Cell interaction at the maternal-embryonic interface during implantation in the mouse

Smith, Agnes F.; Wilson, I. B.

doi:10.1007/bf00218936

Cited by 35 publications

(27 citation statements)

References 24 publications

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“…94 Decidual cells adjacent to rat implantation chambers are also strongly positive for tissue transglutaminase, an enzyme catalyzing cross-linking reactions and whose activation is associated with apoptosis. 95 Investigations in the mouse 96 and in the rat 97 confirmed the digestion of displaced epithelial cells by nearby trophoblasts. When histological sections through rat implantation sites are analyzed for acid phosphatase activity, however, highest levels of this marker of phagocytosis are found in decidual cells, 95 suggesting that both trophoblast and decidual cell types are likely to participate in the elimination of dying cells from the regressing area.…”

Section: Cell Death In the Uterine Epitheliummentioning

confidence: 87%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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The aim of this review is to summarize the information currently available regarding the occurrence of apoptosis in the developing embryo and in the receptive uterus during the peri-implantation period of gestation. Cell death is detected in the inner cell mass of late pre-implantation embryos as the result of an eliminative process that helps trim the embryonic cell lineages of surplus or dysfunctional stem cells. Cell death is also detected in the epiblastic core of early postimplantation embryos, where the process is implicated in the formation of the pro-amniotic cavity. On the maternal side, uterine epithelial cells situated around the attachment site undergo cell death during the initial phase of implantation in order to facilitate embryo anchorage and access to maternal blood supply. Uterine stromal cells closest to the implantation chamber first transform into decidual cells and then commit suicide to make room for the rapidly growing embryo. Although apoptosis is well recognized as a crucial determinant of successful peri-implantation development, our understanding of the cellular and molecular mechanisms regulating this process clearly lags behind the comprehension of cell death control in other systems.

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Section: Cell Death In the Uterine Epitheliummentioning

confidence: 87%

Apoptosis at the time of embryo implantation in mouse and rat

1999

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“…Close membrane apposition between trophoblast and uterine epithelial cells occurred in the Chinese hamster, but no distinct intercellular junctions between these cell types were seen. Potts (1968) described desmosomes between trophoblast and epithelial cells in the mouse, while Smith and Wilson (1974) found mouse trophoblast cells attached to uterine epithelium by primitive junctions. In another study, however, no junctions between these cell types were observed in the mouse or rat (Parr et al, 1987).…”

Section: Discussionmentioning

confidence: 98%

Blastocyst implantation in the chinese hamster (Cricetulus griseus)

1990

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Embryonic development of the Chinese hamster (Cricetulus griseus) was studied from the onset of implantation to the formation of the parietal yolk sac placenta. Implantation began on day 6 of pregnancy, when the embryo became fixed to the uterine luminal epithelium. At this time there was no zona pellucida, and microvilli of the trophoblast and uterine epithelium were closely apposed. Stromal cells immediately adjacent to the implantation chamber began to enlarge and accumulate glycogen. By day 7 the mural trophoblast penetrated the luminal epithelium in discrete area. The trophoblast appeared to phagocytize uterine epithelial cells, although epithelium adjoining the points of penetration was normal. In other areas nascent apical protrusions from the uterine epithelium indented the surface of the trophoblast. The epiblast had enlarged and both visceral and parietal endoderm cells were present. The well-developed decidual cells were epithelioid and completely surrounded the implantation chamber. On day 8 the uterine epithelium had disappeared along the mural surface of the embryo. The embryonic cell mass was elongated and filled the yolk sac cavity. Reichert's membrane was well developed. The uterine epithelial basal lamina was largely disrupted, and the trophoblast was in direct contact with decidual cells. Primary and secondary giant trophoblast cells were present and in contact with extravasated maternal blood. The mural trophoblast formed channels in which blood cells were found in close proximity to Reichert's membrane. Decidual cells were in contact with capillary epithelium and in some cases formed part of the vessel wall. Structural changes occurring in the embryo and endometrium during implantation in the Chinese hamster are described for the first time in this report and are compared to those described for some other myomorph rodents.

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“…Under the influence of either hormone alone, change in the apical plasma membrane is mostly limited to alterations in the height and frequency of microvilli [1,2,3 for review]. However, during early pregnancy when progesterone and oestrogen act together in the peri-implantation period leading to uterine receptivity for implantation of the blastocyst, the apical plasma membrane of uterine epithelial cells undergoes a more marked form of structural change during which over the several days of early pregnancy, and beginning as early as d 2 of pregnancy, it gradually loses regular microvilli and becomes very flat [2,[4][5][6][7]. Indeed, the membranes of uterine epithelial and trophoblast cells in the implantation chamber come to run more or less parallel all along the area of contact as more generally do the membranes of opposing uterine epithelial cells outside the implantation chamber especially in species with uterine closure [8,9].…”

Section: The Apical Plasma Membrane In Rodentsmentioning

confidence: 99%

Uterine receptivity and the plasma membrane transformation

2004

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This review begins with a brief commentary on the diversity of placentation mechanisms, and then goes on to examine the extensive alterations which occur in the plasma membrane of uterine epithelial cells during early pregnancy across species. Ultrastructural, biochemical and more general morphological data reveal that strikingly common phenomena occur in this plasma membrane during early pregnancy despite the diversity of placental types-from epitheliochorial to hemochorial, which ultimately form in different species. To encapsulate the concept that common morphological and molecular alterations occur across species, that they are found basolaterally as well as apically, and that moreover they are an ongoing process during much of early pregnancy, not just an event at the time attachment, the term 'plasma membrane transformation' is suggested which also emphasises that alterations in this plasma membrane during early pregnancy are key to uterine receptivity. INTRODUCTIONContact between the plasma membrane of uterine epithelial cells and that of the trophoblast is a common beginning to implantation in most species studied so far. This is perhaps not surprising since uterine epithelial cells are the first site of contact between maternal and foetal tissue at the beginning of blastocyst attachment and implantation. The similarities in these early events of the uterine response during early pregnancy and placentation however, go further than mere contact between opposing surfaces. A now considerable body of evidence indicates that the behaviour of the plasma membrane of the uterine epithelial cells during early pregnancy has many common aspects across species ranging from viviparous lizards to human beings and that moreover, these similarities exist regardless of the placental type which ultimately develops. This review pays special attention to events at the cellular level in uterine epithelial cells and to the plasma membrane in particular, but does so within the wider context of uterine receptivity for implantation across species.

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Cell interaction at the maternal-embryonic interface during implantation in the mouse

Cited by 35 publications

References 24 publications

Apoptosis at the time of embryo implantation in mouse and rat

Apoptosis at the time of embryo implantation in mouse and rat

Blastocyst implantation in the chinese hamster (Cricetulus griseus)

Uterine receptivity and the plasma membrane transformation

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