1999
DOI: 10.1292/jvms.61.1093
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Cell Death of Uterine Natural Killer Cells in Murine Placenta during Placentation and Preterm Periods.

Abstract: ABSTRACT. In the murine uterus granulated metrial gland (GMG) cells appear only during normal pregnancy. GMG cells belong to a member of natural killer (NK) cells and play an important role in fetus survival and placental growth. Our previous study revealed that mouse GMG/uterine NK (uNK) cells in the late pregnancy rapidly disappear from the uterus, due to the degenerative change classified as necrosis. But there are few reports regarding appearance and morphology of uNK cells during late pregnancy. We examin… Show more

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Cited by 23 publications
(13 citation statements)
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“…In the current investigation we demonstrated that both adhesion and clustering of CD56+CD16−CD3− NK cells depended on either SELL and/or ITGA4, suggesting the alternative or supplementary explanation that clustered attachment of CD56+CD16−CD3− NK cells is a response to elevated expression of trafficking ligands in the substrate. This explanation is consistent with reports that peak uNK cell numbers are achieved in mouse uterus between gd8-14 depending on the strain [34][35][36] with gd10-12 usually reported as their numerically most abundant days in C56BL6 [34].…”
Section: Discussionsupporting
confidence: 92%
“…In the current investigation we demonstrated that both adhesion and clustering of CD56+CD16−CD3− NK cells depended on either SELL and/or ITGA4, suggesting the alternative or supplementary explanation that clustered attachment of CD56+CD16−CD3− NK cells is a response to elevated expression of trafficking ligands in the substrate. This explanation is consistent with reports that peak uNK cell numbers are achieved in mouse uterus between gd8-14 depending on the strain [34][35][36] with gd10-12 usually reported as their numerically most abundant days in C56BL6 [34].…”
Section: Discussionsupporting
confidence: 92%
“…In addition, uNK cytoplasm starts to expand and the cells begin to secrete IFN-g [Croy et al 2003a], TNF-a [Wu et al 2006], VEGF, and placenta growth factor [Hanna et al 2006]. Peak numbers of uNK cells are attained by d10.5 during normal murine pregnancy and these numbers start to decline at approximately d12.5 [Delgado et al 1996;Kusakabe et al 1999]. During mid-to-late gestation in the mouse, there are fewer uNK cells in the decidua basalis and are predominantly localized to the mesometrial gland [Peel 1989].…”
Section: Uterine Natural Killer Cellsmentioning
confidence: 99%
“…Our previous study proposed that the apoptotic cell death of uNK cells contributes to their decrease during late pregnancy and disappearance from the implantation site before parturition [9]. It is possible that the FasL and Fas system has an important role in the process that decreases uNK cells.…”
Section: Discussionmentioning
confidence: 99%
“…An abnormality in cell appearance of uNK cells can induce low fertility in pregnant mice [8]. We previously reported that the number of uNK cells suddenly decreases during late pregnancy period, and that the decrease is d e p e n d e n t o n a p o p t o t i c c e l l d e a t h [ 9 ] . Furthermore, in pregnant lpr/lpr mice, retardation of the degenerative change in uNK cells was observed, as compared with wild-type mice [10].…”
mentioning
confidence: 99%