2024
DOI: 10.1101/2024.10.15.24315518
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Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response

Jiaqi Liu,
Yalun Li,
Wanxiangfu Tang
et al.

Abstract: The fragmentomics-based cell-free DNA (cfDNA) assays have recently demonstrated remarkable capabilities in identifying various cancers from non-conditional healthy controls. However, their accuracy in differentiating early-stage cancers from benign lesions, especially with inconclusive imaging results, remains unclear. In breast cancer, imaging-based screening methods often yield high false-positive rates, particularly in women with breast nodules, leading to unnecessary biopsies and increasing patient discomf… Show more

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