Cell Population Kinetics of Transplanted and Metastatic Lewis Lung Carcinoma

Simpson-Herren, Linda; Sanford, Arthur; Holmquist, Jan

doi:10.1111/j.1365-2184.1974.tb00417.x

Cited by 39 publications

(17 citation statements)

References 6 publications

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“…In addition, however, the thymidine index of the primary tumours was also increased. (Schatten, 1958, Romsdahl, 1964, Riggins and Ketcham, 1965Rudenstam, 1968;Simpson-Herren et al, 1974). Prostatectomy for benign disease is a misnomer (Schwartz et al, 1986 (Denton et al, 1965;Coplen et al, 1991 (McNeal 1993).…”

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confidence: 99%

Proliferative response of human prostate tumour xenografts to surgical trauma and the transurethral resection of the prostate controversy

Bogden¹,

LePage²,

Zwicker³

et al. 1996

Br J Cancer

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Summary Transurethral resection of the prostate (TURP) as an excisional procedure involving multiple incisions into the prostate does not differentiate between palpably benign prostate tissue and microscopic foci of well-differentiated adenocarcinoma. The impact of TURP on the progression of such 'latent' or 'incidental' tumours unique to the prostate gland has been a focal point of a continuing controversy. In studies designed to develop preclinical evidence that would lend support to, or detract from, either side of the TURP controversy, surgical trauma-induced stimulation of in situ tumour growth was extended to include human prostate tumour tissue PC-3, DU-145 and H-1579, albeit (Coplen et al., 1991). An astonishingly high prevalence of what pathologists have interpreted as microscopic foci of well-differentiated adenocarcinoma has been found at autopsy in serial sections of prostate glands considered to be normal from men over the age of 50. Every decade of ageing nearly doubles the incidence of such tumours -from 10% in men in their 50s to 70% in men in their 80s (Scott et al., 1969;Sheldon et al., 1980). Such a prevalence of 'latent' or 'incidental' tumours appears to be unique to the prostate gland (Silverberg and Lubera, 1989). The biological potential of focal low-grade, incidentally discovered prostatic cancer (stage Al) has generally been believed to be relatively innocuous, although this view has been challenged in recent years by several groups who have found a 16-27% rate of disease progression in patients followed for extended periods (Blute et al., 1986;Epstein et al., 1986). The phenomenon of tumour cell dissemination by surgical manipulation has been investigated with various surgical procedures and tumour types and is hardly a fresh topic. It has, however, become an important concept for exploration with regard to prostatic carcinoma, considering both the incidence of this particular tumour and the frequency with which TURP has been performed for obstructive symptoms. The actual impact of TURP on the development of metastases, however, is not well defined. McGowan (1980) has reported that the 5 year actuarial disease-free survival of patients with clinical stage B and C tumours treated by radiation therapy is significantly lower for patients who have undergone prior TURP compared with patients who have not undergone prior TURP. Further, it has been speculated that the relatively poor prognosis of patients with stage A2 prostatic tumours may be related to tumour dissemination during TURP (Walsh, 1980 al., 1983) or to the possibility that the patients who were selected for TURP had a higher incidence of clinically occult metastases before the procedure bears upon the influences of the method of diagnosis (TURP vs needle biopsy) on patient outcome, which is also controversial (Hanks et al., 1986;Kuban et al., 1987;McGowan, 1988).In a retrospective analysis of 225 patients with localised adenocarcinoma of the prostate who were treated with continuous-course external-beam radiation therapy, A...

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Proliferative response of human prostate tumour xenografts to surgical trauma and the transurethral resection of the prostate controversy

Bogden¹,

LePage²,

Zwicker³

et al. 1996

Br J Cancer

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“…A similar activity was subsequently described by Gordon et al (1975) in extracts from human malignant tissues and from an experimental tumour (rabbit Xr2 carcinoma) but not in extracts from normal tissues. This activity appeared to be related to the presence in the extracts of a serum protease called Cancer Procoagulant A (CPA; Gordon et al, 1975 al., 1965al., : Frindel et al, 1967Simpson-Herren et al. 1974: Poggi et al, 1977.…”

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Evidence that cells from experimental tumours can activate coagulation factor X

Curatolo¹,

Colucci²,

Cambini³

et al. 1979

Br J Cancer

100

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Summary.-The procoagulant activity of cells from some experimental tumours isolated in culture or in single-cell suspensions from ascitic fluid was investigated. Cells from Lewis lung carcinoma (primary and metastasis), Ehrlich carcinoma ascites and JW sarcoma ascites were able to shorten markedly the recalcification time of normal, Factor VIII-and Factor VII-deficient but not of Factor X-deficient human plasma. The same cells generated thrombin when mixed with a source of prothrombin and Factor X, absorbed bovine serum (as a source of Factor V), phospholipid and calcium chloride. Thrombin formation was not influenced by the presence of Factor VII. Cells from Sarcoma 180 ascites were completely inactive in both test systems. It is concluded that cells from some experimental tumours have the capacity to activate Coagulation Factor X directly. These findings suggest the existence of an alternative "cellular" pathway in the initiation of blood clotting distinct from both the intrinsic and extrinsic mechanisms.

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“…Lewis lung carcinoma, which originated spontaneously as a carcinoma of the lung of a C57/BL mouse at the Wistar Institute in 1951 (Sugiura and Stock, 1955) was implanted s.c. as a 0-1-ml homogenate in the lower flank. It is a rapidly growing epidermoid carcinoma which, when implanted s.c., metastasizes to the lung (Simpson-Herren, Sanford and Holmquist, 1974). Cells are released from the primary tumour 6 days after implantation (James and Salsbury, 1974).…”

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confidence: 99%

“…There was no significant differences between mice receiving NRS or ALS. The antimetastatic action of C. parvum was investigated using the Lewis lung carcinoma, a tumour which when grown s.c. metastasizes naturally to the lungs (Simpson-Herren et al, 1974). Reported experiments using primary tumour have indicated that T cell involvement in the anti-tumour response to C. parvum depends upon the route of injection of this vaccine (Woodruff et al, 1973;Scott, 1974;Woodruff and Dunbar, 1975).…”

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confidence: 99%