Cell-selective encapsulation in hydrogel sheaths via biospecific identification and biochemical cross-linking

Sakai, Shinji; Liu, Yang; Sengoku, Mikako; Taya, Masahito

doi:10.1016/j.biomaterials.2015.02.119

Cited by 28 publications

(20 citation statements)

References 26 publications

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“…Electrospinning [36,37], cell encapsulation [7,67,89] and 3D printing [45] techniques are further improving the design of tumour-environment biomimetics. Without doubt, the interdisciplinary field on biomaterials, tumour-environment interactions and drug delivery will open new avenues for medical progress.…”

Section: Cafs As a Tool In Cancer Therapymentioning

confidence: 99%

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

et al. 2015

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Cancer-associated fibroblasts (CAFs) are drivers of tumour progression and are considered as a target and a tool in cancer diagnostic and therapeutic applications. An increased abundance of CAFs or CAF signatures are recognized as a bad prognostic marker in several cancer types. Tumour-environment biomimetics strongly improve our understanding of the communication between CAFs, cancer cells and other host cells. Several experimental drugs targeting CAFs are in clinical trials for multiple tumour entities; alternatively, CAFs can be exploited as a tool to characterize the functionality of circulating tumour cells or to capture them as a tool to prevent metastasis. The continuous interaction between tissue engineers, biomaterial experts and cancer researchers creates the possibility to biomimic the tumour-environment and provides new opportunities in cancer diagnostics and management.

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Section: Cafs As a Tool In Cancer Therapymentioning

confidence: 99%

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

et al. 2015

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“…Hydrogel sheaths of alginate–, gelatin–, and PVA–Ph of 1 μm thick were developed by soaking the cells in an aqueous solution containing polymer–Ph(s) and H 2 O 2 for several minutes without a significant decrease in cell viability (Figure ) . Cell‐selective coating by the hydrogel sheath was realized through biospecific identification by using HRP conjugated with the antibody toward the antigen on the cell surface …”

Section: Biofabrication Applicationsmentioning

confidence: 99%

“…[87] Cell-selective coating by the hydrogel sheath was realized through biospecific identification by using HRP conjugated with the antibody towardt he antigen on the cell surface. [88]…”

Section: Single-cell Coating With Ah Ydrogel Sheathmentioning

confidence: 99%

Horseradish Peroxidase Catalyzed Hydrogelation for Biomedical, Biopharmaceutical, and Biofabrication Applications

Sakai

Nakahata

2017

Chemistry An Asian Journal

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Horseradish peroxidase (HRP)-catalyzed hydrogelation has attracted much attention owing to the ease of handling, high biocompatibility, and processability. This review summarizes recent developments, including cutting-edge research into the use of HRP-mediated hydrogelation toward biomedical, biopharmaceutical, and biofabrication applications. From the viewpoint of polymer chemistry, the basic chemistry behind hydrogelation, the structure-property relationship, and hybridization of multiple materials by using HRP-catalyzed hydrogelation are summarized. From the chemical engineering perspective, strategies for controlling hydrogelation kinetics, hydrogel characteristics, and hydrogelation processes are summarized and discussed in detail. Strategies for obtaining biomaterials for medical and pharmaceutical use, and biofabrication for tissue engineering and regenerative medicine emerge by unifying the aspects of HRP-mediated hydrogelation.

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“…Hydrogels have been applied in biological, pharmaceutical, and daily-care applications, such as immunoassay, vehicles for drug delivery, eye contact lenses, implantable artificial muscles, and wound dressings, etc. [ 2 3 4 5 6 7 8 9 10 11 12 ]. However, hydrogels made of single polymers usually display poor mechanical behaviors [ 13 ], as we know, single polyvinylalcohol (PVA) hydrogels are hard to meet the requirements of some applications needing high mechanical strengths.…”

Section: Introductionmentioning

confidence: 99%

High performances of dual network PVA hydrogel modified by PVP using borax as the structure-forming accelerator

Huang

Hou

et al. 2017

Designed Monomers and Polymers

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A dual network hydrogel made up of polyvinylalcohol (PVA) crosslinked by borax and polyvinylpyrrolidone (PVP) was prepared by means of freezing-thawing circles. Here PVP was incorporated by linking with PVA to form a network structure, while the introduction of borax played the role of crosslinking PVA chains to accelerate the formation of a dual network structure in PVA/PVP composite hydrogel, thus endowing the hydrogel with high mechanical properties. The effects of both PVP and borax on the hydrogels were evaluated by comparing the two systems of PVA/PVP/borax and PVA/borax hydrogels. In the former system, adding 4.0% PVP not only increased the water content and the storage modulus but also enhanced the mechanical strength of the final hydrogel. But an overdose of PVP just as more than 4.0% tended to undermine the structure of hydrogels, and thus deteriorated hydrogels’ properties because of the weakened secondary interaction between PVP and PVA. Likewise, increasing borax could promote the gel crosslinking degree, thus making gels show a decrease in water content and swelling ratio, meanwhile shrinking the pores inside the hydrogels and finally enhancing the mechanical strength of hydrogels prominently. The developed hydrogel with high performances holds great potential for applications in biomedical and industrial fields.

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Cell-selective encapsulation in hydrogel sheaths via biospecific identification and biochemical cross-linking

Cited by 28 publications

References 26 publications

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics

Horseradish Peroxidase Catalyzed Hydrogelation for Biomedical, Biopharmaceutical, and Biofabrication Applications

High performances of dual network PVA hydrogel modified by PVP using borax as the structure-forming accelerator

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