Cell Growth Inhibitory Glycosides from Asclepias amplexicaulis

Abstract

Our prior study (1) of the roots from Asclepias amplexicaulis Sm (Asclepiadaceae) resulted in the isolation and identification of amplexoside A (1), which had shown cell growth inhibitory activity against the NCI KB cell line from a human nasopharnyx carcinoma (2) . In this report, we wish to present tentative structures for two additional glycosides from this plant, namely, amplexoside B (2) and amplexoside C (3) , which were found to have KB cell line ED50 values (2) of 3.9 and 0.14, re-

Plant Anticancer Agents, XLIV. Cytotoxic Constituents from Stizophyllum riparium

“…A more detailed study of the mechanism of action of 4 against P-388 cells is in progress. While triterpene esters of the ursene type do not appear to have been reported to possess Cytotoxic Constituents from Stizophyllum cytotoxic activity previously, a number of other plant-derived pregnane derivatives are known to be inhibitors of cell growth (29)(30)(31)(32). EXPERIMENTAL General experimental procedures.-Melting points were determined using a Kofler hotstage instrument and are uncorrected.…”