Cell‐mediated immune responses to artificial food additives in chronic urticaria

Warrington, Richard; Sauder, Patricia J.; McPhillips, Shawn

doi:10.1111/j.1365-2222.1986.tb01991.x

Cited by 17 publications

(8 citation statements)

References 20 publications

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“…All patients met the diagnostic criteria for AD as defined by Hanifin and Rajka [26]. It has been suggested that adverse reactions to food additives are non-IgE-mediated [19,20]; therefore, subjects with a normal range of serum total IgE levels (< 300 IU/ml) were selected [27]. …”

Section: Methodsmentioning

confidence: 99%

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Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis

et al. 2011

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The prevalence of atopic dermatitis (AD) in school-age children has increased in industrialized countries. As diet is one of the main factors provoking AD, some studies have suggested that food additives in processed foods could function as pseudoallergens, which comprise the non-immunoglobulin E-mediated reaction. Eosinophil cationic protein (ECP) is an eosinophil granule protein released during allergic reactions to food allergens in patients with AD. Thus, serum ECP levels may be a useful indicator of ongoing inflammatory processes in patients with AD. The purpose of this study was to investigate the effect of consuming MSG in processed foods on serum ECP levels among children with AD. This study was performed with 13 patients with AD (age, 7-11 years) who had a normal range of total IgE levels (< 300 IU/ml). All participants ate normal diets during the first week. Then, six patients were allocated to a processed food-restricted group (PRDG) and seven patients were in a general diet group (GDG). During the second week, children in the PRDG and their parents were asked to avoid eating all processed foods. On the third week, children in the PRDG were allowed all foods, as were the children in the GDG throughout the 3-week period. The subjects were asked to complete a dietary record during the trial period. Children with AD who received the dietary restriction showed decreased consumption of MSG and decreased serum ECP levels and an improved SCORing score on the atopic dermatitis index (P < 0.05). No differences in serum ECP levels or MSG consumption were observed in the GDG. Serum total IgE levels were not changed in either group. In conclusion, a reduction in MSG intake by restricting processed food consumption may lead to a decrease in serum ECP levels in children with AD and improve AD symptoms.

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Section: Methodsmentioning

confidence: 99%

“…This categorization has been extended by creating a third subgroup of mixed IgE- and non-IgE-mediated disorders such as AD, allergy asthma, and eosinophilic esophagitis [7,18]. Some studies have suggested a mechanism that associates non-IgE-mediated or delayed-in-time responses with food additives [9,19]. …”

Section: Introductionmentioning

confidence: 99%

Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis

et al. 2011

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“…Katkı maddelerine karşı gelişen allerjik reaksiyonlarda birincil aracı madde, mast hücrelerinden salınan histamindir [15,16] . Histaminin yanı sıra prostaglandinler, leukotrienler, bradikininler ve lökosit inhibitör faktörün de (LIF) katkı maddelerine karşı meydana gelen reaksiyonlarda payının olabileceğini gösteren çalış-malar bulunmaktadır [17][18][19] . Bu çalışma; sunset yellow'un allerjik reaksiyonlarda önemli rol oynayan mast hücrelerinin degranülasyonu üzerindeki etkisinin araştırılması ve söz konusu katkı maddesini içeren gıdaların özellikle alerjik bünyeli ve gebelik gibi hassas dönemlerdeki tüketiciler tarafından daha bilinçli kullanılması hususunda ön bilgiler sağlayacağı düşüncesi ile gerçekleştirilmiştir.…”

Section: Makale Kodu (Article Code): Kvfd-2013-8982unclassified

Sunset Yellow FCF’ nin Tavuk Embriyosu Deri ve Barsak Mast Hücrelerinin Degranülasyonu Üzerindeki Etkileri

