Cell therapy with bone marrow stromal cells after intracerebral hemorrhage: impact of platelet-rich plasma scaffolds

Vaquero, Jesús; Otero, Laura; Bonilla, Celia; Aguayo, Concepción; Rico, Miguel A.; Rodríguez, Alicia; Zurita, Mercedes

doi:10.1016/j.jcyt.2012.10.005

Cited by 42 publications

(41 citation statements)

References 38 publications

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“…Many stem cell administration routes have been tested, but it remains unclear which is the best option. Findings in ICH model support that cervical vein delivery is inefficient [133] , whereas good outcomes were already observed following stem cell delivery in brain parenchyma [66,111,[113][114][115][116]121,126,[134][135][136][137] , lateral ventricle [120,133] , tail vein [117,119,122,[124][125][126]138,139] , and carotid artery [133,140,141] . However, each one of these alternatives has drawbacks.…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 68%

“…In late transplantation studies, intracerebral stem cell implantation was performed only two months after ictus. Even so, good functional and morphological outcomes could be observed [111,136] . It is also important to keep in mind that ICH dynamics in rats and humans, as previously discussed, are clearly different in many aspects, including temporality.…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

“…However, apart from this studies, the most common quantity injected in the tail vein is of 3 million cells, suspended in 1 or 2 mL of saline solution [117,119,124,125] . The amount of intracerebrally grafted cells varied up to 25 fold among studies [66,113,115,121,136] . Interestingly, in general, the vehicle volume is not necessarily proportional with the number of cells in suspension ( Table 1).…”

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

“…; 1 × 10 6 1000; 2000 TV Vaquero et al [136] Col Ⅳ hBMSC [119] Col Ⅶ BMSC 1 h 1 × 10 6 1000 TV Wang et al [137] Col Ⅶ NSC 72 h 1 × 10 6 500 (TV); 2 (BP) TV; BP Yang et al [121] Col Ⅰ BMSC (overexpressing GDNF) 72 h 5 × 10 5 20 BP Yang et al [117] ABI hUCSC 24 h; 72 h; 7 d 3 × 10 6 2000 TV Yang et al [159] Col Ⅶ hASC 24 h 1 × 10 6 200 FV Zhang et al [133] Col Ⅶ …”

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confidence: 99%

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Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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Intracerebral hemorrhage (ICH) is a very complex pathology, with many different not fully elucidated etiologies and prognostics. It is the most severe subtype of stroke, with high mortality and morbidity rates. Unfortunately, despite the numerous promising preclinical assays including neuroprotective, anti-hypertensive, and anti-inflammatory drugs, to this moment only symptomatic treatments are available, motivating the search for new alternatives. In this context, stem cell therapy emerged as a promising tool. However, more than a decade has passed, and there is still much to be learned not only about stem cells, but also about ICH itself, and how these two pieces come together. To date, rats have been the most widely used animal model in this research field, and there is much more to be learned from and about them. In this review, we first summarize ICH epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts. Core tip: In this review, we first summarize intracerebral hemorrhage (ICH) epidemiology, risk factors, and pathophysiology. We then present different methods utilized to induce ICH in rats, and examine how accurately they represent the human disease. Next, we discuss the different types of stem cells used in previous ICH studies, also taking into account the tested transplantation sites. Finally, we summarize what has been achieved in assays with stem cells in rat models of ICH, and point out some relevant issues where attention must be given in future efforts.Cordeiro MF, Horn AP. Stem cell therapy in intracerebral hemorrhage rat model. World J Stem Cells 2015; 7(3): 618-629

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Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 68%

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

Section: Preclinical Studies: An Heterogeneous Approach For An Heteromentioning

confidence: 99%

mentioning

confidence: 99%

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Stem cell therapy in intracerebral hemorrhage rat model

Cordeiro

Horn

2015

WJSC

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“…The use of PRP as scaffold for the intracerebral administration of bone marrow stem cells resulted in a significant neurologic improvement in experimental animals presenting induced intracerebral hemorrhage. In addition, post-mortem histologic analysis showed that animals that received PRP scaffolds had the stem cells integrated in the injured tissues and presented endogenous neurogenesis, measured by the expression of specific glial proteins and neuronal nucleus [12].…”

Section: Clinical Applications Of Prpmentioning

confidence: 99%

Platelet-rich plasma therapy and reproductive medicine

Bös-Mikich

Oliveira²,

Frantz³

2018

J Assist Reprod Genet

109

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Reports on clinical uses of platelet-rich plasma (PRP) have dramatically increased in the last decade. Indications for PRP therapy range from muscle and skeletal injuries to hair re-growth. More recently evidences have shown its positive effects in promoting endometrial and follicular growth and gestation in assisted reproduction cycles. We discuss the putative role of PRP on endometrial receptivity, with a brief history of its applications in research and clinical therapies. Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated, not based on scientific data. There is an unmet need for advanced research to corroborate present findings in the clinical scenario.

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Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis

Qin

Song

et al. 2015

Neurol Sci

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Stem cell to be a new intervention for treating intracerebral hemorrhage (ICH) might benefit humans. Therefore, we collected animal studies to find the effect of this innovative treatment. In July 2014, we searched Medline (from 1950), Embase (from 1980), China Biology Medicine disk (from 1978) for studies on stem cells used for treating experimental ICH in animal models that reported neurobehavioral and structural outcome. We evaluated the quality of these studies and used a weighted mean difference random affects model for the meta-analysis. We have collected 30 studies from 650 publications identified through systematic review describing the effects of 5 different type of stem cells on 12 different neurobehavioral scales with 1101 rodents or monkeys. Although there is lack of uniformity of the evaluation methods, these researches showed consistent improvements both in neurobehavioral function and structural outcomes. Besides, the quality of these studies needs to be raised. In conclusion, stem cells hold extensive potential in treating ICH, which should be further evaluated with more evidence-based, high-quality animal studies.

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Cell therapy with bone marrow stromal cells after intracerebral hemorrhage: impact of platelet-rich plasma scaffolds

Abstract: PRP-derived scaffolds increase the viability and biologic activity of BMSCs and optimize functional recovery when this type of cell therapy is applied after ICH.

Cited by 42 publications

References 38 publications

Stem cell therapy in intracerebral hemorrhage rat model

Stem cell therapy in intracerebral hemorrhage rat model

Platelet-rich plasma therapy and reproductive medicine

Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis

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