Cell death in the ventral region of the neural retina during the early development of the chick embryo eye

Martı́n-Partido, Gervasio; Rodríguez‐Gallardo, Lucía; Alvarez, I.; Navascués, Julio

doi:10.1002/ar.1092220308

Cited by 48 publications

(57 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This decrease was more evident in the proximal pole of the cup (compare Fig. 6H,I with 6E,F) corresponding to the region where the optic fissure normally forms (Martín-Partido et al, 1988;Ozeki et al, 2000;Silver and Hughes, 1973). Altogether, these data indicate that Bmp7-mediated signalling controls proliferation and programmed cell death of RF precursors.…”

Section: Bmp7 Regulates Proliferation and Apoptosis During Optic Fissmentioning

confidence: 62%

Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH

et al. 2006

View full text Add to dashboard Cite

The optic disc develops at the interface between optic stalk and retina, and enables both the exit of visual fibres and the entrance of mesenchymal cells that will form the hyaloid artery. In spite of the importance of the optic disc for eye function, little is known about the mechanisms that control its development. Here, we show that in mouse embryos, retinal fissure precursors can be recognised by the expression of netrin 1 and the overlapping distribution of both optic stalk (Pax2, Vax1) and ventral neural retina markers (Vax2, Raldh3). We also show that in the absence of Bmp7, fissure formation is not initiated. This absence is associated with a reduced cell proliferation and apoptosis in the proximoventral quadrant of the optic cup, lack of the hyaloid artery, optic nerve aplasia, and intra-retinal misrouting of RGC axons. BMP7 addition to organotypic cultures of optic vesicles from Bmp7 -/-embryos rescues Pax2 expression in the ventral region, while follistatin, a BMP7 antagonist, prevents it in early, but not in late, optic vesicle cultures from wild-type embryos. The presence of Pax2-positive cells in late optic cup is instead abolished by interfering with Shh signalling. Furthermore, SHH addition re-establishes Pax2 expression in late optic cups derived from ocular retardation (or) embryos, where optic disc development is impaired owing to the near absence of SHH-producing RGC. Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc.

show abstract

Section: Bmp7 Regulates Proliferation and Apoptosis During Optic Fissmentioning

confidence: 62%

Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In various fishes, it is not always easy to isolate the peaks of morphogenetic and early neural cell death, probably due to the accelerated initial development when compared to higher vertebrates (Candal et al, 2005;Iijima and Yokohama, 2007). In chick (Martín-Partido et al, 1988), the numbers reported are very similar for the morphogenetic and early neural phases (1515 vs. 1680 pyknotic fragments, respectively). In the mouse, it is again impossible to isolate these peaks of cell death (Péquignot et al, 2003).…”

Section: Early Neural Cell Death Affecting Retinal Ganglion Cell Genementioning

confidence: 73%

Early neural cell death: numbers and cues from the developing neuroretina

Valenciano¹,

Boya²,

Rosa³

2009

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Programmed cell death is a well established key process required for proper development of the nervous system. The regulatory and executor mechanisms controlling survival/ death of projection neurons, as well as of other types of differentiated neurons and glial cells, have been studied intensely during neural development. Much less attention has been paid to earlier cell death events affecting neuroepithelial cells and recently born neurons and glial cells. We review here the reports on cell death during vertebrate retina development, our model system for many years, which has provided clear evidence of the importance of early neural cell death. We tentatively categorize the available observations in three death phases, namely morphogenetic cell death, early neural cell death and neurotrophic cell death. The magnitude and the precise regulation of the early phases of cell death are fully comparable to the much better characterized neurotrophic cell death. Therefore, early neural cell death deserves a profound dedicated study; this will help to obtain an integrated understanding of the development of the retina and other parts of the vertebrate nervous system.

show abstract

“…Apoptosis has also been analyzed during the development of the chick retina (Cuadros and Ríos, 1988;Martín-Partido et al, 1988;Frade et al, 1996;Díaz et al, 1999Díaz et al, , 2000Mayordomo et al, 2003). Two waves of programmed cellular death occur in the developing chicken retina.…”

Section: Birdsmentioning

confidence: 99%

Cell death in the developing vertebrate retina

Vecino¹,

Hernández²,

Garcı́a³

2004

Int. J. Dev. Biol.

View full text Add to dashboard Cite

Programmed cell death occurs naturally, as a physiological process, during the embryonic development of multicellular organisms. In the retina, which belongs to the central nervous system, at least two phases of cell death have been reported to occur during development. An early phase takes place concomitant with the processes of neurogenesis, cell migration and cell differentiation. A later phase affecting mainly neurons occurs when connections are established and synapses are formed, resulting in selective elimination of inappropriate connections. This pattern of cell death in the developing retina is common among different vertebrates. However, the timing and magnitude of retinal cell death varies among species. In addition, a precise regulation of apoptosis during retinal development has been described. Factors such as neurotrophins, among many others, and electrical activity influence the survival of retinal cells during the course of development. In this paper, we present a summary of these different aspects of programmed cell death during retinal development, and examine how these differ among different species.

show abstract

Cell death in the ventral region of the neural retina during the early development of the chick embryo eye

Cited by 48 publications

References 38 publications

Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH

Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH

Early neural cell death: numbers and cues from the developing neuroretina

Cell death in the developing vertebrate retina

Contact Info

Product

Resources

About