2013
DOI: 10.1007/978-3-642-38815-6_10
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Cell-Specific Aptamers for Nano-medical Applications

Abstract: This chapter describes cell-type specific aptamers and their use in diagnostics and therapy. Aptamers are single-stranded oligo(deoxy)nucleotides that selectively bind to their target molecules with high affinity. Cell-type specific aptamers in particular can be identified via SELEX using isolated surface proteins or whole cells as targets.Cell-type specific aptamers have been mostly selected targeting cancer cells, which essentially take into account that about 20 % of the deaths worldwide are due to cancer a… Show more

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