Cell death in the Schwann cell lineage and its regulation by neuregulin.

Syroid, Daniel E.; Maycox, Peter R.; Burrola, Patrick; Liu, Naili; Wen, Duanzhi; Lee, Kuo‐Fen; Lemke, Greg; Kilpatrick, Trevor J.

doi:10.1073/pnas.93.17.9229

Cited by 224 publications

(210 citation statements)

References 26 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…Although the role of NRG in Schwann cell proliferation and survival is well documented (Dong et al, 1995;Levi et al, 1995;Meyer and Birchmeier, 1995;Grinspan et al, 1996;Mirsky et al, 1996;Syroid et al, 1996;Topilko et al, 1996;Baek and Kim, 1998;Jessen and Mirsky, 2002), the effect of NRG signaling within the peripheral nerve later in development is less clear. NRG expression increases in both motor and sensory neurons as the peripheral nerve matures (Loeb et al, 1999;our unpublished observations).…”

Section: Rapid Axoglial Communication Through Schwann Cell Neurotrophmentioning

confidence: 99%

Rapid Axoglial Signaling Mediated by Neuregulin and Neurotrophic Factors

Esper¹,

Loeb²

2004

J. Neurosci.

View full text Add to dashboard Cite

During peripheral nervous system development, Schwann cells are precisely matched to the axons that they support. This is mediated by axonal neuregulins that are essential for Schwann cell survival and differentiation. Here, we show that sensory and motor axons rapidly release heparin-binding forms of neuregulin in response to Schwann cell-derived neurotrophic factors in a dose-dependent manner. Neuregulin release occurs within minutes, is saturable, and occurs from axons that were isolated using a newly designed chamber slide apparatus. Although NGF and glial cell line-derived neurotrophic factor (GDNF) were the most potent neurotrophic factors to release neuregulin from sensory neurons, GDNF and BDNF were most potent for motor neurons and were the predominant neuregulin-releasing neurotrophic factors produced by cultured Schwann cells. Comparable levels of neuregulin could be released at a similar rate from neurons after protein kinase C activation with the phorbol ester, phorbol 12-myristate 13-acetate, which has also been shown to promote the cleavage and release of neuregulin from its transmembrane precursor. The rapid release of neuregulin from axons in response to Schwann cell-derived neurotrophic factors may be part of a spatially restricted system of communication at the axoglial interface important for proper peripheral nerve development, function, and repair.

show abstract

Section: Rapid Axoglial Communication Through Schwann Cell Neurotrophmentioning

confidence: 99%

Rapid Axoglial Signaling Mediated by Neuregulin and Neurotrophic Factors

Esper¹,

Loeb²

2004

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Neuregulins act as the most potent mitogens for precursor Schwann cells in vitro (Dong et al, 1995), and they reduce apoptosis of mature Schwann cells upon axotomy (Grinspan et al, 1996), probably re¯ecting a role in attaining the appropriate ratio of neurons to Schwann cells in adults (Syroid et al, 1996). An in vivo e ect on synaptic Schwann cell survival after denervation has been recently demonstrated (Trachtenberg and Thompson, 1996).…”

Section: Introductionmentioning

confidence: 99%

Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation

et al. 1997

View full text Add to dashboard Cite

Two receptor tyrosine kinases, ErB-3 and ErbB-4, mediate signaling by Neu di erentiation factors (NDFs, also called neuregulins), while ErbB-1 and ErbB-2 serve as co-receptors. We show that the two NDF/neuregulin receptors di er in spatial and temporal expression patterns: The kinase-defective receptor, ErbB-3, is expressed primarily in epithelial layers of various organs, in the peripheral nervous system, and in adult brain, whereas ErbB-4 is restricted to the developing central nervous system and to the embryonic heart. An example of alternating expression of the two receptors is provided by the developing cerebellum: During postnatal cerebellar development, ErbB-4 expression slightly decreases along with a decline in NDF transcription, whereas ErbB-3 expression commences after the peak of neurogenesis. To study functional di erences, we established primary brain cultures and found that ErbB-3 was expressed only in oligodendrocytes, whereas ErbB-4 expression was shared by oligodendrocytes, astrocytes and neurons. Blocking the action of endogenous NDF in vitro, by using a soluble form of ErbB-4, accelerated neurite outgrowth in both primary cultures and in neuronal-type cultures of the P19 teratocarcinoma, suggesting an inhibitory e ect of NDF on neural di erentiation. Apparently, ErbB-3 is associated with proliferation of P19 cells, whereas ErbB-4 correlates with a di erentiated phenotype. We conclude that the two NDF receptors play distinct, rather than redundant, developmental and physiological roles.

show abstract

“…In addition to its known roles as a cellular differentiation factor, NRG-1 has also been shown to influence cellular proliferation, apoptosis, survival, and fate under certain conditions, depending on the cell type and NRG isoform (14)(15)(16)(17)(18)(19). Therefore, we tested whether NRG-1 treatment led to selective proliferation of lacZϩ cells.…”

Section: Neuregulin-1 Converts Murine Contractile Cardiomyocytes Intomentioning

confidence: 99%

Neuregulin-1 promotes formation of the murine cardiac conduction system

Rentschler

Zander²,

Meyers³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

224

202

View full text Add to dashboard Cite

The cardiac conduction system is a network of cells responsible for the rhythmic and coordinated excitation of the heart. Components of the murine conduction system, including the peripheral Purkinje fibers, are morphologically indistinguishable from surrounding cardiomyocytes, and a paucity of molecular markers exists to identify these cells. The murine conduction system develops in close association with the endocardium. Using the recently identified CCS-lacZ line of reporter mice, in which lacZ expression delineates the embryonic and fully mature conduction system, we tested the ability of several endocardial-derived paracrine factors to convert contractile cardiomyocytes into conduction-system cells as measured by ectopic reporter gene expression in the heart. In this report we show that neuregulin-1, a growth and differentiation factor essential for ventricular trabeculation, is sufficient to induce ectopic expression of the lacZ conduction marker. This inductive effect of neuregulin-1 was restricted to a window of sensitivity between 8.5 and 10.5 days postcoitum. Using the whole mouse embryo culture system, neuregulin-1 was shown to regulate lacZ expression within the embryonic heart, whereas its expression in other tissues remained unaffected. We describe the electrical activation pattern of the 9.5-days postcoitum embryonic mouse heart and show that treatment with neuregulin-1 results in electrophysiological changes in the activation pattern consistent with a recruitment of cells to the conduction system. This study supports the hypothesis that endocardial-derived neuregulins may be the major endogenous ligands responsible for inducing murine embryonic cardiomyocytes to differentiate into cells of the conduction system.

show abstract

Cell death in the Schwann cell lineage and its regulation by neuregulin.

Cited by 224 publications

References 26 publications

Rapid Axoglial Signaling Mediated by Neuregulin and Neurotrophic Factors

Rapid Axoglial Signaling Mediated by Neuregulin and Neurotrophic Factors

Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation

Neuregulin-1 promotes formation of the murine cardiac conduction system

Contact Info

Product

Resources

About