Cell Senescence as Observed by Electron Microscopic Radioautography

Cell Aging of Mouse Gastrointestinal Tract Observed by Light and Electron Microscopic Radioautography

“…The gastrointestinal tract can be divided into several portions, the oral cavity, the pharynx, the esophagus, the stomach, the small and large intestines and the anus, while the digestive glands consist of both the large glands such as the salivary glands, the liver and the pancreas and the small glands affiliated to the digestive tracts in the gastrointestinal walls such as the gastric glands, intestinal glands of Lieberkuehn or duodenal glands of Brunner. We have published many papers from our laboratory dealing with the macromolecular synthesis of respective digestive organs from the oral cavity to the gastrointestinal tracts and the digestive glands [10, 20, 22, 29-41]. The outline of the results concerning to the synthetic DNA in the digestive organs should be here described in the order of systematic anatomy and special histology as follows.…”

“…1A, 1B). As for the DNA syntheses in these cells, please refer to the original papers which were published already [21, 22, 31, 33, 34]. …”

“…To the contrary, the newly synthesized glucides but not all the glucides in the cells and tissues, can be detected as macromolecular synthesis together with other macromolecules such as DNA, RNA or proteins in various organs of experimental animals by either morphological or biochemical procedures employing RI-labeled precursors. We have studied the sites of macromolecular synthesis in almost all the organs of mice during their aging from prenatal to postnatal development to senescence by means of microscopic RAG [10, 20-22, 31, 62, 63]. The results obtained from glucides synthesis are described according to the order of organ systems in anatomy or histology.…”