Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

Vogels, O.J.M.; Broere, C.A.J.; Laak, H.J. ter; Donkelaar, Hans J. ten; Nieuwenhuys, Rudolf; Schulte, B. P. M.

doi:10.1016/0197-4580(90)90056-6

Cited by 265 publications

(181 citation statements)

References 46 publications

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“…A possible common candidate accounting for the loss of synchronization could be the profound loss of cortical cholinergic projections from the basal nucleus of Meynert, since this is a characteristic of AD, DLB and PDD (Braak et al 2003;Londos et al 2002;Lippa et al 1999;Cullen and Halliday 1998;Lehericy et al 1993;Vogels et al 1990;Candy et al 1983). Involvement of the cholinergic system is supported by an animal study, in which lesioning of the cholinergic system resulted in a reduction of long distance intrahemispheric as well as interhemispheric coherence (Holschneider et al 1999).…”

Section: Pddmentioning

confidence: 68%

MEG resting state functional connectivity in Parkinson’s disease related dementia

et al. 2008

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Parkinson's disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer's disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD.

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Section: Pddmentioning

confidence: 68%

MEG resting state functional connectivity in Parkinson’s disease related dementia

et al. 2008

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“…These reductions are analogous to the loss of forebrain cholinergic neurons seen in both Down syndrome (Casanova et al, 1985;Head et al, 2001;Mann and Esiri, 1989) and Alzheimer's Disease (Candy et al, 1986;Coyle, Price and DeLong, 1983;Vogels et al, 1990;Whitehouse et al, 1985).…”

Section: Introductionmentioning

confidence: 81%

Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome

Chang

Gold

2008

Neurobiology of Learning and Memory

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Spatial working memory and the ability of a cholinesterase inhibitor to enhance memory were assessed at 4, 10, and 16 months of ages in control and Ts65Dn mice, a partial trisomy model of Down syndrome, with possibly significant relationships to Alzheimer's Disease as well. In addition, ACh release during memory testing was measured in samples collected from the hippocampus using in vivo microdialysis at 4, 10, and 22-25 months of age. When tested on a four-arm spontaneous alternation task, the Ts65Dn mice exhibited impaired memory scores at both 4 and 10 months. At 16 months, control performance had declined toward that of the Ts65Dn mice and the difference in scores across genotypes was not significant. Physostigmine (50 μg/kg) fully reversed memory deficits in the Ts65Dn mice in the 4-month-old group but not in older mice. Ts65Dn and control mice exhibited comparable baseline levels of ACh release at all ages tested; these levels did not decline significantly across age in either genotype. ACh release increased significantly during alternation testing only in the young Ts65Dn and control mice. However, the increase in ACh release during alternation testing was significantly greater in control than Ts65Dn mice at this age. The controls exhibited a significant age-related decline in the testing-related increase in ACh release. With only a small increase during testing in young Ts65Dn mice, the age-related decline in responsiveness of ACh release to testing was not significant in these mice. Overall, these results suggest that diminished responsiveness of ACh release in the hippocampus to behavioral testing may contribute memory impairments in Ts65Dn mice.

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“…Ch4 group (Figs 1C-E, 3A, 4-6)-Cell aggregates in the subpallidal region, largely correspond to the basal nucleus of Meynert as defined by Vogels et al, (1990) andDe Lacalle et al, (1991). We did not differentiate subcomponents of the Ch4 compartment as suggested by Mesulam et al, (1983).…”

Section: Ch3 Group (Figs 1b 3a-b)-thementioning

confidence: 99%

Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

et al. 2008

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The basal forebrain contains several interdigitating anatomical structures, including the diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell groups underneath the globus pallidus that bridge the centromedial amygdala to the bed nucleus of the stria terminalis. Among the cell populations, the magnocellular, cholinergic corticopetal projection neurons have received particular attention due to their loss in Alzheimer's disease. In MRI images, the precise delineation of these structures is difficult due to limited spatial resolution and contrast. Here, using microscopic delineations in ten human postmortem brains, we present stereotaxic probabilistic maps of the basal forebrain areas containing the magnocellular cell groups. Cytoarchitectonic mapping was performed in silver stained histological serial sections. The positions and the extent of the magnocellular cell groups within the septum (Ch1-2), the horizontal limb of the diagonal band (Ch3), and in the sublenticular part of the basal forebrain (Ch4) were traced in high-resolution digitized histological sections, 3D reconstructed, and warped to the reference space of the MNI single subject brain. The superposition of the cytoarchitectonic maps in the MNI brain shows the intersubject variability of the various Ch compartments and their stereotaxic position relative to other brain structures. Both the right and left Ch4 regions showed significantly smaller volumes when age was considered as a covariate. Probabilistic maps of compartments of the basal forebrain magnocellular system are now available as an open source reference for correlation with fMRI, PET, and structural MRI data of the living human brain.

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Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease

Cited by 265 publications

References 46 publications

MEG resting state functional connectivity in Parkinson’s disease related dementia

MEG resting state functional connectivity in Parkinson’s disease related dementia

Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome

Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain

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