Cell Dysfunction as a Precursor of Pulmonary Disease

Green, Gareth M.; Speizer, Frank E.; Vigersky, Robert A.; Kass, Edward H.; Goldsmith, John R.; Discher, David P.; Rymzo, Walter T.; Holland, Walter W.; Lawther, P. J.; Conwell, Donald P.; Cochrane, A. L.; Tayl, Henry L.

doi:10.2307/3349267

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…The lack of a nonspecific effect against a heterologous organism, however, indicates that specific immunologic mechanisms were involved in the enhancement of intrapulmonary killing and the prevention of the virus-induced inhibition of pulmonary bactericidal activity. The lack of a nonspecific effect against S. aureus and the magnitude of the specific effect against P. mirabilis rules out the possibility that enhancement of pulmonary bactericidal activity was due to a nonspecific effect of particulate inhalation (15) brought about by the aerogenic immunization procedure.…”

Section: Discussionmentioning

confidence: 99%

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

Jakab

Green

1973

J. Clin. Invest.

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Bacterial multiplication in the lung associated with murine Sendai virus pneumonia is caused by virus-induced defects in pulmonary bactericidal mechanisms. The nature of this effect has been studied in animals immunized against the challenge bacteria. Mice were immunized against Proteus mirabilis by intraperitoneal inoculation and by aerosol inhalation. After the development of immunity, mice were infected aerogenically with 10O TCIDso of Sendai virus. 7 days later, during the height of the bronchial inflammation and pulmonary consolidation, the mice were challenged with an aerosol of viable i'S-labeled Proteus mirabilis or 8P-labeled Staphylococcus aureus.Nonimmunized virus-infected animals showed marked impairment of pulmonary bactericidal activity with subsequent multiplication of the bacterial strain in the case of Proteus mirabilis. Immunized nonvirus-infected animals showed enhancement of pulmonary bactericidal activity for the homologous and heterologous strains in comparison with nonimmunized animals. Virus-infected animals immunized by aerosol showed enhanced bactericidal activity against the homologous but not the heterologous bacterial strain. Neither virus infection nor immunization had a significant effect on the transport of particles in the lung. The data demonstrated that the bacterial multiplication associated with the virus pneumonia was prevented by preceding immunization against the homologous challenge organism. The data suggest a mechanism for controlling bacterial multiplication associated with virus pneumonias.

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Section: Discussionmentioning

confidence: 99%

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

Jakab

Green

1973

J. Clin. Invest.

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show abstract

“…In naturally occurring chronic pulmonary disease in animals, there is enhanced susceptibility to bacterial infection and impairment of the bactericidal mechanism of the llUlg. 7 In comparison with specific pathogen-free rats, animals with early chronic pulmonary disease have a significant depression of pulmonary bactericidal activity. Further impairment of this cellular mechanism may be induced by factors such as nutrition, hormonal imbalance, viral infection, metabolic factors, and air pollutants.…”

mentioning

confidence: 99%

Cell Dysfunction as a Precursor of Pulmonary Disease

Cited by 2 publications

References 8 publications

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

Immune Enhancement of Pulmonary Bactericidal Activity in Murine Virus Pneumonia

Cell Dysfunction as Pathogenetic Determinant in Chronic Bronchopulmonary Disease

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