Cell free DNA concentration and serum leptin level as predictors of mortality in a sample of septic Egyptian children

Abdelaal, Amaal A.; Elghobary, Hany; Ibrahiem, Sally K; Sleem, Hala M.

doi:10.1016/j.jcrc.2017.10.020

Journal of Critical Care

2018

DOI: 10.1016/j.jcrc.2017.10.020

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Cell free DNA concentration and serum leptin level as predictors of mortality in a sample of septic Egyptian children

Amaal A. Abdelaal

Hany Elghobary

Sally K Ibrahiem

et al.

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2024

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Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis

Dadam,

Hien,

Makram

et al. 2024

PLoS ONE

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Background Sepsis remains a major cause of mortality in intensive care units (ICUs). Prompt diagnosis and effective management are imperative for better outcomes. In this systematic review and meta-analysis, we explore the potential of circulating cell-free DNA (cfDNA), as a promising tool for early sepsis detection and prognosis assessment, aiming to address limitations associated with traditional diagnostic methods. Methods Following PRISMA guidelines, we collected relevant literature from thirteen databases. Studies were included if they analyzed quantitative diagnostic or prognostic cfDNA levels in humans in case of sepsis. We collected data on basic study characteristics, baseline patient demographics (e.g. age and sex), and cfDNA levels across different stages of sepsis. Pooled SMD with 95%-CI was calculated, and Comprehensive Meta-Analysis (CMA) software facilitated meta-analysis. Receiver operating characteristic (ROC) curves were generated to assess cfDNA’s combined sensitivity and specificity in diagnostics and prognostics. Results We included a final of 44 studies, of which, only 32 with 2950 participants were included in the meta-analysis. cfDNA levels were higher in septic patients compared to healthy controls (SMD = 3.303; 95%-CI [2.461–4.145], p<0.01). Furthermore, cfDNA levels were higher in non-survivors than survivors (SMD = 1.554; 95%-CI [0.905–2.202], p<0.01). Prognostic studies demonstrated a pooled sensitivity and specificity of 0.78, while diagnostic studies showed a sensitivity of 0.81 and a specificity of 0.87. Conclusion These findings show that cfDNA levels are significantly higher in sepsis patients compared to control groups and non-survivors in comparison to survivors among both adult and pediatric populations.

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Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis

Dadam,

Hien,

Makram

et al. 2024

PLoS ONE

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show abstract

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Cell free DNA concentration and serum leptin level as predictors of mortality in a sample of septic Egyptian children

Cited by 1 publication

References 38 publications

Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis

Role of cell-free DNA levels in the diagnosis and prognosis of sepsis and bacteremia: A systematic review and meta-analysis

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