Cell Membrane Alteration as a Source of Primary Hypertension

Postnov, Yu. V.; Orlov, Sergei N.

doi:10.1097/00004872-198402000-00001

Cited by 101 publications

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“…7,11 The system of free and bound calcium (approximately 50% of total calcium is bound) represents a calcium buffer. Since plasma and intracellular concentrations were not significantly different in patients, our results suggest, that plasma and intracellular measurements alone may be not adequate in determining calcium metabolism in hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…2,[5][6][7][8][9][10] Additionally, animal data suggest disturbed membrane calcium handling in hypertensive rats. 11 Calcium influx across the external cellular membrane in smooth muscle cells and cardiomyocytes plays a crucial role in the control of cellular excitation, contraction and impulse propa- gation. Intracellular calcium concentrations are controlled by the reversible binding to specific calcium binding proteins.…”

Section: Introductionmentioning

confidence: 99%

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Increased membraneous calcium concentrations in primary hypertension: a causal link to pathogenesis?

et al. 2000

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Background: Disturbance in calcium metabolism has been suggested in the pathogenesis of hypertension, however, membrane calcium content in humans has not been studied in detail yet in primary hypertension. We compared plasma, intracellular and membrane calcium concentrations in erythrocytes of patients with essential hypertension and in healthy, normotensive control subjects to determine a possible alteration of membrane calcium in primary hypertension. Subjects and Methods: Thirty-four never treated patients with essential hypertension were included and 34 healthy, age-and sex-matched volunteers served as controls. Atomic absorption spectroscopy was used for measurement of intracellular and membrane calcium content in erythrocytes and plasmalemmal preparations. Results: Plasma and intracellular Ca ++ concentrations

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased membraneous calcium concentrations in primary hypertension: a causal link to pathogenesis?

et al. 2000

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“…By "membranopathy," we mean the presence of widespread (i.e., not limited to cardiovascular contractile elements) abnormalities in the ion transport function of the cell plasma membrane and changes in its ultrastructure as well as in certain physico-chemical properties, resulting in insufficient membrane control over intracellular calcium (the "membrane defect"). 1 The major pathogenetically significant consequence of these alterations is the appearance of increased concentrations of cytoplasmic free calcium under physiological action on the mechanisms of cell calcium homeostasis. At least three known membrane abnormalities should be considered as a source of this free calcium excess: increased calcium influx rate in various types of cells (which occurs in hypertension despite the difference in transport systems maintaining the calcium influx in different cells), the decrease of calcium binding by the inner surface of the plasma membrane, and the alteration of adenosine triphosphate (ATP)-dependent, calmodulinstimulated outward calcium transport (for review, see Reference 2).…”

Section: An Approach To the Explanation Of Cell Membrane Alteration Imentioning

confidence: 99%

An approach to the explanation of cell membrane alteration in primary hypertension.

Postnov¹

1990

Hypertension

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“…It has been suggested that cell membrane alterations are responsible for certain blood pressure disorders (10). The fluidity of the erythrocyte membrane is an important determinant that modulates their rheologic behavior and is a main feature defining blood viscosity (11); this property is related to hypertensive and atherosclerotic disease.…”

Section: Introductionmentioning

confidence: 99%

Vitex Agnus-Castus L. Essential Oil Increases Human Erythrocyte Membrane Fluidity

Ajdžanović¹,

Spasojević²,

Pantelic³

et al. 2012

Journal of Medical Biochemistry

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Summary: Erythrocyte membrane fluidity is related to their rheologic behavior, the dynamic quality of erythrocytes, which is tempted in hypertension and atherosclerosis. An increased risk of these and other cardiovascular diseases occurs in ageing women. Menopause-related conditions are often treated with hormone replacement therapy that may increase the risk of malignancies. Vitex agnus-castus L. essential oil contains various organic compounds (monoterpenes, sesquiterpenes and terpenoids), and is increasingly used as an alternative therapy for menopausal symptoms. These components of the oil may be incorporated into cell membranes, thereby changing the membrane fluidity. The aim of this study was to determine the effects of Vitex agnuscastus essential oil on human erythrocyte membrane fluidity at graded depths. We used Electron Paramagnetic Resonan ce spectroscopy and fatty acid spin probes (5-doxyl stearic acid and 12-doxyl stearic acid), whose spectra depend on membrane fluidity. After treatment with Vitex agnus-castus essential oil the erythrocytes had a significant (p=0.029) and reversible increase in membrane fluidity in the deeper hydrophobic membrane regions, with no change (p>0.05) in fluidity near the membrane's hydrophilic surface. These results document increased fluidity of the human erythrocyte membrane by Vitex agnus-castus essential oil, and this action may be useful in patients with menopause--related hypertension and other cardiovascular conditions. Keywords: erythrocytes, membrane fluidity, Vac essential oil, EPR Kratak sadr`aj: Fluidnost membrane eritrocita uslovljava njihove reolo{ke karakteristike, svojevrsne dinami~ke kva litete, izmenjene u hipertenziji i aterosklerozi. Rizik od navedenih i drugih kardiovaskularnih oboljenja se kod `ena po ve}ava sa sta renjem. Tegobe koje prate menopauzu se obi~no ubla`avaju supstitucionom hormonskom terapijom, koja mo`e pove}ati rizik od pojave malignih oboljenja. Esencijalno ulje biljke Vitex agnus-castus L. sadr`i razli~ita organska jedinjenja (monoterpene, seskviterpene i terpenoide) i svẽ e{}e se koristi kao alternativno terapijsko sredstvo za simptome me no pauze. Navedene komponente esencijalnog ulja mogu se ugraditi u }elijske membrane i menjati njihovu fluidnost. Cilj studije bio je da se utvrde efekti esencijalnog ulja biljke Vitex agnus-castus na fluidnost membrane eritrocita po njenoj du bini. Kori{}ena je spektroskopija elektronske paramagnetne rezonance i masnokiselinske spinske probe (5-dok sil stea rinska i 12-doksil stearinska kiselina), ~iji spektri za vise od fluidnosti membrane. Nakon tretmana eritrocita esencijal nim uljem biljke Vitex agnus-castus utvr|eno je zna~ajno (p=0,029) i reverzibilno pove}anje fluidnosti njihove membrane u dubljim, hidrofobnim regionima, dok u povr{inskim, hidrofilnim regionima eritrocitne membrane nisu utvr|ene zna~ajne promene (p>0,05). Ovi rezultati uka zuju na po ve}anje fluidnosti eritrocitne membrane nakon tretmana esencijalnim uljem biljke Vitex agnus-castus, {to mo`e biti ko ristan efekat pri tretm...

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Cell Membrane Alteration as a Source of Primary Hypertension

Cited by 101 publications

References 0 publications

Increased membraneous calcium concentrations in primary hypertension: a causal link to pathogenesis?

Increased membraneous calcium concentrations in primary hypertension: a causal link to pathogenesis?

An approach to the explanation of cell membrane alteration in primary hypertension.

Vitex Agnus-Castus L. Essential Oil Increases Human Erythrocyte Membrane Fluidity

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