Cell Polarity in Morphogenesis—Planar Cell Polarity

Mandrekar, Noopur; Su, Baihao; Habas, Raymond

doi:10.1016/b978-0-12-802438-6.00004-8

Cited by 3 publications

(3 citation statements)

References 89 publications

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Section: Resultsmentioning

confidence: 99%

“…Around 7% of identified MSC-EV proteins are related to GO_CC category 'melanosome'; melanosomes may share common features with exosomes due to the same endosomal origin. Finally, about 5% of identified MSC-EV proteins are related to GO_CC category 'lamellipodium', belonging to branched actin filaments that provide force for plasma membrane protrusion during cell migration, which is promoted by the actin-nucleating Arp2/3 complex [69]; perhaps cytoskeletal structures within EV could help to maintain the shape of the vesicle, but also could deliver a 'builder' (Arp2/3) to raise cell scaffolds. Among the top enriched GO_BP categories were those associated with cell adhesion (around 11% of identified proteins), extracellular matrix organization (5%), ribosomes (7%), and cell movement (4%) (with Arp2/3 as one of the major players), which overlap with the top GO_CC categories mentioned above.…”

Section: Proteomic Analysismentioning

confidence: 99%

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Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

Turovsky¹,

Golovicheva²,

Varlamova³

et al. 2022

Int. J. Biol. Sci.

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Mesenchymal stromal cells (MSC) are widely recognized as potential effectors in neuroprotective therapy. The protective properties of MSC were considered to be associated with the secretion of extracellular vesicles (MSC-EV). We explored the effects of MSC-EV in vivo on models of traumatic and hypoxia-ischemia (HI) brain injury. Neuroprotective mechanisms triggered by MSC-EV were also studied in vitro using a primary neuroglial culture. Intranasal administration of MSC-EV reduced the volume of traumatic brain damage, correlating with a recovery of sensorimotor functions. Neonatal HI-induced brain damage was mitigated by the MSC-EV administration. This therapy also promoted the recovery of sensorimotor functions, implying enhanced neuroplasticity, and MSC-EV-induced growth of neurites in vitro supports this. In the in vitro ischemic model, MSC-EV prevented cell calcium (Ca 2+ ) overload and subsequent cell death. In mixed neuroglial culture, MSC-EV induced inositol trisphosphate (IP3) receptor-related Ca 2+ oscillations in astrocytes were associated with resistance to calcium overload not only in astrocytes but also in co-cultured neurons, demonstrating intercellular positive crosstalk between neural cells. This implies that phosphatidylinositol 3-Kinase/AKT signaling is one of the main pathways in MSC-EV-mediated protection of neural cells exposed to ischemic challenge. Components of this pathway were identified among the most enriched categories in the MSC-EV proteome.

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Section: Resultsmentioning

confidence: 99%

Section: Proteomic Analysismentioning

confidence: 99%

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

Turovsky¹,

Golovicheva²,

Varlamova³

et al. 2022

Int. J. Biol. Sci.

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“…In the case of the PCP pathway, Wnt ligands interact with FZD receptors that induce the expression of Rho‐ GTPases like Ras homolog gene family member A (RhoA), Ras‐related C3 botulinum toxin substrate (Rac) and cell division control protein 42 (Cdc42) (Martin‐Orozco et al, 2019). These GTPases regulate the cells shape and cytoskeleton by anchoring the proteins with the plasma membrane (Mandrekar et al, 2017). Thereby, canonical Wnt signaling regulates NC cell proliferation, whereas noncanonical Wnt signaling maintains NC cell polarity.…”

Section: Wnt Signaling and The Nc Cellsmentioning

confidence: 99%

Neural crest cells development and neuroblastoma progression: Role of Wnt signaling

Ahmad

Ghosh

Rizvi

et al. 2022

Journal Cellular Physiology

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Neuroblastoma (NB) is one of the most common heterogeneous extracranial cancers in infancy that arises from neural crest (NC) cells of the sympathetic nervous system. The Wnt signaling pathway, both canonical and noncanonical pathway, is a highly conserved signaling pathway that regulates the development and differentiation of the NC cells during embryogenesis. Reports suggest that aberrant activation of Wnt ligands/receptors in Wnt signaling pathways promote progression and relapse of NB. Wnt signaling pathways regulate NC induction and migration in a similar manner; it regulates proliferation and metastasis of NB. Inhibiting the Wnt signaling pathway or its ligands/receptors induces apoptosis and abrogates proliferation and tumorigenicity in all major types of NB cells. Here, we comprehensively discuss the Wnt signaling pathway and its mechanisms in regulating the development of NC and NB pathogenesis. This review highlights the implications of aberrant Wnt signaling in the context of etiology, progression, and relapse of NB. We have also described emerging strategies for Wnt‐based therapies against the progression of NB that will provide new insights into the development of Wnt‐based therapeutic strategies for NB.

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Preface: Defining Polarity

Frankel

2018

Cell Polarity in Development and Disease

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Cell Polarity in Morphogenesis—Planar Cell Polarity

Cited by 3 publications

References 89 publications

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

Neural crest cells development and neuroblastoma progression: Role of Wnt signaling

Preface: Defining Polarity

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