“…In rodents, volitional forelimb movements such as reach-to-grasp (Estebanez et al, 2017;Galiñanes et al, 2018;Guo et al, 2015;Levy et al, 2020;Sauerbrei et al, 2019;Wang et al, 2017) or pulling / pushing a grasped lever (Dacre et al, 2019;Hira et al, 2013;Isomura et al, 2009;Miri et al, 2017;Morandell and Huber, 2017;Park et al, 2019) have been associated with widespread, bidirectional neuronal modulation in both superficial and deep layers of sensorimotor cortex, driven by long-range inputs from motor thalamus (Dacre et al, 2019;Sauerbrei et al, 2019;Tanaka et al, 2018). Both excitatory and inhibitory neurons display dense task-related activity which emerges across learning and correlates with enhanced limb coordination (Hwang et al, 2019;Laubach et al, 2000;Masamizu et al, 2014;Peters et al, 2014).…”