cutoff values were obtained using ROC curves. To express DFS, Kaplan-Meier survival curves were created. Using 3-and 5-year calibration curves and AUC values, the prognostic models' precision and discrimination were assessed. Clinical decision curve analysis was used to forecast clinical benefitability. Finally, the results were validated using internal cross-validation. Results:The cutoff values of LNR and preoperative Tg level were 0.295 and 50.24, respectively, and they were divided into two groups according to the cutoff values. Multifactorial Cox regression models showed that NLNM, LNR, and preoperative Tg level (all p < 0.05) were independent risk factors affecting the prognosis of PTC with lymph node metastasis. Kaplan-Meier curves showed higher DFS rates in the group with low NLNM (<10), LNR (<0.295), and preoperative Tg level (<50.24) groups. The 3-year and 5-year calibration curves showed good agreement. A ROC curve analysis was performed on the nomogram model, and its AUC values at 3 and 5 years were, respectively, 0.805 and 0.793. Clinical decision curves indicate good clinical benefit. Finally, internal cross-validation demonstrated the legitimacy of the prognostic model. Conclusion:The LNR and preoperative Tg levels, in combination with other independent factors, were effective in predicting the survival prognosis for patients with PTC.

show abstract

Cell and Molecular Biology of Thyroid Disorders

Abstract: The thyroid is a hormone gland involved in metabolism, regulatory functions, growth, and development of the human organism [...]

Cited by 14 publications

References 35 publications

Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma

Clinicopathological Features as Prognostic Predictors of Poor Outcome in Papillary Thyroid Carcinoma

Toll-Like Receptors-2 and -4 in Graves’ Disease—Key Players or Bystanders?

Analysis of factors associated with the prognosis of papillary thyroid cancer and the construction of a survival model

Contact Info

Product

Resources

About