Güler¹,

Koca²

2013

Kafkas Univ Vet Fak Derg

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Bu çalışmada, hazır gıdalarda yapay renklendirici olarak kullanılan sunset yellow'un (E110) tavuk embriyosu dermal ve mukozal mast hücrelerindeki degranülasyon etkisi histolojik yönden incelenmiştir. Sunset yellow (2.5 mg/kg) inkübasyonun 15. gününde vitellusa enjekte edilmiştir. Enjeksiyonundan 6, 12 ve 24 saat sonra dermal ve mukozal mast hücrelerindeki degranülasyon etkisi incelenmiştir. Dermal mast hücrelerinde (deri) en fazla kısmi degranülasyon sunset yellow enjeksiyondan 12 saat, mukozal mast hücrelerinde (barsak) 6 saat sonra, en fazla ileri düzeyde degranülasyon ise deride enjeksiyondan 24 saat, barsakta 12 saat sonra gözlenmiştir. Barsaktaki mukozal mast hücrelerinde ileri degranülasyonun enjeksiyondan 24 saat sonra da devam ettiği belirlenmiştir. Her iki dokuda kısmi degranüle mast hücresi granüllerinin gevşek ve kaba granüller oluşturduğu, ileri degranülasyon gösteren mast hücrelerinin ise daha az granül içerdiklerinden dolayı daha aydınlık sitoplazmaya sahip oldukları görülmüştür. Anahtar sözcükler: Sunset yellow, Tavuk embriyosu, Mast hücresi, Deri, Barsak Degranulation Effects of Sunset Yellow-FCF on Dermal and Intestinal Mast Cells of Chicken Embryo SummaryIn this study, the degranulation effect of sunset yellow (E110) which is used as artificial coloring agent in ready food was histologically examined on dermal and mucosal mast cells of chicken embryo. Sunset yellow (2.5 mg/kg) was injected into vitellus of eggs on the 15 th day of incubation. Degranulation of dermal and mucosal mast cells were evaluated 6, 12, 24 h after injection. The most of partial degranulated in dermal mast cells (skin) was observed after 12 h from injection of sunset yellow, and after 6 h in mucosal mast cells (intestine). High level degranulation in skin was showed after 24 h from injection, and after 12 h in intestine. Also, it was seen that high level degranulation in the mucosal mast cells of intestine were continued after 24 h from injection. In both types of tissues, it was found that partially degranulated mast cells formed loose and coarse granules while mast cells showing high level of degranulation have brighter cytoplasm since they contain less granuless.

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“…It has been reported that high doses of benzoic acid inhibit thromboxane B2 (TXB2) formation in neutrophils, whereas, at low concentrations, TXB2 formation is stimulated [14]. There is some evidence that individu als with chronic additive-induced urticaria responded to sodium benzoate with increased levels of the T cell cytokine leukocyte-inhibitory factor [15].…”

Section: Introductionmentioning

confidence: 99%

Release of Mediators from Human Gastric Mucosa and Blood in Adverse Reactions to Benzoate

Schaubschläger¹,

Becker²,

Schade³

et al. 1991

Int Arch Allergy Immunol

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A study was carried out on 29 patients to investigate the amount of histamine liberation and release of platelet-activating factor and 6-keto-prostaglandin F_1α from gastric mucosa and whole blood or mononuclear cells by sodium benzoate. The patients suffered from asthma (10), atopic dermatitis (7) and chronic urticaria (4). 8 patients with unrelated, non-immunologic diseases served as controls. In the oral provocation test (OPT) 3 patients experienced a recurrence of their original disease, whilst 1 asthmatic patient reacted with abdominal disorder. The release of histamine and prostaglandin from mucosa was significantly increased by sodium benzoate in comparison to the spontaneous release observed in patients. The mucosa of the control persons did not react to sodium benzoate. Furthermore, there was a significant difference in prostaglandin release between patients with positive OPT and the control persons. No difference could be found between patients with negative OPT and those with positive OPT. Additionally, in the mediator release from whole blood or mononuclear cells there was no obvious difference apparent. These results suggest a possible involvement of prostacyclin and histamine in adverse reactions to benzoate. Due to the sensitivity of the method, a mediator release from mucosa can already be demonstrated in a preclinical state of the pseudoallergic reaction in the absence of clinical symptoms.

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Cell‐mediated immune responses to artificial food additives in chronic urticaria

Cited by 17 publications

References 20 publications

Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis

Effect of processed foods on serum levels of eosinophil cationic protein among children with atopic dermatitis

Sunset Yellow FCF’ nin Tavuk Embriyosu Deri ve Barsak Mast Hücrelerinin Degranülasyonu Üzerindeki Etkileri

Release of Mediators from Human Gastric Mucosa and Blood in Adverse Reactions to Benzoate

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