Cell calcium and arterial blood pressure

Increase in Functional Ca 2+ Channels in Cerebral Smooth Muscle With Renal Hypertension

“…1 In vascular smooth muscle, [Ca 2ϩ ] i is critical for development and maintenance of force and is one of the principal determinants of vascular tone. 2 Given that increased peripheral vascular resistance and augmented contractile responses to vasoconstrictors are hallmarks of hypertension, it is evident that altered Ca 2ϩ handling in vascular smooth muscle should be considered an important factor in hypertension.…”

“…2 Given that increased peripheral vascular resistance and augmented contractile responses to vasoconstrictors are hallmarks of hypertension, it is evident that altered Ca 2ϩ handling in vascular smooth muscle should be considered an important factor in hypertension. 1,3,4 Several lines of evidence suggest that augmented Ca 2ϩ influx through L-type Ca 2ϩ channels in vascular smooth muscle contributes to hypertension. There is increased basal Ca 2ϩ influx and augmented Ca 2ϩ influx after agonist activation of vascular smooth muscle in hypertension.…”

A Combined High Salt Plus Fructose Diet Mediates Hypertension

“…. Blood pressure is highly regulated by intracellular calcium because an influx of calcium into vascular smooth muscles can result in an intensified muscular morphology, tone, and increasing vascular resistance thus resulting in elevated blood pressure[63,64]. Cirello J et.…”