Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions

Larijani, Bagher; Heravani, Najmeh Foroughi; Alavi-Moghadam, Sepideh; Goodarzi, Parisa; Rezaei‐Tavirani, Mostafa; Payab, Moloud; Gholami, Mahdi; Razi, Farideh; Arjmand, Babak

doi:10.1007/5584_2020_491

Cited by 10 publications

(6 citation statements)

References 85 publications

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“…Studies show an improvement among these children when they undergo cellular therapy [12][13][14] . While it cannot be considered a curative treatment, it can be considered a possibility to improve the poor quality of life of these patients may be living.…”

Section: Discussionmentioning

confidence: 99%

“…Even though these procedures are implemented for different reasons and with different objectives, non-verbal-patients have the same risk of experiencing pain. In this context, the use of regenerative medicine with stem cell therapy for different pathologies [4][5][6][7] , among these, infantile cerebral palsy (ICP) 8,9 and autism spectrum disorder (ASD) 10,11 is presented as an innovative therapy with promising results [12][13][14] . One of the sources for obtaining stem cells may be the bone marrow (BM), and the route of administration may be intrathecal.…”

Section: Introductionmentioning

confidence: 99%

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Pain assessment of non-verbal patients undergoing bone marrow aspirations and lumbar puncture: Preliminary results

Mancı́as-Guerra¹,

Sánchez-García²,

Velasco-Ruiz³

et al. 2021

RMU

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Introduction: Pain assessment in non-verbal patients during medical interventions can be challenging due to communication problems. Therefore, it is necessary to use new pain measurement tools for these patients. Objective: The objective of the study was to assess the incidence of pain in patients with cerebral palsy (CP) and autism spectrum disorder (ASD) who undergo bone marrow aspiration (BMA) and lumbar puncture (LP) for cell therapy. Methods: The "Non-Communicating Children's Pain Checklist-Revised" checklist was used to observe the behavior of 15 patients diagnosed with CP and ASD before and after cell therapy. The evaluation was carried out simultaneously by a caregiver and by the staff of the medical team on three occasions. Scores ≥ 7 were considered as the presence of moderate or severe pain. Results: Regarding the scores obtained in the second survey (30 min after the BMA and LP), the caregivers reported values of < 7 points in 10 patients (66.7%). At the same time, in the evaluation performed by caregivers 24 h after the procedure, scores of < 7 points were reported in eight (53.3%). The items with the highest scores in the surveys were verbal and facial expressions, social attitudes, and activities. Conclusions: The procedures carried out in cell therapy were safe and well-tolerated by this group of patients, with an incidence of pain in only 33.3%, which can be considered a therapeutic alternative to improve their current condition without compromising their integrity or quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pain assessment of non-verbal patients undergoing bone marrow aspirations and lumbar puncture: Preliminary results

Mancı́as-Guerra¹,

Sánchez-García²,

Velasco-Ruiz³

et al. 2021

RMU

View full text Add to dashboard Cite

show abstract

“…Over recent years, investigations were indicated regenerative medicine can be paved the road for the treatment of many life-threatening diseases. In other words, translational cell biology can be considered as an innovative and efficient healthcare intervention for the promotion of the quality of life and medical costs reduction (Goodarzi et al 2014(Goodarzi et al , 2015Payab et al 2018, Baradaran-Rafii et al 2020Larijani et al 2020). Herein, the great discoveries have highlighted that MSCs as regenerative medicine soldiers have long been regarding, based on their multi-potential differentiation capacity and self-renewal ability along with immunomodulatory potency.…”

Section: Importance Of Cell Therapy and Regenerative Medicinementioning

confidence: 99%

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

et al. 2020

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Acute respiratory infections as one of the most common problems of healthcare systems also can be considered as an important reason for worldwide morbidity and mortality from infectious diseases. Coronaviruses are a group of well-known respiratory viruses that can cause acute respiratory infections. At the current state, the 2019 novel coronavirus is cited as the most worldwide problematic agent for the respiratory system. According to investigations, people with old age and underlying diseases are at higher risk of 2019 novel coronavirus infection. Indeed, they may show a severe form of the disease (with severe acute respiratory infections). Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by the 2019 novel

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“…Hereupon, the evaluation of more efficient approaches is demanded. Given the astonishing outcomes of cell-based therapies for different diseases (Goodarzi et al 2018b ; Rahim and Arjmand 2017 ; Baradaran-Rafii et al 2020 ; Larijani et al 2020 ; Arjmand et al 2019 ), it isn’t unlikely that cell therapies (specifically using MSCs) will also be effective for individuals with scleroderma. Indeed, MSCs as a practicing member of regenerative medicine with angiogenic, anti-fibrotic, anti-inflammatory, and immunomodulatory functions, can affect the various disordering processes of the disease mainly via secreting specific efficient bioactive molecules (Han et al 2019 ).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives

et al. 2020

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Systemic sclerosis is a rare chronic autoimmune disease with extensive microvascular injury, damage of endothelial cells, activation of immune responses, and progression of tissue fibrosis in the skin and various internal organs. According to epidemiological data, women’s populations are more susceptible to systemic sclerosis than men. Until now, various therapeutic options are employed to manage the symptoms of the disease. Since stem cell-based treatments have developed as a novel approach to rescue from several autoimmune diseases, it seems that stem cells, especially mesenchymal stem cells as a powerful regenerative tool can also be advantageous for systemic sclerosis treatment via their remarkable properties including immunomodulatory and anti-fibrotic effects. Accordingly, we discuss the contemporary status and future perspectives of mesenchymal stem cell transplantation for systemic sclerosis.

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Cell Therapy Targets for Autism Spectrum Disorders: Hopes, Challenges and Future Directions

Cited by 10 publications

References 85 publications

Pain assessment of non-verbal patients undergoing bone marrow aspirations and lumbar puncture: Preliminary results

Pain assessment of non-verbal patients undergoing bone marrow aspirations and lumbar puncture: Preliminary results

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

Mesenchymal stem cell as a novel approach to systemic sclerosis; current status and future perspectives

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