Cell behaviour in tubes

Riehle, Mathis; Ferris, Diana; Hamilton, David A.; Curtis, Adam

doi:10.1007/978-3-642-60083-8_2

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One unusual structure, unusual in terms of studies, but realistic in terms of biological equivalents, have been tunnels, which are difficult to fabricate and difficult to observe. Riehle et al (1998) have published on this important area.…”

Section: Topographic Signalsmentioning

confidence: 99%

Tissue engineering: the biophysical background

2001

View full text Add to dashboard Cite

Tissue engineering is the construction, repair or replacement of damaged or missing tissue in humans and other animals. This engineering may take place within the animal body or as tissue constructs to be made in a bioreactor for later grafting into the animal. The minimal set of materials for this are the appropriate types of cell. Usually, however, non-living substrata are used as well. These substrata may be nothing more than materials that bulk up any voids in the damaged tissue and provide the mechanical strength that has been lost when the tissue is damaged or removed. They may serve a similar pair of functions in the bioreactor. They can do much more in terms of pattern formation. The orientations and morphology of the cells, the arrangement of intercellular material as it is laid down and the relationships between different cell types in the repairing or construct tissue are all of importance, for these should resemble the correct normal tissue as closely as possible. Most of these requirements are ones involving pattern formation. This review discusses the various ways in which tissue pattern can be engineered chiefly from a biophysical standpoint. Unpatterned cells are effectively not tissue. This engineering includes the use of topography on the substrata, chemical patterning of adhesive and other cues for the cells, mechanical force application to cause cell orientation and appropriate synthetic responses and electrical fields. The review also discusses the methods used to impart the appropriate cues to and through the materials which are often biodegradable polymers. The article gives particular attention to regions of research and practice where the involvement of the physicist or biophysicist is of importance.

show abstract

Section: Topographic Signalsmentioning

confidence: 99%

Tissue engineering: the biophysical background

2001

View full text Add to dashboard Cite

show abstract

Tissue engineering: TGF-[beta] superfamily members and delivery systems in bone regeneration

Ramoshebi

Matsaba

Teare

et al. 2002

ERM

View full text Add to dashboard Cite

The induction of bone formation requires three parameters that interact in a highly regulated process: soluble osteoinductive signals, capable responding cells, and a supporting matrix substratum or insoluble signal. The use of recombinant and naturally derived bone morphogenetic proteins and transforming growth factor βs (TGF-βs) has increased our understanding of the functions of these morphogens during the induction of endochondral bone formation. In addition, growing understanding of the cellular interactions of living tissues with synthetic biomaterials has led to the in vivo induction of bone formation using porous biomimetic matrices as an alternative to the use of autografts for bone regeneration. This review outlines the basis of bone tissue engineering by members of the TGF-β superfamily, focusing on their delivery systems and the intrinsic induction of bone formation by specific biomimetic matrices with a defined geometry.

show abstract

Cell behaviour in tubes

Cited by 2 publications

References 13 publications

Tissue engineering: the biophysical background

Tissue engineering: the biophysical background

Tissue engineering: TGF-[beta] superfamily members and delivery systems in bone regeneration

Contact Info

Product

Resources

About