Cell and molecular level of strategy of COVID-19 to induce immunodeficiency. Possible therapeutic solutions

Abstract

The review considers the nature of clinical and pathological disorders caused by highly pathogenic coronaviruses in the human body, analyzes the causes of systemic damage to various organs and tissues, the strategy of virus reproduction and the associated syndrome of cytokine reactivity with the development of specific immunodeficiency at the molecular level. The most developed approaches to the targeted therapy of cytokine reactivity syndrome and SARS including elements of theranostics — monitoring of molecular targets for targeted therapy — are described. An example of an innovative bioengineering technology associated with the reprogramming of cells of the primary "echelon of defense" with the ability to endow them with highly specific skills of directed destruction of cells infected with a virus is given.