2016
DOI: 10.1002/jor.23268
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Cell‐based therapies for intervertebral disc and cartilage regeneration— Current concepts, parallels, and perspectives

Abstract: Lower back pain from degenerative disc disease represents a global health burden, and presents a prominent opportunity for regenerative therapeutics. While current regenerative therapies such as autologous disc chondrocyte transplantation (ADCT), allogeneic juvenile chondrocyte implantation (NuQu 1 ), and immunoselected allogeneic adipose derived precursor cells (Mesoblast) show exciting clinical potential, limitations remain. The heterogeneity of preclinical approaches and the paucity of clinical guidance h… Show more

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Cited by 46 publications
(50 citation statements)
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“…During the past decades, various kinds of cell sources were adopted in constructing cell-based scaffolds to regenerate degenerative discs, such as autologous or xenogenous NP cells and mesenchymal stem cells (MSCs) [42, 43]. Apart from the cell source, superior biocompatibility is another necessary requirement for cell-based scaffolds to regenerate degenerative discs.…”
Section: Discussionmentioning
confidence: 99%
“…During the past decades, various kinds of cell sources were adopted in constructing cell-based scaffolds to regenerate degenerative discs, such as autologous or xenogenous NP cells and mesenchymal stem cells (MSCs) [42, 43]. Apart from the cell source, superior biocompatibility is another necessary requirement for cell-based scaffolds to regenerate degenerative discs.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the isolation of tissue from adjacent healthy disc levels may increase the risk of initiating degeneration at the harvest site . This has motivated many researchers into identifying and characterizing alternative cell sources for disc regeneration, which is a key step towards translating therapies into clinical practice . Primary, differentiated cells from other skeletal sites with reduced risk for donor site morbidity, such as articular and nasal cartilage, have been investigated in vitro and in animal models for NP regeneration .…”
Section: Optimizing Cell Sources and Delivery Techniquesmentioning
confidence: 99%
“…Although the etiology is heterogeneous and some of the cases have no clear etiology, intervertebral disc (IVD) degeneration explains about 40% of low back pain [Vedicherla and Buckley, 2017]. There are 2 distinct cell populations in IVD: nucleus pulposus (NP) cells in the central part with chondrocyte-like properties, and annulus fibrous cells in the outer layer with a fibrocyte-like phenotype.…”
mentioning
confidence: 99%