Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia

O’Reilly, Megan; Thébaud, Bernard

doi:10.1016/j.clp.2012.06.009

Cited by 23 publications

(17 citation statements)

References 114 publications

(99 reference statements)

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“…A number of putative resident progenitor cells have been identified in the lung, including proximal airway, distal lung epithelial, lung mesenchymal, and lung endothelial progenitor cells. Numerous experimental and clinical studies have tested the efficacy of these cell-based therapies in promoting lung regeneration after injury (comprehensively reviewed in [78]). Further, in a landmark report, Petersen et al successfully engineered rat lungs ex vivo using a decellularized lung extracellular matrix entirely repopulated with neonatal rat epithelial and endothelial cells, that functioned for a short time when implanted in rats in vivo [79].…”

Section: Overview Of Lung Developmentmentioning

confidence: 99%

Disrupted lung development and bronchopulmonary dysplasia

Baker¹,

Alvira

2014

Current Opinion in Pediatrics

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Purpose of review Advances of medical therapy have increased survival of extremely premature infants, and changed the pathology of bronchopulmonary dysplasia (BPD) from one of acute lung injury to a disease of disrupted lung development. With this evolution, new questions emerge regarding: (i) the molecular mechanisms that control postnatal lung development; (ii) the effect of early disruptions of postnatal lung development on long-term lung function; and (iii) the existence of endogenous mechanisms that permit lung regeneration after injury. Recent Findings Recent data demonstrate that a significant component of alveolarization, the final stage of lung development, occurs postnatally. Further, clinical and experimental studies demonstrate that premature birth disrupts alveolarization, decreasing the gas exchange surface area of the lung and causing BPD. BPD is associated with significant short-term morbidity, and new longitudinal, clinical data demonstrate that survivors of BPD have long-standing deficits in lung function, and may be at risk for the development of additional lung disease as adults. Unfortunately, current care is mainly supportive with few effective therapies that prevent or treat established BPD. These studies underscore the need to further elucidate the mechanisms that direct postnatal lung growth, and develop innovative strategies to stimulate lung regeneration. Summary Despite significant improvements in the care and survival of extremely premature infants, BPD remains a major clinical problem. While efforts should remain focused on the prevention of preterm labor and BPD, novel research aimed at promoting postnatal alveolarization offers a unique opportunity to develop effective strategies to treat established BPD.

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Section: Overview Of Lung Developmentmentioning

confidence: 99%

Disrupted lung development and bronchopulmonary dysplasia

Baker¹,

Alvira

2014

Current Opinion in Pediatrics

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“…Recent animal and human studies suggest that damage or depletion of epithelial and/or vascular stem cells in the developing lung likely contributes to the pathogenesis of BPD (75). For instance, hyperoxia-induced BPD in neonatal rats is associated with decreased circulating and resident mesenchymal stem cells (MSC) (76).…”

Section: Experimental Therapiesmentioning

confidence: 99%

Pulmonary hypertension in bronchopulmonary dysplasia

Berkelhamer

Mestan

Steinhorn

2013

Seminars in Perinatology

151

116

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Pulmonary hypertension (PH) is a common complication of neonatal respiratory diseases including bronchopulmonary dysplasia (BPD), and recent studies have increased awareness that PH worsens the clinical course, morbidity and mortality of BPD. Recent evidence indicates that up to 18% of all extremely low birth weight infants will develop some degree of PH during their hospitalization, and the incidence rises to 25–40% of infants with established BPD. Risk factors are not yet well understood, but new evidence shows that fetal growth restriction is a significant predictor of PH. Echocardiography remains the primary method for evaluation for BPD-associated PH, and the development of standardized screening timelines and techniques for identification of infants with BPD-associated PH remains an important ongoing topic of investigation. The use of pulmonary vasodilator medications such as nitric oxide, sildenafil, and others in the BPD population is steadily growing, but additional studies are needed regarding their long-term safety and efficacy.

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“…Bone marrow derived stem cells, mesenchymal stem cells or marrow stromal cells (MSCs) have demonstrated great promise in regenerative medicine for multiple organs including the lungs1. Although MSCs therapy showed beneficial effects in the treatment of injured tissue, their mechanisms of action are still being investigated.…”

mentioning

confidence: 99%

Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury

Perez

Ybarra

Chagnon

et al. 2017

Sci Rep

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Mesenchymal stem cells (MSCs) have potential for reducing inflammation and promoting organ repair. However, limitations in available techniques to track them and assess this potential for lung repair have hindered their applicability. In this work, we proposed, implemented and evaluated the use of fluorescence endomicroscopy as a novel imaging tool to track MSCs in vivo. MSCs were fluorescently labeled and injected into a rat model of radiation-induced lung injury via endotracheal (ET) or intravascular (IV) administration. Our results show that MSCs were visible in the lungs with fluorescence endomicroscopy. Moreover, we developed an automatic cell counting algorithm to quantify the number of detected cells in each condition. We observed a significantly higher number of detected cells in ET injection compared to IV and a slight increase in the mean number of detected cells in irradiated lungs compared to control, although the latter did not reach statistical significance. Fluorescence endomicroscopy imaging is a powerful new minimally invasive and translatable tool that can be used to track and quantify MSCs in the lungs and help assess their potential in organ repair.

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Cell-Based Strategies to Reconstitute Lung Function in Infants with Severe Bronchopulmonary Dysplasia

Cited by 23 publications

References 114 publications

Disrupted lung development and bronchopulmonary dysplasia

Disrupted lung development and bronchopulmonary dysplasia

Pulmonary hypertension in bronchopulmonary dysplasia

Tracking of Mesenchymal Stem Cells with Fluorescence Endomicroscopy Imaging in Radiotherapy-Induced Lung Injury

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