Cell Immobilization Strategies for Tissue Engineering: Recent Trends and Future Perspectives

Kulkarni, Pallavi; Parkale, Rohit; Khare, Surbhi; Kumar, Prasoon; Arya, Neha

doi:10.1007/978-981-15-7998-1_2

Cited by 2 publications

(11 citation statements)

References 250 publications

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“…Over the years, researchers worldwide have studied different immobilization methods and materials. 20,25,26 In the 1970s, natural polymers such as alginate gained popularity owing to their biocompatibility and gel-forming properties. Adsorption-based methods, where cells were attached to support materials, also emerged.…”

Section: Historymentioning

confidence: 99%

“…10 Mammalian cell immobilization in bioreactors involves trapping cells in substrate pores and providing sufficient surface area for attachment, communication, migration, differentiation and proliferation. 25 The design of a bioreactor for mammalian cell culture should consider various parameters such as perfusion system, pore size, surface topology, and mechanical, thermal and chemical properties. 194 Perfusion systems, for example, enable forceful passage of culture medium through solid porous 3D scaffolds, enhancing nutrient transport and providing mechanical stimuli to cells within the scaffold's pores.…”

Section: Bioreactors For Cell Immobilizationmentioning

confidence: 99%

“…STRs have also enhanced the formation of beta cell pseudo-islets and insulin secretion compared with static culture, and they have been used for measuring oxygen consumption in pancreatic islets to assess cell viability. 25 Fluidized bed reactor (FBR)…”

Section: Stirred Tank Reactor (Str)mentioning

confidence: 99%

“…These modifications have shown improved viability of encapsulated hepatic cells and potential applications in bioartificial liver systems. 25 FBRs offer advantages such as good heat transfer and uniform particle mixing without the need for agitators, yet they require high maintenance and face challenges in matching the feed and fluidization rate. 207 Wu et al 208…”

Section: Stirred Tank Reactor (Str)mentioning

confidence: 99%

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Immobilization: the promising technique to protect and increase the efficiency of microorganisms to remove contaminants

Najim,

Radeef,

al‐Doori

et al. 2024

J of Chemical Tech & Biotech

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Biodegradation is one of the most economical methods and usually no production of toxic by‐products. In general, this approach is favored because it offers reduced expenses and the potential for complete mineralization. In order to enhance the viability and longevity of the bioremediation agents within polluted areas, it becomes necessary to immobilize the cells. Cell immobilization refers to the procedure of confining intact cells to specific areas within a device or material, without compromising their essential biological functions. A wide variety of carriers and approaches have been used for the restriction of various cells. Immobilization techniques, such as microencapsulation, have opened up new possibilities in biotechnology by facilitating the development of artificial organs, cell therapies, and drug delivery systems. Researchers have found promising outcomes in various applications through the immobilization of microorganisms. This approach enhances stability, reusability, and catalytic efficiency, making immobilization a valuable strategy for biocatalysis, bioremediation, and other biotechnological processes. Notably, the use of immobilized microorganisms has led to significant improvements in the removal of pollutants, with some studies achieving 100% efficiency. When comparing the degradation of pollutants between free and immobilized microorganisms over the same time period, the results demonstrated that immobilized microorganisms achieved a removal efficiency of more than 21% than the free microbial consortium. The primary objective of this review is to give an overview of the key scientific aspects related to bioremediation of various pollutants using immobilized cell, with a particular focus on the techniques to entrap the cells.This article is protected by copyright. All rights reserved.

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Section: Historymentioning

confidence: 99%

Section: Bioreactors For Cell Immobilizationmentioning

confidence: 99%

Section: Stirred Tank Reactor (Str)mentioning

confidence: 99%

Section: Stirred Tank Reactor (Str)mentioning

confidence: 99%

See 2 more Smart Citations

Immobilization: the promising technique to protect and increase the efficiency of microorganisms to remove contaminants

Najim,

Radeef,

al‐Doori

et al. 2024

J of Chemical Tech & Biotech

View full text Add to dashboard Cite

show abstract

“…In order to prevent the immune system attacking transplanted cells, cell encapsulation is a very versatile and useful technique that allows the bidirectional exchange of oxygen, nutrients, waste products and therapeutic proteins between host and encapsulated cells [ 170 ], a technique that involves the localization of intact cells to specific regions in a device or material without the loss of the requisite biological function. Immobilization of cells can generally be performed through physical adsorption, encapsulation, entrapment and self-aggregation [ 171 ].…”

Section: Emerging Therapies Using Biopolymersmentioning

confidence: 99%

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

Gardikiotis

Cojocaru

Mihai

et al. 2022

IJMS

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Wound dressing design is a dynamic and rapidly growing field of the medical wound-care market worldwide. Advances in technology have resulted in the development of a wide range of wound dressings that treat different types of wounds by targeting the four phases of healing. The ideal wound dressing should perform rapid healing; preserve the body’s water content; be oxygen permeable, non-adherent on the wound and hypoallergenic; and provide a barrier against external contaminants—at a reasonable cost and with minimal inconvenience to the patient. Therefore, choosing the best dressing should be based on what the wound needs and what the dressing does to achieve complete regeneration and restoration of the skin’s structure and function. Biopolymers, such as alginate (ALG), chitosan (Cs), collagen (Col), hyaluronic acid (HA) and silk fibroin (SF), are extensively used in wound management due to their biocompatibility, biodegradability and similarity to macromolecules recognized by the human body. However, most of the formulations based on biopolymers still show various issues; thus, strategies to combine them with molecular biology approaches represent the future of wound healing. Therefore, this article provides an overview of biopolymers’ roles in wound physiology as a perspective on the development of a new generation of enhanced, naturally inspired, smart wound dressings based on blood products, stem cells and growth factors.

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Cell Immobilization Strategies for Tissue Engineering: Recent Trends and Future Perspectives

Cited by 2 publications

References 250 publications

Immobilization: the promising technique to protect and increase the efficiency of microorganisms to remove contaminants

Immobilization: the promising technique to protect and increase the efficiency of microorganisms to remove contaminants

Borrowing the Features of Biopolymers for Emerging Wound Healing Dressings: A Review

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