2011
DOI: 10.1534/genetics.111.128231
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Cell Polarity in Saccharomyces cerevisiae Depends on Proper Localization of the Bud9 Landmark Protein by the EKC/KEOPS Complex

Abstract: In diploid Saccharomyces cerevisiae cells, bud-site selection is determined by two cortical landmarks, Bud8p and Bud9p, at the distal and proximal poles, respectively. Their localizations depend on the multigenerational proteins Rax1p/Rax2p. Many genes involved in bud-site selection were identified previously by genome-wide screening of deletion mutants, which identified BUD32 that causes a random budding in diploid cells. Bud32p is an atypical kinase involved in a signaling cascade of Sch9p kinase, the yeast … Show more

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Cited by 8 publications
(8 citation statements)
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“…Pcc1, Gon7, Kae1 and Bud32, for example, are recruited to several genomic loci and affect gene transcription [65]. Kae1 contributes to faithful chromosome segregation [64] while Bud32, Cgi121, Gon7 regulate cell polarity in bud-site selection [78]. Additionally, Bud32, Kae1 and Pcc1 are essential for a universal tRNA modification called threonyl carbamoyl adenosine (t6A), for which Cgi121 is dispensable [66].…”
Section: Discussionmentioning
confidence: 99%
“…Pcc1, Gon7, Kae1 and Bud32, for example, are recruited to several genomic loci and affect gene transcription [65]. Kae1 contributes to faithful chromosome segregation [64] while Bud32, Cgi121, Gon7 regulate cell polarity in bud-site selection [78]. Additionally, Bud32, Kae1 and Pcc1 are essential for a universal tRNA modification called threonyl carbamoyl adenosine (t6A), for which Cgi121 is dispensable [66].…”
Section: Discussionmentioning
confidence: 99%
“…Another hint in this puzzle is the fact that mutants of EKC/KEOPS complex components in yeast have random budding patterns 15 , 22 . This could also contribute with the EKC/KEOPS mutant slow-growth phenotype.…”
Section: Bud32/prpk Is Part Of the Ancient Ekc/keops Complexmentioning
confidence: 99%
“…KEOPS/EKC complex has been implicated in telomeres maintenance, 13 transcriptional regulation, 14 budding site selection 15 and chemical modification of tRNAs (tRNAs). 16 , 17 The core constituents of the KEOPS complex are present in Drosophila , but their physical interactions have not been reported yet.…”
Section: Bud32/prpk Is Part Of the Ancient Ekc/keops Complexmentioning
confidence: 99%
“…Bud3 and Bud4 are important for establishing axial budding pattern by recruiting Axl1 and Axl2. The third group contains Bud7, Bud8, Bud9, Rax1, and Rax2 that are specific for the bipolar pattern (Zahner et al 1996;Kato et al 2011). Bud8 marks the distal pole while Bud9 marks the proximal pole (Zahner et al 1996;Schenkman et al 2002).…”
Section: Division-site Selection and Actomyosin Contractile-ring Assementioning
confidence: 99%