Cell proliferation, apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment

Bottone, Maria Grazia; Soldani, Cristiana; Veneroni, Paola; Avella, Debora; Pisu, Maria Bonaria; Bernocchi, Graziella

doi:10.1111/j.1365-2184.2008.00530.x

Cited by 37 publications

(30 citation statements)

References 66 publications

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“…It is possible that variation in the endogenous balance between actin monomers and polymers may modulate the signaling to apoptosis, with alterations to actin providing the sensory mechanism [37]. Previous results by our group [3,38,39] demonstrate that different apoptogenic stimuli that do not directly affect the actin status are able to induce similar reorganization of the microfilament cytoskeleton, suggesting that these structural rearrangements may be viewed as an early morphological sign of apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Morphological Features of Organelles during Apoptosis: An Overview

Bottone

Santin

Aredia

et al. 2013

Cells

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An apoptotic program leading to controlled cell dismantling implies perturbations of nuclear dynamics, as well as changes affecting the organelle structure and distribution. In human cancer cells driven to apoptosis by different stimuli, we have recently investigated the morphological properties of several organelles, including mitochondria, lysosomes, endoplasmic reticulum and Golgi apparatus. In this review, we will discuss the body of evidence in the literature suggesting that organelles are generally relocated and/or degraded during apoptosis, irrespectively of the apoptogenic stimulus and cell type.

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Section: Resultsmentioning

confidence: 99%

Morphological Features of Organelles during Apoptosis: An Overview

Bottone

Santin

Aredia

et al. 2013

Cells

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“…Apoptosis of primary sensory dorsal root ganglion (DRG) neurons due to formation of platinum adducts in nuclear and mitochondrial DNA is a central mechanism in rodent models [11-19]. This results in mitochondrial dysfunction and disruption in cell cycle [14, 15, 19]. Thus the mechanisms of neurotoxicity and cancer cytotoxicity have many similarities and separating the beneficial cytotoxic effect from the neurotoxic effect may be difficult.…”

Section: Introductionmentioning

confidence: 99%

Candidate pathway-based genetic association study of platinum and platinum–taxane related toxicity in a cohort of primary lung cancer patients

Johnson

Pankratz

Velazquez

et al. 2015

Journal of the Neurological Sciences

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Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity secondary to chemotherapy. Genetic factors may be important in predisposing patients to this adverse effect. Patients and Methods We studied 950 primary lung cancer patients, who received platinum or platinum-combination drug chemotherapy and who had DNA available for study. We analyzed epidemiological risk factors in 279 CIPN patients and 456 non-CIPN patients and genetic risk factors in 141 CIPN patients and 259 non-CIPN patients. The risk factors studied included demographic, diagnostic, and treatment data, as well as 174 tag SNPs (single nucleotide polymorphisms) across 43 candidate genes in the glutathione, cell cycle, DNA repair, cell signaling, and apoptosis pathways. Results Patients who had diabetes mellitus were more likely to have CIPN (p=0.0002). Other epidemiologic risk factors associated with CIPN included number of cycles (p=0.0004) and type of concurrent chemotherapy (p<0.001) . SNPs most associated with CIPN were in glutathione peroxidase 7 (GPX7) gene (p values 0.0015 and 0.0028, unadjusted and adjusted) and in ATP-binding cassette sub-family C member 4 (ABCC4) gene (p values 0.037 and 0.006, unadjusted and adjusted). We also found other suggestive associations in methyl-o-guanine-methyl-transferase (MGMT) and glutathione-S-transferase (GST) isoforms. Conclusions Epidemiological and genetic risk factors associated with CIPN in this cohort, included the type of chemotherapy drug, intensity of chemotherapy treatment, and genes known to be associated with chemotherapy resistance. These findings suggest that differentiating between cytotoxic and neurotoxic mechanisms of chemotherapy drugs is challenging but represents an important step toward individualized therapy and improving quality of life for patients.

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“…1 Its serious adverse effects, especially nephrotoxicity, limit high-dose therapy with CP. CP induces renal tubular dysfunction and leads to acute renal injury (AKI) in a large proportion of patients.…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-3-gallate protects against cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis

Chen

Zou

et al. 2015

Exp Biol Med (Maywood)

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Cisplatin (CP)-induced nephrotoxicity hampers its application in clinic. Green tea, particularly its predominant polyphenolic constituent epigallocatechin-3-gallate (EGCG), possesses anti-inflammatory, antioxidant, and anti-apoptotic properties. The present study was designed to investigate the protective effects of EGCG against CP-induced nephrotoxicity in mice. Male C57/BL6 mice in different groups received single injection of CP (20 mg/kg) and EGCG (100 mg/kg) in various sets and kidney tissues and blood were collected after killing. Then, samples were used for biochemical and immunohistochemical assay. Our results showed EGCG decreased biochemical factors and immunohistochemical damage induced by CP. Besides, expression of phosphorylatedextracellular signal-regulated kinase (p-ERK), glucose-regulated protein 78 (GRP78), caspase-12, and apoptosis of kidney were decreased by EGCG via inhibition of endoplasmic reticulum (ER) stress-induced apoptosis.

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Cell proliferation, apoptosis and mitochondrial damage in rat B50 neuronal cells after cisplatin treatment

Abstract: CisPt exerts cytotoxic effects in the neuronal B50 cell line via a caspase-dependent pathway with mitochondria being central relay stations.

Cited by 37 publications

References 66 publications

Morphological Features of Organelles during Apoptosis: An Overview

Morphological Features of Organelles during Apoptosis: An Overview

Candidate pathway-based genetic association study of platinum and platinum–taxane related toxicity in a cohort of primary lung cancer patients

Epigallocatechin-3-gallate protects against cisplatin-induced nephrotoxicity by inhibiting endoplasmic reticulum stress-induced apoptosis

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