Cell biology of tissue factor, the principal initiator of blood coagulation

Camerer, Eric; Kolstø, Anne‐Brit; Prydz, Hans

doi:10.1016/0049-3848(95)00209-x

Cited by 401 publications

(315 citation statements)

References 240 publications

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“…It has been suggested that CRP can activate the complement system as well as bind to phagocytic cells and thus directly interact with the humoral and cellular effector systems of inflammation 24 . CRP can also enhance the expression of TF 21 . The recent report that CRP is increased in healthy individuals with risk of cardiovascular disease has emphasised the usefulness of CRP as an indicator of subclinical inflammatory response 25 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…TF is a primary activator of both the intrinsic and the extrinsic coagulation pathway 21 . A variety of agents known to induce or sustain inflammation, like TNF-a, IL-1 and CRP, are potent stimulators of TF expression 21 . The plasma level and the monocyte expression of TF are increased in overt pre-eclampsia demonstrating that enhanced expression of TF is a part of the inflammatory response in this disease as well 6,22 .…”

Section: Discussionmentioning

confidence: 99%

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Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia

Djurovic¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To compare indicators of systemic inflammatory response in the second trimester in women who developed pre-eclampsia with normal pregnancies. Design Prospective nested case control study derived from a cohort of 2190 pregnant women. Blood samples were obtained at 18 weeks of gestation. The following inflammatory parameters were measured: tumour necrosis factor-a (TNF-a), plasminogen activator inhibitor-1 (PAI-1), interleukin-1h (IL-1h), IL-6, IL-10, microCRP and tissue factor (TF). Setting Institute of Medical Genetics, University of Oslo, and Department of Medical Genetics, Ullevål University Hospital and Departments of Obstetrics and Gynecology, Aker University Hospital, Oslo, Norway. Sample The cases were 71 women who subsequently developed pre-eclampsia. The controls were 71 healthy, pregnant women matched for age, parity and first trimester body mass index (BMI). Methods Venous blood was drawn from fasting subjects into 5 mL test tubes containing EDTA. Samples were analysed for inflammatory parameters : IL-1-h, IL-6, IL-10, TNF-a, PAI-1, TF (ELISA-technique) and CRP (latex-enhanced immunonephelometric assay), strictly according to the manufacturer's recommendation. Main outcome measures The matched case and control subjects were compared by the paired two-tailed Wilcoxon signed rank test. All P values were two-tailed and P < 0.05 was deemed statistically significant. Results We found no differences in plasma concentrations of PAI-1, IL-1h, IL-6, IL-10, microCRP, TNF-a or TF at 18 weeks of gestation between women who subsequently developed pre-eclampsia and matched control women. Conclusion In contrast to findings from women with overt pre-eclampsia, the present study indicates that there are no indications of intensified systemic inflammatory response at 18 weeks of gestation in women who later develop pre-eclampsia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia

Djurovic¹

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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“…99 As a potent initiator of coagulation, tissue factor has critical functions in haemostasis and thrombogenesis. 100 Several studies have established a link between blood coagulation and cancer; more specifically between tissue factor and tumour metastasis. There is an increased incidence of thromboembolic disease in patients with cancers and, therefore, haemostatic abnormalities are common in these patients.…”

Section: Invasive Supportmentioning

confidence: 99%

The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth

Ronquist

Nilsson

2004

Prostate Cancer Prostatic Dis

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Prostasomes are submicron secretory granules synthesized, stored and secreted by the epithelial cells of the human prostate gland. They are membrane-surrounded also in their extracellular appearance and the membrane architecture is composite. They are believed to be life-giving and act as protectors of the spermatozoa in the lower and upper female genital tract on their way to the ovum. Hence, the prostasomes are immunosuppressive and inhibitory of complement activation. Further, they promote sperm's forward motility and have antioxidant and antibacterial capacities. The prostasomes with their many composite abilities seem to turn against the host cell after the age of 50 y being conducive to the transition of the normal prostate epithelial cell into a neoplastic cell and therewith lay the foundations of the very high prevalence of prostate cancer of men of more than 50 y of age. Prostate Cancer and Prostatic Diseases (2004) 7, 21-31. doi:10.1038/sj.pcan.4500684 Keywords: prostasomes Prostate cancerProstate cancer is the most common cancer in men in Europe, North America, and some parts of Africa. Incidence of prostate cancer is increasing steadily in most countries. Incidence and death rates differ according to race and geographical location. 1 Different autopsy studies performed in Western and Oriental populations have shown that the prevalence of prostate cancer is significantly higher than its incidence. Comparative assessments of these studies have provided similar prevalence rates in different races and geographical areas. 2 The differences in the incidence of prostate cancer in different races and geographical areas and the different progression of this incidence in populations of a race living in a foreign geographical area, strengthen the hypothesis that genetic and lifestyle factors are responsible for the difference in post-induction progression of prostate cancer. 3,4 The incidence rate of clinically apparent prostate cancer is eight-fold higher in the United States than in Japan, while the prevalence of latent prostate cancer, a presumed precursor of clinical prostate cancer, is similar in the two countries. 5 However, the initiating and promoting factors that determine the variability in the natural history of prostate cancer remain unknown. 6 There is a substantial discrepancy between the high incidence of prostate cancer and the extremely low incidence of primary cancer in the seminal vesicles, 7 although the two glands represent neighbouring anatomical locations, both of them being exocrine accessory genital glands and both being under similar hormonal control. Hence, there may be endogenous as well as exogenous factors promotive of prostate cancer development. We hypothesize that prostasomes with their exclusive origin in the prostate gland and with their Received

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“…In health, TF is highly expressed on cells of vascular adventitia but not on the endothelium and other cells in circulating blood [27,28]. Several studies demonstrated that bacterial/viral infections and certain pathophysiological stimuli induce TF expression in monocytes and endothelial cells [29]. This explains the association of certain infectious diseases with hematological complications such as thromboembolism, and septic shock [30,31].…”

Section: Introductionmentioning

confidence: 99%

Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol

Kaur

Roberti

Raul

et al. 2007

Thrombosis Research

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Prevention of cardiovascular disease through nutritional supplements is growing in popularity throughout the world. Multiple epidemiologic studies found that moderate consumption of alcohol, particularly red wine, lowers mortality rates from coronary heart diseases (CHD). Chronic inflammation and atherosclerosis associated with CHD culminate in aberrant intravascular expression of tissue factor (TF), which triggers blood coagulation leading to thrombosis, a major cause for heart attack. We showed earlier that two red wine phenolics, resveratrol and quercetin, suppressed TF induction in endothelial cells. In the present study, we investigated efficacy of seven resveratrol derivatives, which were shown to be effective in regulating cancer cell growth in vitro at much lower concentrations than the parent compound resveratrol, in inhibiting TF induction in peripheral blood mononuclear cells (PBMCs). We also tested possible synergistic effects of resveratrol and quercetin with the other major red wine phenolics in suppression of lipopolysaccharide-induced TF expression in human PBMCs. We found that several resveratrol derivatives were 2-to 10-fold more efficient than resveratrol in inhibiting TF induction. Our study found no evidence for synergism among red wine polyphenolics. These data suggest that structural alterations of resveratrol can be effective in producing potent antithrombotic agents that will have therapeutic potential in the improvement of cardiovascular health and prevention of CHD. Among major red wine phenolics, quercetin appears to be the predominant suppressor of TF induction.

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Cell biology of tissue factor, the principal initiator of blood coagulation

Cited by 401 publications

References 240 publications

Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia

Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia

The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth

Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol

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