Cell Biology of the Endometrium

Leavitt, Wendell W.

doi:10.1007/978-1-4684-5589-2_7

Cited by 10 publications

(6 citation statements)

References 240 publications

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“…This secretion or "uterine milk" contains 20 to 30 different proteins as well as a number of polypeptide regulatory factors, including epidermal growth factor, platelet-derived growth factor, basic fibroblast growth factor, and interleukins (Leavitt et al 1989). GRP could be added to the list of uterine polypeptides because of the following: (1) GRP is synthesized and stored in the endometrial gland cells (Giraud et al 1993;Whitley et al 1998Whitley et al , 2000; (2) it is considered to be secreted into the gland lumen (Giraud et al 1993;Budipitojo et al 2001); (3) GRP has a proliferative effect on the endometrium (Endo et al 1991).…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural localization of gastrin-releasing peptide (GRP) in the uterine gland of cow

Budipitojo

Sasaki

Cruzana

et al. 2004

Anatomy and Embryology

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Gastrin-releasing peptide (GRP) is thought to act mainly as a neurotransmitter and localized almost exclusively to neurons and neuroendocrine cells. Recently, the localization of GRP in mammalian uterus and placenta has been demonstrated. Moreover, the exocrine manner of GRP release was deduced in ewes from the distribution of GRP on the uterine gland cells and its secretion as well as in the circulation. However, these reports have been examined at light-microscopic level. The present study was designed to make clear the localization of GRP in the uterine gland cells of nonpregnant and pregnant cows using an avidin-biotin-peroxidase complex (ABC) method at light-microscopic level and a pre-embedding immunogold with silver enhancement method at electron-microscopic level. The light-microscopic observation showed positive staining for GRP immunoreactivity in the supranuclear region and in the secreted materials of the uterine gland cells. At the electron-microscopic level, the supranuclear secretory granules and the secreted materials on the surface of the cell were labeled with immunogold particles representing GRP immunoreactivity in the uterine gland cells of nonpregnant and pregnant cows. Western blotting analysis showed a larger molecular form of GRP in the endometrial tissues taken from nonpregnant and pregnant cows. The present results revealed the localization of GRP in the uterine gland cells at light- and electron-microscopic levels and suggested the release of GRP from the cell into the lumen of the gland by exocrine manner.

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Section: Discussionmentioning

confidence: 99%

Ultrastructural localization of gastrin-releasing peptide (GRP) in the uterine gland of cow

Budipitojo

Sasaki

Cruzana

et al. 2004

Anatomy and Embryology

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“…Implantation is the critical phase in the ontogeny of eutherian mammals involving regulated and co-ordinated changes in the ovary, uterus with its internal milieu and blastocyst in a sequential order by synergistic action of ovarian estrogen and progesterone [15][16][17] . The results obtained in the present study suggest that treatment with 36 mg mancozeb for 8 days of pregnancy seems to be an effective dose as none of the mated mice were pregnant.…”

Section: Discussionmentioning

confidence: 99%

Anti-implantation Effect of a Carbamate Fungicide Mancozeb in Albino Mice.

Bindali¹,

Kaliwal²

2002

INDUSTRIAL HEALTH

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Mancozeb, an organocarbamate fungicide, was administered to examine the effect on implantation at doses of 18, 24, 30 and 36 mg/kg body weight/d to normal virgin swiss albino mice for 8 days to pregnant mice. The vaginal smear and body weight of the mice were recorded daily and mice were sacrificed on 9th day of pregnancy. There was a complete inhibition of implantation in 36 mg mancozeb treated mice with 100% pre-implantation loss. There was a partial inhibition of implantation in 24 and 30 mg mancozeb treated mice with 53.44 and 90.16% pre-implantation loss respectively. However, implantation was not affected in 18 mg mancozeb treated mice with 4.92% pre-implantation loss when compared to oil treated controls. To study the temporal effect, the effective dose of 36 mg/kg body weight/d mancozeb was administered orally for 3 and 5 days and on day 3 only. There was a complete inhibition of implantation in 5 days treated mice with 100% pre-implantation loss and partial inhibition of implantation of 3 days treated mice with 75% pre-implantation loss. However, implantation was not affected in mice treated on day 3 only with 1.63% pre-implantation loss when compared to control mice. There was a significant decrease in the diestrus phase with the result there was a concomitant increase in the estrus phase and there was a significant decrease in the uterus weight with 24, 30 and 36 mg and for 3 and 5 days with 36 mg mancozeb treatment. Inhibition of implantation by mancozeb may be due to hormonal imbalance or its toxic effects.

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“…This is transported to the oviduct by the circulatory system and readily passes through the plasmalemma of cells in the endometrial glands. Once inside the cell, estrogen is bound by a nuclear receptor protein, which binds to chromatin, stimulating transcription (O'Malley et al, 1979;Chambon et al, 1984;Gorski et al, 1987;Leavitt, 1989). Estrogen stimulates the gland cells of immature chicks to differentiate (Brant and Nalbandov, 1956) and to synthesize ovalbumin, ovotransferrin, ovomucoid, and lysozyme (Palmiter and Gutman, 1972; Palmiter and Schimke, 1973).…”

Section: Anterior Infundibulummentioning

confidence: 99%

Functional morphology and biochemistry of reptilian oviducts and eggs : implications for the evolution of reproductive modes in tetrapod vertebrates /

Palmer¹

1990

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Cell Biology of the Endometrium

Cited by 10 publications

References 240 publications

Ultrastructural localization of gastrin-releasing peptide (GRP) in the uterine gland of cow

Ultrastructural localization of gastrin-releasing peptide (GRP) in the uterine gland of cow

Anti-implantation Effect of a Carbamate Fungicide Mancozeb in Albino Mice.

Functional morphology and biochemistry of reptilian oviducts and eggs : implications for the evolution of reproductive modes in tetrapod vertebrates /

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