Cell‐Based Therapy for Silicosis

Lopes‐Pacheco, Miquéias; Bandeira, Elga; Morales, Marcelo M.

doi:10.1155/2016/5091838

Cited by 84 publications

(71 citation statements)

References 100 publications

(104 reference statements)

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“…The mechanism that orchestrates silica‐induced lung damage involves direct cellular toxicity, an imbalance in oxidative stress enzymes, and the release of inflammatory and fibrotic cytokines 8–10 . The inflammatory response has been described as essential to the pathogenesis of silicosis, both in human studies and in experimental animal models.…”

Section: Introductionmentioning

confidence: 99%

“…7 The mechanism that orchestrates silica-induced lung damage involves direct cellular toxicity, an imbalance in oxidative stress enzymes, and the release of inflammatory and fibrotic cytokines. [8][9][10] The inflammatory response has been described as essential to the pathogenesis of silicosis, both in human studies and in experimental animal models. The activation and recruitment of macrophages and neutrophils into the lung parenchyma, particularly on the NALP-3 inflammasome, drives the production of inflammatory cytokines and chemokines, thus promoting and intensifying local tissue damage that culminates in collagen and elastin deposition and lung remodeling.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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Background Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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“…90 Cell-based therapy including bone marrow-derived mononuclear cell 91 and mesenchymal cell transplantation 92 have both demonstrated some benefit in animal models and are currently undergoing trials in humans. 93…”

Section: Antifibrotic Therapymentioning

confidence: 99%

Silica‐associated lung disease: An old‐world exposure in modern industries

et al. 2019

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Despite silica dust exposure being one of the earliest recognized causes of lung disease, Australia, USA, Israel, Turkey and other countries around the world have recently experienced significant outbreaks of silicosis. These outbreaks have occurred in modern industries such as denim jean production, domestic benchtop fabrication and jewellery polishing, where silica has been introduced without recognition and control of the hazard. Much of our understanding of silica‐related lung disease is derived from traditional occupations such as mining, whereby workers may develop slowly progressive chronic silicosis. However, workers in modern industries are developing acute and accelerated silicosis over a short period of time, due to high‐intensity silica concentrations, oxidative stress from freshly fractured silica and a rapid pro‐inflammatory and pro‐fibrotic response. Appropriate methods of screening and diagnosis remain unclear in these workers, and a significant proportion may go on to develop respiratory failure and death. There are no current effective treatments for silicosis. For those with near fatal respiratory failure, lung transplantation remains the only option. Strategies to reduce high‐intensity silica dust exposure, enforced screening programmes and the identification of new treatments are urgently required.

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“…To date, there is no efective treatment to halt or reverse the disease progression caused by silica-induced lung injury [19]. Efective therapies have to be found in order to reduce morbidity and mortality related to silicosis.…”

Section: Silicosis and Qi Deiciencymentioning

confidence: 99%

Introductory Chapter: Therapies Based on Kidney Essence and Qi in Chinese Medicine

Li¹

2017

Chinese Medical Therapies for Diabetes, Infertility, Silicosis and the Theoretical Basis

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Cell‐Based Therapy for Silicosis

Cited by 84 publications

References 100 publications

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Silica‐associated lung disease: An old‐world exposure in modern industries

Introductory Chapter: Therapies Based on Kidney Essence and Qi in Chinese Medicine

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