Cell- and tissue-engineered organ replacements

Birchall, Martin A.

doi:10.1002/bjs.6666

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…One of the goals of regenerative medicine is the successful creation of "spare parts for surgery": the Holy Grail for tissue engineers. Although almost any surgeon would Wnd uses for extra cartilage, bone or muscle; it is perhaps in laryngology and head and neck surgery, where transplant and augmentation would have the most impact; in fact this already starting to become a reality [25]. One of the diYculties in tissue engineering is the creation of suitable nano-scale extracellular matrices (ECMs).…”

Section: Laryngology/head and Neckmentioning

confidence: 99%

Nanomedicine in otorhinolaryngology: what does the future hold?

Philpott

Gane

McKiernan

2010

Eur Arch Otorhinolaryngol

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Nanotechnology and nanomedicine are new and rapidly developing areas which are concerned with the utilisation of structures and devices, one billionth of a metre in scale and how their special properties may be utilised in the diagnosis and treatment of diseases. In otorhinolaryngology, there have been some inroads into utilising these new treatment modalities and there is future prospect for significant developments. Their impact may be to revolutionise the current practice of otorhinolaryngology. This review considers current developments and future prospects for nanotechnology in our specialty and considers the pitfalls that may be encountered. The online medical reference databases PubMed, Google Scholar, ISI Web of Science and Science Direct were searched with search terms "Nanotechnology, Nanomedicine" in combination with "Otolaryngology, ENT, Rhinology, Otology, Head and Neck Surgery, Laryngology" in turn. A number of developments are already showing promise in animal models, particularly for nanoparticle delivery of drugs, which may avoid some of the inherent systemic side effects seen with conventional application. Other possibilities include nanoscale reconstruction and regeneration of tissues and even unexpected spin-off technologies such as haemostatic agents. The future treatment of otorhinolaryngological diseases could be revolutionised by advances in nanomedicine and nanotechnology and diseases, such as olfactory disorders may become radically more amenable to medical treatment.

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Section: Laryngology/head and Neckmentioning

confidence: 99%

Nanomedicine in otorhinolaryngology: what does the future hold?

Philpott

Gane

McKiernan

2010

Eur Arch Otorhinolaryngol

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“…Tissue engineering of organs allows reconstruction or replacement of diseased or dysfunctional organs and documentations for allograft transplantation, dates back to 600BC indicating the use of tissues as flaps. Donor organ transplantation, which is a current option, is known to be limited due to short supply whilst transplantation of available donor organs are not without issues of life‐long immune suppression and other associated side effects 1–3. An increasingly ageing population, incident of cancer, accidents, military activities, as well as an interest in extreme sports predisposes a great number of individuals to organ dysfunction, loss of tissue or organs.…”

Section: Introductionmentioning

confidence: 99%

Orchestrating Cell/Material Interactions For Tissue Engineering of Surgical Implants

Mel

Seifalian

Birchall

2012

Macromolecular Bioscience

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Research groups are currently recognising a critical clinical need for innovative approaches to organ failure and agenesis. Allografting, autologous reconstruction and prosthetics are hampered with severe limitations. Pertinently, readily available 'laboratory-grown' organs and implants are becoming a reality. Tissue engineering constructs vary in their design complexity depending on the specific structural and functional demands. Expeditious methods on integrating autologous stem cells onto nanoarchitectured 3D nanocomposites, are being transferred from lab to patients with a number of successful first-in-man experiences. Despite the need for a complete understanding of cell/material interactions tissue engineering is offering a plethora of exciting possibilities in regenerative medicine.

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A potential platform for developing 3D tubular scaffolds for paediatric organ development

Mel

Yap

Cittadella

et al. 2015

J Mater Sci: Mater Med

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Children suffer from damaged or loss of hollow organs i.e. trachea, oesophagus or arteries from birth defects or diseases. Generally these organs possess an outer matrix consisting of collagen, elastin, and cells such as smooth muscle cells (SMC) and a luminal layer consisting of endothelial or epithelial cells, whilst presenting a barrier to luminal content. Tissue engineering research enables the construction of such organs and this study explores this possibility with a bioabsorbable nanocomposite biomaterial, polyhedral oligomeric silsesquioxane poly(ε-caprolactone) urea urethane (POSS-PCL).Our established methods of tubular graft extrusion were modified using a porogen-incorporated POSS-PCL and a new lamination method was explored. Porogen (40, 60 or 105 µm) were introduced to POSS-PCL, which were fabricated into a bilayered, dual topography matching the exterior and luminal interior of tubular organs. POSS-PCL with different amounts of porogen were tested for their suitability as a SMC layer by measuring optimal interactions with human adipose derived stem cells. Angiogenesis potential was tested with the chorioallantoic membrane assay. Tensile strength and burst pressures of bilayared tubular grafts were determined. Scaffolds made with 40 µm porogen demonstrated optimal adipose derived stem cell integration and the scaffolds were able to accommodate angiogenesis. Mechanical properties of the grafts confirmed their potential to match the relevant physiological and biophysical parameters. This study presents a platform for the development of hollow organs for transplantation based on POSS-PCL. These bilayered-tubular structures can be tailor-made for cellular integration and match physico-mechanical properties of physiological systems of interest. More specific luminal cell integration and sources of SMC for the external layer could be further explored.

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Cell- and tissue-engineered organ replacements

Abstract: Results are encouraging

Cited by 5 publications

References 8 publications

Nanomedicine in otorhinolaryngology: what does the future hold?

Nanomedicine in otorhinolaryngology: what does the future hold?

Orchestrating Cell/Material Interactions For Tissue Engineering of Surgical Implants

A potential platform for developing 3D tubular scaffolds for paediatric organ development

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