Cell therapy with autologous mesenchymal stem cells—how the disease process impacts clinical considerations

Wang, Jin; Liao, Lianming; Wang, Shuiliang; Tan, Ming Jen

doi:10.1016/j.jcyt.2013.01.218

Cited by 49 publications

(38 citation statements)

References 96 publications

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“…Even when derived from the same tissue of origin, MSCs demonstrate tremendous donor-to-donor variability. Intuitively, donor health may influence the availability and functional potential of MSCs (Kuznetsov et al, 2009;Wang et al, 2013). Similarly, as donors age, MSC availability, self-renewal capacity D'Ippolito et al, 1999;Katsara et al, 2011;Stenderup et al, 2003).…”

Section: Mscs Exhibit Heterogeneity On Multiple Levelsmentioning

confidence: 99%

On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

McLeod¹,

Mauck

2017

eCM

157

137

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Mesenchymal stem cells (MSCs) display substantial cell-to-cell variation. This heterogeneity manifests among donors, among tissue sources, and within cell populations. Such pervasive variability complicates the use of MSCs in regenerative applications and may limit their therapeutic efficacy. Most conventional assays measure MSC properties in bulk and, as a consequence, mask this cell-to-cell variation. Recent studies have identified extensive variability amongst and within clonal MSC populations, in dimensions including functional differentiation capacity, molecular state (e.g. epigenetic, transcriptomic, and proteomic status), and biophysical properties. While the origins of these variations remain to be elucidated, potential mechanisms include in vivo micro-anatomical heterogeneity, epigenetic bistability, and transcriptional fluctuations. Emerging tools for single cell analysis of MSC gene and protein expression may yield further insight into the mechanisms and implications of single cell variation amongst these cells, and ultimately improve the clinical utility of MSCs in tissue engineering and regenerative medicine applications. This review outlines the dimensions across which MSC heterogeneity is present, defines some of the known mechanisms that govern this heterogeneity, and highlights emerging technologies that may further refine our understanding and improve our clinical application of this unique cell type.

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Section: Mscs Exhibit Heterogeneity On Multiple Levelsmentioning

confidence: 99%

On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

McLeod¹,

Mauck

2017

eCM

157

137

View full text Add to dashboard Cite

show abstract

“…Under suitable conditions, BM-MSCs can differentiate into ectoderm-derived tissue [36]. Cell therapy with BM-MSCs holds enormous promise for the treatment of a large number of diseases [37]. In the field of sweat gland regeneration, BM-MSCs are the most studied and widely used stem cells.…”

Section: Bm-mscsmentioning

confidence: 99%

Mesenchymal stem cells for sweat gland regeneration after burns: From possibility to reality

Tan

Zhang

et al. 2016

Burns

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“…Stem cells have recently received increased attention owing to their potential for use in tissue engineering and clinical applications [12,13]. Stem cells are defined as self-renewable, multipotent progenitor cells with the capacity to differentiate into several distinct lineages [14].…”

Section: Introductionmentioning

confidence: 99%

Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy

et al. 2015

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Cell therapy with autologous mesenchymal stem cells—how the disease process impacts clinical considerations

Cited by 49 publications

References 96 publications

On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

On the origin and impact of mesenchymal stem cell heterogeneity: new insights and emerging tools for single cell analysis

Mesenchymal stem cells for sweat gland regeneration after burns: From possibility to reality

Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy

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