Cell-penetrating corosolic acid liposome as a functional carrier for delivering chemotherapeutic drugs

Li, Xuqian; Widjaya, Andy Samuel; Liu, Jingxuan; Liu, Xiao; Long, Zhiguo; Jiang, Yanyan

doi:10.1016/j.actbio.2020.02.013

Cited by 28 publications

(11 citation statements)

References 45 publications

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“…Uses include treatment of coughing, documented as early as 1590 CE in the Chinese Encyclopedia of Botany and Medicines [Li Shi-Zhen, Ben Cao Gang Mu (14)] and recent commercial herbal syrups treating throat pain. Recent work showed that ursane-type triterpenes in loquat, that is, ursolic acid (UA) and corosolic acid (CA), are a major class of bioactive compounds with anti-inflammatory, antidiabetic, and anticancer activities (15)(16)(17). However, gene pathways encoding the biosynthesis of these bioactive triterpenes have not been identified and characterized in loquat.…”

mentioning

confidence: 99%

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

Lin

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Whole-genome duplication (WGD) plays important roles in plant evolution and function, yet little is known about how WGD underlies metabolic diversification of natural products that bear significant medicinal properties, especially in nonmodel trees. Here, we reveal how WGD laid the foundation for co-option and differentiation of medicinally important ursane triterpene pathway duplicates, generating distinct chemotypes between species and between developmental stages in the apple tribe. After generating chromosome-level assemblies of a widely cultivated loquat variety and Gillenia trifoliata, we define differentially evolved, duplicated gene pathways and date the WGD in the apple tribe at 13.5 to 27.1 Mya, much more recent than previously thought. We then functionally characterize contrasting metabolic pathways responsible for major triterpene biosynthesis in G. trifoliata and loquat, which pre- and postdate the Maleae WGD, respectively. Our work mechanistically details the metabolic diversity that arose post-WGD and provides insights into the genomic basis of medicinal properties of loquat, which has been used in both traditional and modern medicines.

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mentioning

confidence: 99%

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

Lin

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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“…Lipid nanoparticles include similar structures such as micelles, reverse micelles, emulsions, microemulsions, transferosomes, ethosomes liposomes, and solid lipid nanoparticles (SLN). These structured systems have been broadly used to release several active compounds, including chemotherapeutic drugs [ 103 ], antibiotics [ 104 ], and genetic material [ 105 , 106 ]; however, in the last years’ diverse studies have described that SLN present an improved capacity to reach the dermis [ 107 ]. Different lipidic systems have been used to deliver a plethora of compound to the dermis; in this work, we describe a few applications in which lipid nanoparticle has been utilized to deliver compound with pharmaceutical potential into the dermis.…”

Section: Dermis As a Target For Nanotechnology-based Treatmentsmentioning

confidence: 99%

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

et al. 2022

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Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.

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“…First, it has no toxicity, immunogenicity, and so on because of its unique composition; second, when it degrades in vivo, there are no metabolic disorder, showing good biocompatibility; finally, liposomes can enhance the therapeutic effect of drugs and reduce their toxic and side effects. , Polymer-stabilized liposomes have become the dominant method . Polymers (usually polyethylene glycol) can be covalently attached to the headgroup of the lipid or physically adsorbed to the outer surface of the liposome to repel serum proteins or regulate drug release. , Polymers can also be designed as cages to protect the environment by cross-linking monomers preinserted into the lipid bilayer . Drug delivery systems with active targeting properties have been shown to have significant benefits in improving the therapeutic efficacy of glioma treatment .…”

Section: Introductionmentioning

confidence: 99%

“…23,24 Polymers can also be designed as cages to protect the environment by cross-linking monomers preinserted into the lipid bilayer. 25 Drug delivery systems with active targeting properties have been shown to have significant benefits in improving the therapeutic efficacy of glioma treatment. 26 The modification with target ligands, such as small molecules, antibodies, peptides, and antibody fragments, has been reported to significantly enhance the antitumor ability of drug-loaded delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Loaded Liposome with the Function of “Killing Two Birds with One Stone” against Glioma

Cen,

Dai,

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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The blood–brain barrier (BBB) continues to be one of the main clinical obstacles in the treatment of glioma. Current chemotherapies always bring many different side effects, some even permanent. To date, nanomaterial-based vehicles have shown great potential in treating glioma. Herein, we developed a dual targeting liposomal delivery vector loaded with the anticancer drug doxorubicin (DOX) to treat glioma. SS31, a small peptide, has shown dual targeting effects of penetrating the BBB and specifically targeting mitochondria. In this study, a new liposomal delivery system, LS-DOX, was prepared by modifying DOX-loaded liposomes with SS31 for the treatment of in situ glioma. The liposomes demonstrated a high drug encapsulation rate and drug-loading capacity, satisfactory biocompatibility, high glioma accumulation ability, and good stability in vitro. Experimental results showed that the liposomes could effectively cross the BBB and target gliomas, and mitochondria-targeting of SS31 enhances cell uptake. In addition, the liposomes showed a good therapeutic effect on nude mice with glioma in situ with no obvious toxicity and side effects. Therefore, the present research will provide a novel alternative and reference for the effective treatment of glioma.

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Cell-penetrating corosolic acid liposome as a functional carrier for delivering chemotherapeutic drugs

Cited by 28 publications

References 45 publications

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

Doxorubicin-Loaded Liposome with the Function of “Killing Two Birds with One Stone” against Glioma

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