Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles

Sato, Hironori; Orensteint, Jan; Dimitrov, Dimiter S.; Martin, Malcolm A.

doi:10.1016/0042-6822(92)90038-q

Cited by 271 publications

(191 citation statements)

References 43 publications

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“…Rapid cell-to-cell spread was observed in early studies of HIV and was compared to processes by which herpesviruses and poxviruses spread (38,49,77). HIV is highly cell associated, and the infectivity of cell-associated virus is much higher than that of cell-free virus (15,19).…”

Section: Hivmentioning

confidence: 99%

Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread

Johnson

Huber

2002

J Virol

231

189

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Section: Hivmentioning

confidence: 99%

Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread

Johnson

Huber

2002

J Virol

231

189

View full text Add to dashboard Cite

“…The movement of viral antigens and genomic RNA between cells followed by the de novo synthesis of viral DNA and protein in the target cell testify to the rapid kinetics and productive nature of this mode of viral spread (35,38) (39). We have recently followed this up and describe the formation of an HIV-1-induced VS between T-cells (21).…”

Section: The Hiv-1 T Cell Vsmentioning

confidence: 99%

“…The rapid kinetics of HIV-1 infection of target T-cells via direct transfer from infected T-cells is well-established (35)(36)(37), although the molecular details of this process had not been elucidated. The movement of viral antigens and genomic RNA between cells followed by the de novo synthesis of viral DNA and protein in the target cell testify to the rapid kinetics and productive nature of this mode of viral spread (35,38) (39).…”

Section: The Hiv-1 T Cell Vsmentioning

confidence: 99%

Retroviral Spread by Induction of Virological Synapses

Jolly

Sattentau

2004

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206

180

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Cells of the immune system communicate via the formation of receptor-containing adhesive junctions termed immunological synapses. Recently, retroviruses have been shown to subvert this process in order to pass directly from infected to uninfected immune cells. Such cell-cell viral dissemination appears to function by triggering existing cellular pathways involved in antigen presentation and T-cell communication. This mode of viral spread has important consequences for both the virus and the host cells in terms of viral pathogenesis and viral resistance to immune and therapeutic intervention. This review summarises the current knowledge concerning virological synapses induced by retroviruses.

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“…Viral transmission through cell-to-cell contact has been reported between infected CD4 ÷ T cells and epithelial cells (Phillips et al, 1992), from both infected monocytic (Valentin et al, 1990) and dendritic (Cameron et aL, 1992) cells to CD4 + T cells, and between CD4 + T cells themselves (Gupta et al, 1989;Sato et aL, 1992).…”

Section: Introductionmentioning

confidence: 99%

Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells

Mercure

Phaneuf²,

Wainberg³

1993

Journal of General Virology

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The presence of unintegrated viral DNA has been reported in cells persistently infected by lentiviruses, including human immunodeficiency virus type 1 (HIV-1). We confirm that CD8 + cells can be productively and persistently infected by HIV-1 for up to 4 months, as determined by secretion of viral core antigen p24 into the extracellular medium and by indirect immunofluorescence. The expression of the external viral glycoprotein gpl20 at the surface of these cells was demonstrated by two-colour flow cytometry. Progeny virions recovered from CD8 ÷ cells were infectious in CD4 ÷ T cells. Despite an absence of significant cytopathology, these chronically infected CD8 ÷ cells were shown to harbour unintegrated HIV-1 DNA, as detected by quantitative PCR. Both linear and circular forms of the extrachromosomal viral genome were present in infected CD8 ÷ cells, as early as 3 weeks before a peak in viral replication. These findings provide evidence that the presence of unintegrated viral DNA during lentiviral infection may not always correlate with c.p.e.

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Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles

Cited by 271 publications

References 43 publications

Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread

Directed Egress of Animal Viruses Promotes Cell-to-Cell Spread

Retroviral Spread by Induction of Virological Synapses

Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells

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