Cell Surface Glycoproteins in Embryonic Development

Bourrillon, R; Auger, Michèle

doi:10.1016/s0074-7696(08)60642-7

Cited by 35 publications

(14 citation statements)

References 385 publications

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“…Cell surface carbohydrates play critical roles in gamete development (76) as well as sperm-egg interactions (77)(78)(79) and blockage of polyspermy (80 -82). Cell surface "stage-specific carbohydrate antigens" have historically been used as markers during embryogenesis (14,(83)(84)(85)(86)(87)(88)(89)(90), where they correlate with cellular interactions during developmental transitions in pre-and postimplantation embryos (8,75,91,92). Glycans also influence numerous cellular functions, such as modulating cell signals and regulating the balance between cell adhesion versus migration during embryogenesis (8,93,94).…”

Section: Discussionmentioning

confidence: 99%

Regulation of Glycan Structures in Murine Embryonic Stem Cells

Nairn

Aoki

Rosa

et al. 2012

Journal of Biological Chemistry

100

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Background: Glycans contribute to vertebrate development, but regulatory mechanisms are unknown. Results: Glycans and transcripts encoding the glycosylation machinery were profiled during stem cell differentiation. Conclusion: Changes in glycans frequently correlated with changes in transcripts, supporting a significant role for transcriptional regulation. Significance: Knowledge of the mechanisms that regulate glycan expression provides insight into the roles of glycosylation in development.

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Section: Discussionmentioning

confidence: 99%

Regulation of Glycan Structures in Murine Embryonic Stem Cells

Nairn

Aoki

Rosa

et al. 2012

Journal of Biological Chemistry

100

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“…Carbohydrate molecules play an important role in the complex cell recognition and cell sorting processes of the developing brain as well as in the maintenance of specific control functions of the mature CNS (reviewed by Mann 1988;Schwarting and Yamamoto 1988;Bourrillon and Aubery 1989).…”

Section: Discussionmentioning

confidence: 99%

“…The transient expression of CD15 during developmental processes, as demonstrated in the present study, suggests that the epitope could be somehow masked during "silent" periods when CD15 immunoreactivity is absent. Changes in the sugar moiety could implicate either the addition or cleavage of specific carbohydrates, as is known to occur during "maturation" of antigenic determinants of the blood group system and stage-specifically regulated antigens in various differentiating tissues (reviewed by Feizi 1985;Hakomori 1986;Mann 1988;Schwarting and Yamamoto 1988;Bourrillon and Aubery 1989).…”

Section: Discussionmentioning

confidence: 99%

The carbohydrate epitope 3-fucosyl-N-acetyllactosamine is developmentally regulated in the human cerebellum

1992

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The carbohydrate epitope 3-fucosyl-N-acetyl-lactosamine (CD15) is involved, as a constituent of glycoconjugates, in cell-cell interactions and cell sorting during rodent CNS morphogenesis. The present study was designed to test whether CD15 is also involved in the development of the human CNS. Human cerebellar hemispheres and vermes from the 24th week of gestation (wg) to the 26th postnatal month (pnm) and from adults were investigated for CD15 immunoreactivity, using the monoclonal antibody MMA. Our findings establish that the carbohydrate moiety is developmentally regulated in neuronal and glial cells during their differentiation. First, the parallel fibers of granule cells are CD15+ during the epoch of synaptogenesis with Purkinje cell dendrites. Second, a subpopulation of neurons from the dentate nucleus is transiently CD15+ from the 32nd wg until the 15th pnm. Third, at the onset of myelination (around the 35th wg), CD15 immunoreactivity is discernible in the cytoplasm of young oligodendrocytes. Immunoreactivity on protoplasmic astrocytes of the inner granular layer and on fibrous astrocytes of the white matter progressively increases during fetal development. In addition, the CD15 epitope is persistently present on Bergmann glial processes and ependymal cells. Within the three subdivisions of the cerebellum, i.e., hemispheres, vermis, and flocculonodular lobe, the CD15 expression follows a different timing of morphogenesis. For example, diminution of immunoreactivity in the parallel fibers occurs first in the phylogenetically older flocculonodular lobe and vermis, and later in the phylogenetically younger hemispheres. This study shows that in the human cerebellum the distribution of CD15 undergoes marked developmental changes. This epitope may also act in cell-to-cell recognition, and perhaps could play a role in controlling CNS development.

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“…There is a considerable body of evidence that adhesive interactions between homologous cells in the developing embryo, and between the embryonic cell surface and extracellular matrix, are important in cellular recognition, rearrangements, migration and differentiation (reviewed by Edelman 1983;Bourrillon and Aubrey 1989;Sanders 1989). Cell-cell recognition, often leading to the formation of selective contacts and enabling the cells to associate selectively into tissues, depends largely on the expression of specific macromolecules associated with the cell surface (Edelman 1983).…”

Section: Introductionmentioning

confidence: 99%

N-CAM, polysialic acid and chick tail bud development

Griffith

Wiley

1991

Anat Embryol

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We have previously shown that the binding of the lectin wheat germ agglutinin (WGA) to developing tail buds results in a range of caudal axial defects, which were most likely due to the affinity of the lectin for sialic acid residues. In the present study, we examined the distribution and role of a sialic acid-containing glycoprotein, N-CAM, in chick tail bud development. In the early tail bud, anti N-CAM, staining was found in the medullary cord. However, there was no uptake of an antibody specific to N-CAM containing moderate to long chains of polysialic acid (5A5 monoclonal antibody). At later stages, while N-CAM localized throughout the neural tube, staining with the 5A5 antibody was restricted to the floor plate. Sub-blastodermal injection of the anti N-CAM antibody beneath the tail bud region of HH stages 13-14 embryos produced caudal axial malformations. These malformations included the presence of accessory segments of neural tube and/or notochord, and fusion between the neural tube and underlying segment of notochord. Our results suggest that N-CAM is present during the development of the secondary neuraxis from the tail bud, although the highly sialylated form of this molecule could not be visualized until relatively late stages. N-CAM probably plays a role in the normal course of tail bud development, since perturbation of the molecule with an antibody resulted in malformations. Since these malformations were similar to those we have previously reported when we treated similarly staged chick embryos with WGA, there is a possibility that the sialic acid residues recognized and bound by the lectin are those associated with the N-CAM molecule.

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Cell Surface Glycoproteins in Embryonic Development

Cited by 35 publications

References 385 publications

Regulation of Glycan Structures in Murine Embryonic Stem Cells

Regulation of Glycan Structures in Murine Embryonic Stem Cells

The carbohydrate epitope 3-fucosyl-N-acetyllactosamine is developmentally regulated in the human cerebellum

N-CAM, polysialic acid and chick tail bud development

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