Cell membrane nanomaterials composed of phospholipids and glycoproteins for drug delivery in inflammatory bowel disease: A review

Lei, Pengyu; Yu, Haiyang; Ma, Jiahui; Du, Jiao; Fang, Yimeng; Yang, Qinsi; Zhang, Kun; Luo, Li; Jin, Libo; Wu, Wei; Sun, Da

doi:10.1016/j.ijbiomac.2023.126000

Cited by 7 publications

(2 citation statements)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of UC encompasses various processes, including inflammation, compromised epithelial barrier integrity, and oxidative harm . In the early stages of UC, macrophages, dendritic cells, and other antigenic presenting cells initiate a series of proinflammatory and anti-inflammatory signals that cause immune cells to migrate to the site of inflammation, and these immune cells penetrate the mucosa . Deficiencies in the mucin barrier provoke possible immune dysregulation and consequent inflammation within the intestines .…”

Section: Introductionmentioning

confidence: 99%

“… 7 In the early stages of UC, macrophages, dendritic cells, and other antigenic presenting cells initiate a series of proinflammatory and anti-inflammatory signals that cause immune cells to migrate to the site of inflammation, and these immune cells penetrate the mucosa. 8 Deficiencies in the mucin barrier provoke possible immune dysregulation and consequent inflammation within the intestines. 9 Aberrant demise of intestinal epithelial cells (IECs) can escalate the inflammatory reaction and trigger injury to the intestinal mucosa.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Curcumin-Encapsulated Co-ZIF-8 for Ulcerative Colitis Therapy: ROS Scavenging and Macrophage Modulation Effects

Tao,

Yao,

Wang

et al. 2024

ACS Omega

View full text Add to dashboard Cite

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by the disruption of the intestinal epithelial barrier. This study described the synthesis and characterization of CCM-Co-ZIF-8, a novel composite material with enzymelike activities similar to catalase, peroxidase, and superoxide dismutase. CCM-Co-ZIF-8 demonstrated the ability to scavenge reactive oxygen species that play a critical role in UC pathogenesis. In vitro studies using lipopolysaccharide-induced RAW264.7 cells showed that CCM-Co-ZIF-8 exhibited anti-inflammatory activity by promoting the transition of macrophages from an M1 to an M2 phenotype. In vivo experiments using a mouse model of UC demonstrated that CCM-Co-ZIF-8 suppressed the expression of proinflammatory cytokines. These findings suggested that CCM-Co-ZIF-8 might hold promise as a therapeutic strategy for the treatment of UC.

show abstract

Section: Introductionmentioning

confidence: 99%