Cell receptor studies on seven cases of diffuse histiocytic malignant lymphoma (reticulum cell sarcoma).

Surface phenotyping, histology and the nature of non-Hodgkin lymphoma in 157 patients

“…Both classifications have strong and weak points: the Rappaport is simple to understand, and easy to apply. The major defect in the scheme lies in the mistaken concept of lymphocyte "differentiation" and in the division between histiocytic lymphomas (which are mainly lymphocytic) and lymphocytic lymphomas (Habeshaw et al, 1977). The Kiel classification avoids these drawbacks, but is of a higher order of complexity and is largely unproven "in the field" of clinical applicability.…”

Correlation of surface receptors with histological appearance in 29 cases of non-Hodgkin lymphoma

“…The second is to assess the maturity of the B cell by a number of cell surface markers, and the third is to relate the surface markers to the histology of the tumour. Previous attempts to identify the cells present in human lymphomas by surface marker techniques (Brouet, Labaume and Seligmann, 1975;Cooper et al, 1975;Dorfman, 1975;Gajl-Peezalska, Bloomfield and Sosin, 1975;Habeshaw and Stuart, 1975;Jaffe et al, 1975;Huang et al, 1974;Peter, Mackenzie and Glassy, 1974;Stuart and Habeshaw, 1976;Smith et al, 1973) have all shown that most non-Hodgkin lymphomas consist predominantly of B cells, with a minority of T cells. A few are derived from T cells, and those arising from macrophages are distinctly uncommon.…”

“…Some authors have encountered tumours in which the sum of B and T cells appears to exceed the total cell count. This suggests simultaneous expression by cells of both B and T characteristics, named by us as " receptor overlap " (Lin and Hsu, 1976;Habeshaw and Stuart, 1975;Murphy, 1975).…”

Walter Hubert Lecture, delivered 1 April 1980 to the 21st AGM of the BACR Malignant lymphomas as tumours of the immune system

“…Considerable effort has been directed to studying their immunological and cytochemical markers, which in published reports are also diverse (Peter & MacKenzie, 1974;Aisenberg & Long, 1975;Habeshaw & Stuart, 1975;Leech et al, 1975;Morris & Davey, 1975;Bloomfield et al, 1976;Brouet et al, 1976;Davey et al, 1976;Bloomfield et al, 1977;Lawrence et al, 1978;Lukes et al, 1978a, b;Mann et al, 1979;Pinkus et al, 1979;Suchi et al, 1979;Woda & Knowles, 1979 (Fialkow et al, 1973;Mann et al, 1976). These findings are not surprising since IgM is the immunoglobulin most frequently identified on B lymphocytes from normal peripheral blood (Aisenberg, 1973).…”