Cell-specific regulation of cytosolic aspartate aminotransferase by glucocorticoids in the rat kidney

Feilleux-Duche, S.; Garlatti, Michèle; Aggerbeck, Μartine; Poyard, Madeleine; Bouguet, J; Hanoune, Jacques; Barouki, Robert

doi:10.1152/ajpcell.1993.265.5.c1298

Cited by 19 publications

(10 citation statements)

References 11 publications

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“…Thus, the induction of ASS and ASL mRNA levels by glucocorticoids appeared tissue-specific and this suggests that the terminal differentiation of the liver and kidney involved different factor(s) of regulation. The lack of induction in the kidney did not seem to reflect a general lack of glucocorticoids response in this organ since some other renal enzymes were shown to be induced by these hormones [30,31]. Interestingly, newborn mice lacking the glucocorticoid receptor gene (by homologous recombination) had an impaired capacity for hepatic enzyme induction and died rapidly, suggesting the absolute necessity of glucocorticoids action during embryogenesis [32].…”

Section: Discussionmentioning

confidence: 98%

Expression of the Genes of Arginine-Synthesizing Enzymes in the Rat Kidney during Development

Goutal¹,

Fairand²,

Husson³

1999

Neonatology

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The expression of two genes, coding for argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL), enzymes which synthesize arginine, was studied by Northern analysis in various tissues of fetal rats. The highest expression of both genes was seen in the small intestine, liver and kidney of the fetus. The developmental expression was observed in the kidney where both mRNA levels remained low during the fetal period and they increased concomitantly in both kidney and liver throughout the perinatal life, suggesting that the aptitude to synthesize arginine appeared and developed within the same period in both organs. This developmental activation of the ASS and ASL genes expression corresponded, at least in part, to a transcriptional mechanism in both tissues, as measured by run-on assay. Bilateral adrenalectomy showed that glucocorticoids did not appear to control the developmental expression of both genes in the kidney, in contrast to the situation observed in the liver.

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Section: Discussionmentioning

confidence: 98%

Expression of the Genes of Arginine-Synthesizing Enzymes in the Rat Kidney during Development

Goutal¹,

Fairand²,

Husson³

1999

Neonatology

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“…Increased levels of AST in serum or plasma usually denote hepatic injury; however, this enzyme is not only specific to the liver and is also found in other organs such as kidney and smooth muscle. Although in many cases of human ischemic ARF, serum AST levels do not rise, levels of this enzyme are elevated after renal tubular injury in the rat (31). As AST is present within the PT (32) and is regarded as a nonspecific marker of extensive cellular disruption or necrosis (33), we have used serum AST in this study as a marker of reperfusion-injury.…”

Section: Discussionmentioning

confidence: 99%

High Density Lipoprotein (HDL) Reduces Renal Ischemia/Reperfusion Injury

Thiemermann¹,

Patel²,

Kvale³

et al. 2003

Journal of the American Society of Nephrology

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Abstract. High-density lipoproteins (HDL) have been shown to reduce organ injury and mortality in animal models of shock via modulation of the expression of adhesion molecules and pro-inflammatory enzymes. As renal inflammation plays an important role in the development of ischemia/reperfusion (I/R) injury of the kidney, the aim of this study was to investigate the ability of HDL to alleviate renal dysfunction and injury in a rat model of renal I/R. HDL (80 mg/kg, intravenous) was administered to male Wistar rats 30 min before bilateral renal ischemia for 45 min followed by reperfusion for up to 48 h. After 6-h reperfusion, HDL significantly reduced (1) renal and tubular dysfunction, (2) tubular and reperfusioninjury, and (3) histologic evidence of renal injury. HDL also improved renal function (after 24-h and 48-h reperfusion) and reduced histologic signs of renal injury (after 48-h reperfusion). Administration of HDL significantly reduced the numbers of polymorphonuclear leukocytes (PMN) infiltrating into renal tissues during reperfusion, which was reflected by an attenuation of the increase in renal myeloperoxidase activity caused by I/R. Furthermore, HDL markedly reduced expression of the adhesion molecules, intercellular adhesion molecule-1 (ICAM-1), and P-selectin during reperfusion. The increase in renal malondialdehyde levels caused by renal I/R was also significantly reduced by HDL, suggesting attenuation of lipid peroxidation subsequent to oxidative stress. These results demonstrate that HDL significantly reduces renal I/R injury and severity of ischemic acute renal failure. It is proposed that the mechanism of protection involves reduction of the expression of adhesion molecules, resulting in reduction of PMN infiltration and oxidative stress.

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“…The SGPT and SGOT are not only specific to the liver but also found in other organs such as kidney and smooth muscle. These enzymes are especially elevated after renal tubular injury in rat 37 . Because SGPT and SGOT are present within the proximal tubules and are regarded as a nonspecific marker of extensive cellular damage 38 , we have used serum SGPT and SGOT in this study as markers of reperfusion injury.…”

Section: Discussionmentioning

confidence: 90%

Role of Ocimum Canum in Prevention of Reperfusion-Induced Renal Ischemia in Wistar Albino Rats

Behera

Babu²,

Ramani

et al. 2012

Int J of Biomed & Adv Res

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Acute renal failure is defined as rapid loss of renal function and has been associated with a high mortality rate. Ischemia and reperfusion (I/R) injury of the kidney is the most prominent cause of intrinsic acute renal failure. Activation of reactive oxygen species is implicated in renal ischemia/reperfusion (I/R) injury. This study investigated the anti-ischemic effect of hydro-alcoholic leaf extract of Ocimum canum (OC) against renal I/R injury by its effect on reactive oxygen species. Wistar albino rats were administered different doses of hydro-alcoholic leaf extract of Ocimum canum (OC) before renal ischemia, followed by reperfusion for 24 hours. Serum creatinine, Serum cystatin C, serum oxaloacetate transaminase (SGOT), serum pyruvate transaminase (SGPT), blood urea nitrogen (BUN) and Lactate dehydrogenase (LDH) were measured for renal dysfunction. Serum and tissue malondialdehyde (MDA), reduced glutathione (GSH) levels, catalase (CAT), and superoxide dismutase (SOD) levels were measured. Renal sections were analyzed for histological grading of renal injury. Hydro-alcoholic leaf extract of Ocimum canum (OC) significantly reduced increased creatinine, cystatin C, serum oxaloacetate transaminase (SGOT), serum pyruvate transaminase (SGPT), blood urea nitrogen (BUN) and lactate dehydrogenase (LDH). Ocimum canum also increased kidney superoxide dismutase activity, catalase and reduced glutathione levels and reduced the malondialdehyde levels. Hydro-alcoholic leaf extract of Ocimum canum reduced histological renal damage. These results suggest that the hydro-alcoholic leaf extract of Ocimum canum reduces renal dysfunction and injury caused by renal I/R.

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Cell-specific regulation of cytosolic aspartate aminotransferase by glucocorticoids in the rat kidney

Cited by 19 publications

References 11 publications

Expression of the Genes of Arginine-Synthesizing Enzymes in the Rat Kidney during Development

Expression of the Genes of Arginine-Synthesizing Enzymes in the Rat Kidney during Development

High Density Lipoprotein (HDL) Reduces Renal Ischemia/Reperfusion Injury

Role of Ocimum Canum in Prevention of Reperfusion-Induced Renal Ischemia in Wistar Albino Rats

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