Cell migration is another player of the minute virus of mice infection

Garcin, Pierre; Panté, Nelly

doi:10.1016/j.virol.2014.08.001

Cited by 6 publications

(9 citation statements)

References 55 publications

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“…It has recently been shown that one of those factors is an enhanced virus uptake in cancer cells. Cell migration, which is typically associated with some aggressive cancer cells, promotes MVMp uptake [ 65 ]. Another finding establishing a correlation between MVMp uptake and cancer cells is the requirement of MVMp for galectin-3, a multifunctional protein implicated in cancer metastasis.…”

Section: Uptake Into Host Cellsmentioning

confidence: 99%

Protoparvovirus Cell Entry

Ros

Bayat

Wolfisberg

et al. 2017

Viruses

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The Protoparvovirus (PtPV) genus of the Parvoviridae family of viruses includes important animal pathogens and reference molecular models for the entire family. Some virus members of the PtPV genus have arisen as promising tools to treat tumoral processes, as they exhibit marked oncotropism and oncolytic activities while being nonpathogenic for humans. The PtPVs invade and replicate within the nucleus making extensive use of the transport, transcription and replication machineries of the host cells. In order to reach the nucleus, PtPVs need to cross over several intracellular barriers and traffic through different cell compartments, which limit their infection efficiency. In this review we summarize molecular interactions, capsid structural transitions and hijacking of cellular processes, by which the PtPVs enter and deliver their single-stranded DNA genome into the host cell nucleus. Understanding mechanisms that govern the complex PtPV entry will be instrumental in developing approaches to boost their anticancer therapeutic potential and improving their safety profile.

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Section: Uptake Into Host Cellsmentioning

confidence: 99%

Protoparvovirus Cell Entry

Ros

Bayat

Wolfisberg

et al. 2017

Viruses

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“…Here, we went one step further as we identified a 5-protein classifier (FAK, N-cadherin, E-cadherin, β-catenin, Snail) that predicts response to MVMp virotherapy in murine PDAC models. We speculate that MVMp hijacks the uptake and lysosomal/proteasomal degradation of expired focal-adhesion molecules that are generated following physical tension of stress fibers, during the very dynamic process of mesenchymal cell migration, as previously described 16 We also established an instructive role of this classifier in predicting MVMp lytic efficacy in patient-derived primary pancreatic tumor cells, albeit the "mesenchymal status" does not perfectly match the classical/basal-like molecular subtyping found in the literature 22 . Here, Slug expression seems not to be as important as in murine PDAC cells to predict MVMp efficacy.…”

Section: Discussionmentioning

confidence: 55%

“…The present study illustrates for the first time the high selectivity of MVMp oncolytic virus for a particular subtype of PDAC, a disease with no cure that highly resist to conventional therapies. MVMp was previously found to enter leading edge of migrating cells by endocytosis close to filopodial and focal adhesions areas, notably following induction of EMT 16 . Interestingly, two main molecular subtypes have been recently described in PDAC, including the classical/pancreatic progenitor subtype associated with a better prognosis, and the Basal-like/Squamous subtype associated with resistance to treatment and poorer clinical prognosis, including immune escape 20 .…”

Section: Discussionmentioning

confidence: 97%

“…; https://doi.org/10.1101/2023.04.11.536425 doi: bioRxiv preprint and galectin-3 15 in MVMp cell surface binding and entry. Remarkably, MVMp infection is promoted by epithelial-mesenchymal transition (EMT) 16 , a situation that closely resemble basal-like phenotype of PDAC tumors, as MVMp preferably enters leading edge of migrating cells by endocytosis close to filopodial and focal adhesions areas 16 . During this work, we asked whether PDAC cells with basal-like, mesenchymal phenotype might be target for MVMp infection.…”

Section: Introductionmentioning

confidence: 99%

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Minute virus of mice is oncolytic for pancreatic cancer cells with mesenchymal phenotype

Garcin

Lulka

Vienne

et al. 2023

Preprint

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Pancreatic cancer will soon become the second cause of death by cancer in Western countries. The main barrier to increase the survival of patients with this disease requires the development of novel and efficient therapeutic strategies, that better consider tumor biology. Oncolytic viruses are quickly moving toward the forefront of medicines for the management of cancer. Among them, the fibrotropic minute virus of mice prototype (MVMp) preferentially infects migrating and undifferentiated cells, that highly resemble poorly differentiated, basal-like, pancreatic tumors showing the worst clinical outcome. Thus, we hypothesized that MVMp may specifically target the most aggressive subtype of pancreatic cancer cells. We report here that MVMp specifically infects, replicates in and kills pancreatic cancer cells from murine and human origin with a mesenchymal, basal-like profile, while sparing cancer cells with an epithelial phenotype. In vivo, MVMp shows oncolytic activity in experimental tumors with mesenchymal phenotype only, and shows increased antitumoral efficacy in immune competent models. Collectively, we demonstrate herein for the first time that MVMp is specific and oncolytic for pancreatic tumors with mesenchymal, basal-like profile, paving the way for precision medicine opportunities for the management of the most aggressive and lethal form of this disease.

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“…The minute virus of mice is a small, non-enveloped, single-stranded DNA virus from the Parvoviridae family, known for its oncotropic properties, infecting and killing cancer cells [106]. A study examining Gal-3 and N-acetylglucosaminyltransferase V (Mgat5) in MVM infection found that both are crucial for efficient cell entry and infection, with cancer cells expressing higher levels of Gal-3 being more susceptible to MVM infection [107].…”

Section: Minute Virus Of Micementioning

confidence: 99%

The Pivotal Role of Galectin-3 in Viral Infection: A Multifaceted Player in Host–Pathogen Interactions

Stojanović

Milovanović

et al. 2023

IJMS

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Galectin-3 (Gal-3), a beta-galactoside-binding lectin, plays a pivotal role in various cellular processes, including immune responses, inflammation, and cancer progression. This comprehensive review aims to elucidate the multifaceted functions of Gal-3, starting with its crucial involvement in viral entry through facilitating viral attachment and catalyzing internalization. Furthermore, Gal-3 assumes significant roles in modulating immune responses, encompassing the activation and recruitment of immune cells, regulation of immune signaling pathways, and orchestration of cellular processes such as apoptosis and autophagy. The impact of Gal-3 extends to the viral life cycle, encompassing critical phases such as replication, assembly, and release. Notably, Gal-3 also contributes to viral pathogenesis, demonstrating involvement in tissue damage, inflammation, and viral persistence and latency elements. A detailed examination of specific viral diseases, including SARS-CoV-2, HIV, and influenza A, underscores the intricate role of Gal-3 in modulating immune responses and facilitating viral adherence and entry. Moreover, the potential of Gal-3 as a biomarker for disease severity, particularly in COVID-19, is considered. Gaining further insight into the mechanisms and roles of Gal-3 in these infections could pave the way for the development of innovative treatment and prevention options for a wide range of viral diseases.

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Cell migration is another player of the minute virus of mice infection

Cited by 6 publications

References 55 publications

Protoparvovirus Cell Entry

Protoparvovirus Cell Entry

Minute virus of mice is oncolytic for pancreatic cancer cells with mesenchymal phenotype

The Pivotal Role of Galectin-3 in Viral Infection: A Multifaceted Player in Host–Pathogen Interactions

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