Cell surface and relative mRNA expression of heat shock protein 70 in human synovial cells

Sedláčková, Lucie; Nguyen, Thị Thu Hien; Zlacka, Denisa; Sosna, A; Hromadníková, Ilona

doi:10.1080/08916930802227466

Cited by 24 publications

(11 citation statements)

References 19 publications

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“…Health factors possibly associated with HSP70 were assessed via face-to-face interview and data abstraction from medical chart reviews. Health factors assessed included length of time since abnormal endometrial biopsy was obtained; body mass index (BMI) (Ghayour-Mobarhan et al, 2007); tumor cellular classification, grade, and stage (Nanbu et al, 1998); and comorbid connective tissue disease (Sedlackova et al, 2009). Medical comorbidity severity was assessed using the Charlson Comorbidity Index (Charlson et al, 1987).…”

Section: Methodsmentioning

confidence: 99%

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer

Pereira

Sannes

Dodd

et al. 2010

Brain, Behavior, and Immunity

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Heat shock protein 70 (HSP70), an intracellular chaperone "stress protein," has been identified in the extracellular milieu, where it may exert regulatory effects upon monocytes. HSPs are overexpressed in many cancers and implicated in tumorigenesis. Few studies have examined the relationship between psychosocial factors and HSP levels, particularly in cancer. The purpose of the present study was to examine the relationship between negative psychosocial states (life events stress and negative mood states) and serum concentration of HSP70 antibodies among women with endometrial cancer, the fourth most common cancer among women in the United States. Thirty-six women scheduled to undergo surgery for suspected endometrial adenocarcinoma underwent a psychosocial assessment and peripheral venous blood draw. Life events stress was assessed using an abbreviated version of the Life Experiences Survey; negative mood states were assessed using abbreviated versions of the Structured Interview Guide for the Hamilton Anxiety and Depression Scales and the Profile of Mood States. HSP70 antibody levels were regressed sequentially on life events stress and negative mood variables while controlling for body mass index (BMI) and cancer stage. Results revealed that greater HSP70 antibody concentrations were associated with greater impact of recent negative life events (p = .04), anxious symptomatology (p = .007), depressive symptomatology (p = .03), and total mood disturbance (p = .001) after controlling for BMI and cancer stage. While based on a modest sample size, these preliminary results suggest that larger-scale research exploring the relationships among psychosocial factors and HSP70 in cancer patients may be warranted.

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Section: Methodsmentioning

confidence: 99%

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer

Pereira

Sannes

Dodd

et al. 2010

Brain, Behavior, and Immunity

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“…The observation of elevated levels of hsp70 in synovial fluids from inflamed joints of RA patients is one of these factors. Hsp70 is found both within the fibroblasts at the joint and in the fluid itself [99, 100]. The significant increase in extracellular hsp70 in arthritic joints is profoundly correlative because nonarthritic joints in the same individual patients have no elevation in hsp70.…”

Section: Extracellular Hsps and The Etiology Of Autoimmunitymentioning

confidence: 99%

CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity

Binder

Zhou

Messmer

et al. 2012

Autoimmune Diseases

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Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setting of cancer and infectious disease. These immune responses have primarily been harnessed for the immunotherapy of cancer in the clinical setting. However, because of the ability of HSPs to prime diverse immune responses, they have also been used for modulation of immune responses during autoimmunity. The apparent dichotomy of immune responses elicited by HSPs is discussed here on a molecular and cellular level. The potential clinical application of HSP-mediated immune responses for therapy of autoimmune diseases is reviewed.

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“…Furthermore, in patients with RA or JIA, augmented Hsp expression has been observed in the inflamed synovium and found to be important for proper functioning of Hsp-specific regulatory T cells (3). Our group previously reported higher expression of Hsp70 in synovial cells derived from patients with severe RA and JIA (4).…”

mentioning

confidence: 93%

Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls

Sedláčková

Sosna

Vavrincová

et al. 2011

Scandinavian Journal of Rheumatology

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Cell surface and relative mRNA expression of heat shock protein 70 in human synovial cells

Cited by 24 publications

References 19 publications

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer

CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity

Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls

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