Cell Mediated Photothermal Therapy of Brain Tumors

Hirschberg, Henry; Madsen, Steen J.

doi:10.1007/s11481-016-9690-9

Cited by 35 publications

(23 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of laser wavelength in the ‘tissue optical window’ (700–1000 nm) minimizes tissue heating, while Au NPs have strong and tunable absorption in the NIR region. Therefore, Au NPs and NIR can be used to facilitate selective heating of tumours with NPs [ 127 ]. Gold nanoparticles with thiol and amine groups can be functionalized with targeted antibodies or drug products.…”

Section: Cancer Therapymentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

View full text Add to dashboard Cite

Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

show abstract

Section: Cancer Therapymentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

View full text Add to dashboard Cite

show abstract

“…For instance, Eldridge et al have demonstrated the sound efficacy of PTT against GBM by near-infrared (NIR) irradiation of multiwalled carbon nanotubes in an in vitro tumor spheroid model 23 . Due to their innate tumor-tropic migration behavior, macrophages loaded with Au nanoshells have also been adopted for NIR-induced thermal ablation of GBM 24 . A delayed growth of GBM in rats receiving the cell-based photothermal therapy was observed compared to the untreated group.…”

Section: Introductionmentioning

confidence: 99%

Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma

et al. 2018

View full text Add to dashboard Cite

Therapeutic efficacy of glioblastoma multiforme (GBM) is often severely limited by poor penetration of therapeutics through blood-brain barrier (BBB) into brain tissues and lack of tumor targeting. In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target brain tumor and convert deep tissue-penetrating near-infrared (NIR) light into visible light for precise phototherapies on brain tumor was developed in this work.Methods: The UCNP-based phototherapy delivery system was acquired by assembly of oleic acid-coated UCNPs with angiopep-2/cholesterol-conjugated poly(ethylene glycol) and the hydrophobic photosensitizers. The hybrid nanoparticles (ANG-IMNPs) were characterized by DLS, TEM, UV/vis and fluorescence spectrophotometer. Cellular uptake was examined by laser scanning confocal microscopy and flow cytometry. The PDT/PTT effect of ANG-IMNPs was evaluated using MTT assay. Tumor accumulation of NPs was determined by a non-invasive in vivo imaging system (IVIS). The in vivo anti-glioma effect of ANG-IMNPs was evaluated by immunohistochemical (IHC) examination of tumor tissues and Kaplan-Meier survival analysis.Results: In vitro data demonstrated enhanced uptake of ANG-IMNPs by murine astrocytoma cells (ALTS1C1) and pronounced cytotoxicity by combined NIR-triggered PDT and PTT. In consistence with the increased penetration of ANG-IMNPs through endothelial monolayer in vitro, the NPs have also shown significantly enhanced accumulation at brain tumor by IVIS. The IHC tissue examination confirmed prominent apoptotic and necrotic effects on tumor cells in mice receiving targeted dual photo-based therapies, which also led to enhanced median survival (24 days) as compared to the NP treatment without angiopep-2 (14 days).Conclusion: In vitro and in vivo data strongly indicate that the ANG-IMNPs were capable of selectively delivering dual photosensitizers to brain astrocytoma tumors for effective PDT/PTT in conjugation with a substantially improved median survival. The therapeutic efficacy of ANG-IMNPs demonstrated in this study suggests their potential in overcoming BBB and establishing an effective treatment against GBM.

show abstract

“…At a wavelength of 0.6 -1.4 µm and over, the skin, muscles and bones, parenchymal organs and highly vascularized tissue absorb 25-40%, 30-80%, and up to 100% of radiation, respectively [19]. IR laser radiation at the doses of 5 -40 J/cm 2 are often used for local laser hyperthermia of neoplasms inducing coagulative necrosis of the tumor with minimal damage to surrounding healthy tissues [20].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system

Долгова¹,

Абакумова²,

Генинг³

et al. 2019

Biomed. Opt. Express

View full text Add to dashboard Cite

Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm 2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

show abstract

Cell Mediated Photothermal Therapy of Brain Tumors

Cited by 35 publications

References 57 publications

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Targeted Delivery of Functionalized Upconversion Nanoparticles for Externally Triggered Photothermal/Photodynamic Therapies of Brain Glioblastoma

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system

Contact Info

Product

Resources

About