1975
DOI: 10.1172/jci108021
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Cell-mediated immunity in acute and chronic hepatitis.

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Cited by 99 publications
(26 citation statements)
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References 27 publications
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“…We were not able to demonstrate significant inhibitory activity by sera from patients with CAH or AH on cytotoxicity by autologous lymphocytes in contrast to the findings of other investigators (6,10,19,21). As mentioned previously, antibodies to hepatic antigens present in autologous sera (39) may have blocked SCMC and promoted ADCC.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…We were not able to demonstrate significant inhibitory activity by sera from patients with CAH or AH on cytotoxicity by autologous lymphocytes in contrast to the findings of other investigators (6,10,19,21). As mentioned previously, antibodies to hepatic antigens present in autologous sera (39) may have blocked SCMC and promoted ADCC.…”
Section: Discussioncontrasting
confidence: 99%
“…Unlike several studies of lymphocyte cytotoxicity in CAC (8,17), we were able to demonstrate that lymphocytes from patients with CAC still manifest in vitro cytotoxic capability. The decreased in vitro cytotoxicity shown by patients with CAH on steroid therapy supports the findings of others (6,7,16,19,20), suggesting further that corticosteroids inhibit the effector phase of lymphocyte-mediated cytotoxicity (35). Several mechanisms have been suggested to account for in vitro cell-mediated cytotoxicity in CAH and AH.…”
Section: Discussionsupporting
confidence: 76%
“…The relatively greater sensitivity to the effects of irradiation of the net T cell helper signal (the balance between helper and suppressor signals) in the antigen-induced system, when compared with the PWM-induced system, is similar to the pattern reported in other in vitro antigen-induced antibody systems (15-17, 19, 36 The human immune response, including cellular immune reactivity to HBsAg, has been extensively evaluated by a variety of techniques, including migration inhibition, cytotoxicity assays, and blast transformation after infection with hepatitis B virus (reviewed, 9 and 10). In the convalescent phase after resolution of hepatitis B viral infection, blastogeneic responses to HBsAg have been reported by some (46-48) but not all authors (49). In the papers that report positive results, the stimulation index has been relatively low (usually .5).…”
Section: Resultsmentioning
confidence: 99%
“…The isolation of peripheral blood lymphocytes, the preparation and [51Cr]chromium labeling of Chang cells, lymphocyte blast transformation, and cytotoxicity studies were performed as previously described (19). RESULTS Characterization of m-Con A.…”
Section: Methodsmentioning
confidence: 99%