Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension

Exosomal miR‐3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations

“…Intercellular communication through either cell-to-cell contact or paracrine effects is believed to be a key process in vascular remodeling. 34,35 Exosomes, which are newly identified natural aneurysm. 33,[36][37][38][39] Exosomes show excellent prognostic and therapeutic potential for vascular diseases.…”

“…Intercellular communication through either cell‐to‐cell contact or paracrine effects is believed to be a key process in vascular remodeling. 34 , 35 Exosomes, which are newly identified natural nanocarriers and intercellular messengers, play a pivotal role in regulating cell‐to‐cell communication and have emerged as important mediators in the pathogenesis of vascular diseases, including atherosclerosis, neointima formation (and vascular repair), primary hypertension, pulmonary artery hypertension, and aortic aneurysm. 33 , 36 , 37 , 38 , 39 Exosomes show excellent prognostic and therapeutic potential for vascular diseases.…”

Biology and function of pericytes in the vascular microcirculation

“…Wnt5a as a key mediator in the establishment of pulmonary vascular EC-pericyte interactions, and Wnt signaling can inhibit the expressions of coiled-coil like receptor 7 (FZD7) and cell division cycle 42 (CDC42) in lung tissues, which could contribute to PH by reducing the viability of newly formed vessels. 67,68 Finally, VEGF and slit guide ligand 3 (SLIT3) pathways have been shown to play a central role in cell growth and angiogenesis. SLIT3, integrin subunit α8 (ITGA8) and their homologues nephronectin (NPNT) and PDGF-BB were found to be upregulated in pericytes of patients with IPAH, suggesting that they may play an autocrine role in pericyte hypertrophy.…”

“…Thirdly, the Wnt pathway mediates communication between pericytes and other cells. Wnt5a as a key mediator in the establishment of pulmonary vascular EC‐pericyte interactions, and Wnt signaling can inhibit the expressions of coiled‐coil like receptor 7 (FZD7) and cell division cycle 42 (CDC42) in lung tissues, which could contribute to PH by reducing the viability of newly formed vessels 67,68 . Finally, VEGF and slit guide ligand 3 (SLIT3) pathways have been shown to play a central role in cell growth and angiogenesis.…”