Cell Proliferation and Chemical Carcinogenesis: summary and future directions

Swenberg, James A.

doi:10.1289/ehp.93101s5153

Cited by 14 publications

(6 citation statements)

References 9 publications

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“…30 Proliferation probably increases the risk of mutations within target cells, and may also be important in selective clonal expansion of (exogenously or endogenously) initiated cells from pre-neoplastic foci and eventually tumours. 31 Further research will be required to fully elucidate this relationship.…”

Section: Discussionmentioning

confidence: 99%

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Carlin

Artioli²,

Matsumoto³

et al. 2010

Dentomaxillofacial Radiology

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Objectives: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from adults following cone beam CT exposure. Methods: A total of 19 healthy adults (10 men and 9 women) submitted to cone beam CT were included. Results: No significant statistically differences (P . 0.05) in micronucleus frequency were seen before and after cone beam CT exposure. In contrast, the tomography was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis and karyolysis (P , 0.05). Conclusion: In summary, these data indicate that cone beam CT may not be a factor that induces chromosomal damage, but it is able to promote cytotoxicity.

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Section: Discussionmentioning

confidence: 99%

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Carlin

Artioli²,

Matsumoto³

et al. 2010

Dentomaxillofacial Radiology

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“…22 In fact, a correlation between cell proliferation and induction of cancer is assumed. 23 It is likely that proliferation increases the risk of mutations within target cells, and is important in selective clonal expansion of (exogenously or endogenously) initiated cells from preneoplastic foci and eventually tumours. 22 In human cytogenetic studies some confounding factors need to be considered.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs

Angelieri

Carlin²,

Saez³

et al. 2010

Dentomaxillofacial Radiology

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Objectives: The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography. Methods: Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days. Results: The results revealed no statistically significant difference (P . 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis. Conclusions: Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity.

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“…33 In fact, a correlation between cell proliferation and induction of cancer is assumed. 34 It is likely that proliferation increases the risk of mutations within target cells and may also be important in selective clonal expansion of exogenously or endogenously initiated cells from preneoplastic foci and eventually tumors. 33 On the basis of the current understanding that smoking exerts a negative infl uence on the oral mucosa, it was hypothesized that buccal cells would also be affected by smoking.…”

Section: Ever-smokers Nonsmokersmentioning

confidence: 99%

Cytogenetic biomonitoring of oral mucosa cells from adults exposed to dental X-rays

Ribeiro

Angelieri

2008

Radiat Med

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Cell Proliferation and Chemical Carcinogenesis: summary and future directions

Cited by 14 publications

References 9 publications

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Biomonitoring of DNA damage and cytotoxicity in individuals exposed to cone beam computed tomography

Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs

Cytogenetic biomonitoring of oral mucosa cells from adults exposed to dental X-rays

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