Cell Penetrating Peptides: Biomedical/Therapeutic Applications with Emphasis as Promising Futuristic Hope for Treating Cancer

Khandia, Rekha; Munjal, Ashok; Kumar, Arvind; Singh, Gaurav; Karthik, Kumaragurubaran; Dhama, Kuldeep

doi:10.3923/ijp.2017.677.689

Cited by 10 publications

(6 citation statements)

References 74 publications

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“…Branched peptides have been explored in recent years for the isolation of compounds capable of nucleic acid condensation [1,2] and gene delivery [3][4][5], characterized by a high resistance to peptidases [6,7] or with application in multivalent interactions with biomolecular targets [8,9]. In the last decade, branched peptides and more in general oligopeptides covalently mounted on a molecular scaffold were explored for their metal-binding properties [10].…”

Section: Introductionmentioning

confidence: 99%

Cu(II) coordination to His-containing linear peptides and related branched ones: Equalities and diversities

Perinelli

Guerrini

Albanese

et al. 2020

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

Cu(II) coordination to His-containing linear peptides and related branched ones: Equalities and diversities

Perinelli

Guerrini

Albanese

et al. 2020

Journal of Inorganic Biochemistry

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“…The interaction is followed by CPPs or CPP/cargoes entrance via pore formation or membrane destabilization (Guidotti et al, 2017). According to the different transduced mechanisms, direct translocation is mainly divided into three models: "Barrel-Stave" model (Munjal et al, 2017), "Carpet-like" model (Guidotti et al, 2017) and Invertedmicelle model (Islam et al, 2018), which were presented in Figure 2.…”

Section: Direct Translocationmentioning

confidence: 99%

“…Building on the work of ACPP, Miampamba et al have designed and developed a novel intravenously administered AVB-620 by changing a ratiometric fluorescence readout from FRET using Cy5 and Cy7 as the couple fluorophores (Miampamba et al, 2017). AVB-620 was a fluorescent imaging agent for breast cancer diagnosis (Munjal et al, 2017). The experimental results indicated that AVB-620 can visualize the tumors under a fluorescence imaging camera system, which possesses high sensitivity and specificity in the diagnosis of lymph node status in metastatic murine breast cancer models, thus provide an excellent basis for clinical application (Miampamba et al, 2017).…”

Section: Cpps-mediated Molecular Probes As Imaging Agents For Diagnosismentioning

confidence: 99%

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

et al. 2020

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Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have been predominantly used in basic and preclinical research during the last 30 years. Since they are not only capable of translocating themselves into cells but also facilitate drug or CPP/cargo complexes to translocate across the plasma membrane, they have potential applications in the disease diagnosis and therapy, including cancer, inflammation, central nervous system disorders, otologic and ocular disorders, and diabetes. However, no CPPs or CPP/cargo complexes have been approved by the US Food and Drug Administration (FDA). Many issues should be addressed before translating CPPs into clinics. In this review, we summarize recent developments and innovations in preclinical studies and clinical trials based on using CPP for improved delivery, which have revealed that CPPs or CPP-based delivery systems present outstanding diagnostic therapeutic delivery potential.

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“… 70 The micelles then reach the cytosol and are destabilized because of the change of environment leading to release of the CPPs and the cargo they were loaded with. Despite the lack of hydrophobic residues in their structures, also CPPs such as TAT peptide and octaarginine can follow this mechanism of internalization 71 …”

Section: Cell‐penetrating Peptidesmentioning

confidence: 99%

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

Lāce

Cotroneo

Hesselbarth

et al. 2022

Journal of Peptide Science

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Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure, and morphology plays an important role in modulating physiological processes, such as transport of molecules, cell migration, or signaling, but it can also lead to lethal effects. The three main classes of membrane‐active peptides that are responsible for inducing such alterations are cell‐penetrating peptides (CPPs), antimicrobial peptides (AMPs), and fusion peptides (FPs). These peptides are able to interact with lipid bilayers in highly specific and tightly regulated manners. They can either penetrate the membrane, inducing nondestructive, transient alterations, or disrupt, permeabilize, or translocate through it, or induce membrane fusion by generating attractive forces between two bilayers. Because of these properties, membrane‐active peptides have attracted the attention of the pharmaceutical industry, and naturally occurring bioactive structures have been used as a platform for synthetic modification and the development of artificial analogs with optimized therapeutic properties to transport biologically active cargos or serve as novel antimicrobial agents. In this review, we focus on synthetic membrane interacting peptides with bioactivity comparable with their natural counterparts and describe their mechanism of action.

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Cell Penetrating Peptides: Biomedical/Therapeutic Applications with Emphasis as Promising Futuristic Hope for Treating Cancer

Cited by 10 publications

References 74 publications

Cu(II) coordination to His-containing linear peptides and related branched ones: Equalities and diversities

Cu(II) coordination to His-containing linear peptides and related branched ones: Equalities and diversities

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

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