Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Li, Jianzhuang; Wei, Yanhao; Zhang, Chunlin; Bi, Rentang; Qiu, Yue; Li, Yanan; Hu, Bo

doi:10.3390/pharmaceutics15020621

Cited by 33 publications

(14 citation statements)

References 150 publications

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“…Another challenge is the potential for off-target effects, as exosomes can be taken up by cells other than the intended target cells. 113 , 114 Furthermore, the heterogeneity of exosomes derived from different cell types can make it difficult to compare and interpret results from different studies.…”

Section: Cell-based Nanoparticle Drug Delivery Strategies For Overcom...mentioning

confidence: 99%

Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier

Lim,

Yee,

Khang

2024

IJN

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The blood-brain barrier (BBB) and blood-tumor barrier (BTB) pose substantial challenges to efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor prognosis. Nanoparticle-based combinational strategies have emerged as promising modalities to overcome these barriers and enhance drug penetration into the brain parenchyma. This review discusses various nanoparticle-based combinatorial approaches that combine nanoparticles with cell-based drug delivery, viral drug delivery, focused ultrasound, magnetic field, and intranasal drug delivery to enhance drug permeability across the BBB and BTB. Cell-based drug delivery involves using engineered cells as carriers for nanoparticles, taking advantage of their intrinsic migratory and homing capabilities to facilitate the transport of therapeutic payloads across BBB and BTB. Viral drug delivery uses engineered viral vectors to deliver therapeutic genes or payloads to specific cells within the GBM microenvironment. Focused ultrasound, coupled with microbubbles or nanoparticles, can temporarily disrupt the BBB to increase drug permeability. Magnetic field-guided drug delivery exploits magnetic nanoparticles to facilitate targeted drug delivery under an external magnetic field. Intranasal drug delivery offers a minimally invasive avenue to bypass the BBB and deliver therapeutic agents directly to the brain via olfactory and trigeminal pathways. By combining these strategies, synergistic effects can enhance drug delivery efficiency, improve therapeutic efficacy, and reduce off-target effects. Future research should focus on optimizing nanoparticle design, exploring new combination strategies, and advancing preclinical and clinical investigations to promote the translation of nanoparticle-based combination therapies for GBM.

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Section: Cell-based Nanoparticle Drug Delivery Strategies For Overcom...mentioning

confidence: 99%

Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier

Lim,

Yee,

Khang

2024

IJN

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“…For example, peptide- and antibody-based targeting strategies are currently used in oncotherapy to deliver drugs to tumor cells or tissues. 188 Synthesizing antibody-drug conjugates consist of the antibody, which targets an antigen exposed at the cell surface, chemically linked to the active therapeutic agent, known as the warhead. However, this approach is currently limited to highly potent drugs, given the large size of antibodies that gives a low loading efficiency.…”

Section: Piezo Channels As Therapeutic Targets?mentioning

confidence: 99%

PIEZO Ion Channels in Cardiovascular Functions and Diseases

Coste,

Delmas

2024

Circulation Research

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The cardiovascular system provides blood supply throughout the body and as such is perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with mechanosensory structures that respond and adapt to changes in mechanical stimuli. Since their discovery in 2010, PIEZO ion channels have dominated the field of mechanobiology. These have been proposed as the long-sought-after mechanosensitive excitatory channels involved in touch and proprioception in mammals. However, more and more pieces of evidence point to the importance of PIEZO channels in cardiovascular activities and disease development. PIEZO channel-related cardiac functions include transducing hemodynamic forces in endothelial and vascular cells, red blood cell homeostasis, platelet aggregation, and arterial blood pressure regulation, among others. PIEZO channels contribute to pathological conditions including cardiac hypertrophy and pulmonary hypertension and congenital syndromes such as generalized lymphatic dysplasia and xerocytosis. In this review, we highlight recent advances in understanding the role of PIEZO channels in cardiovascular functions and diseases. Achievements in this quickly expanding field should open a new road for efficient control of PIEZO-related diseases in cardiovascular functions.

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“…185,186 To capitalize on the ability of macrophages to access the brain, researchers have developed a novel approach using macrophage membrane-coated nanoparticles (MM-NPs). 187 These nanoparticles are enveloped by membranes derived from macrophages, effectively mimicking the surface properties of these immune cells. 188 Under conditions such as brain inflammation, chemokines like CCL19 or CCL20 play a pivotal role in recruiting immune cells, including macrophages, to the affected area.…”

Section: Viral Inspired Approachmentioning

confidence: 99%

“…Macrophage is a type of immune cell, possess the ability to migrate into the brain under specific circumstances, particularly during inflammatory processes. , To capitalize on the ability of macrophages to access the brain, researchers have developed a novel approach using macrophage membrane-coated nanoparticles (MM-NPs) . These nanoparticles are enveloped by membranes derived from macrophages, effectively mimicking the surface properties of these immune cells .…”

Section: Biomimetic Approaches For Cns Diseasesmentioning

confidence: 99%

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Kumar,

Karim,

Sweety

et al. 2023

ACS Appl. Bio Mater.

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Disorders of the central nervous system (CNS) which include a wide range of neurodegenerative and neurological conditions have become a serious global issue. The presence of CNS barriers poses a significant challenge to the progress of designing effective therapeutic delivery systems, limiting the effectiveness of drugs, genes, and other therapeutic agents. Natural nanocarriers present in biological systems have inspired researchers to design unique delivery systems through biomimicry. As natural resource derived delivery systems are more biocompatible, current research has been focused on the development of delivery systems inspired by bacteria, viruses, fungi, and mammalian cells. Despite their structural potential and extensive physiological function, making them an excellent choice for biomaterial engineering, the delivery of nucleic acids remains challenging due to their instability in biological systems. Similarly, the efficient delivery of genetic material within the tissues of interest remains a hurdle due to a lack of selectivity and targeting ability. Considering that gene therapies are the holy grail for intervention in diseases, including neurodegenerative disorders such as Alzheimer's disease, Parkinson's Disease, and Huntington's disease, this review centers around recent advances in bioinspired approaches to gene delivery for the prevention of CNS disorders.

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Cell-Membrane-Coated Nanoparticles for Targeted Drug Delivery to the Brain for the Treatment of Neurological Diseases

Cited by 33 publications

References 150 publications

Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier

Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier

PIEZO Ion Channels in Cardiovascular Functions and Diseases

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

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